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Biomedical subjects

A Kennedy

Publications and source records attributed to A Kennedy.

At least 217 records · Page 12Linked to original sources
PubMed1977

Small bowel ischaemia and infarction in young women taking oral contraceptives and progestational agents.

Case histories of three young women who suffered small bowel infarction associated with oral contraceptives and progestational agents are presented. Two infarctions were due to superior mesenteric artery thrombosis and one to superior mesenteric vein thrombosis. All of these patients were of blood group A and smokers, factors which are known to predispose to vascular thrombosis. A study was made of 18 additional cases reported in the literature. It was found that many of these cases presented with a history of symptoms of 2 weeks of more and at operation some of the cases appeared to be reversible. One case was reported where apparent reversion of the process of vascular thrombosis occurred after cessation of the oral contraceptive.

Adult↗
PubMed1975

A comparison of different methods of detecting mucin in adenocarcinomas of the lung.

The correct classification of carcinoma of the lung is not only of therapeutic and prognostic importance but is also considered to have epidemiological and aetiological significance. Histological tests for mucin are essential in the classification of lung tumours but there is little information available about the influence of the method of detection used on the results of classification. Five established staining techniques were tested using paraffin blocks from surgical specimens of 81 human lung tumours diagnosed as adenocarcinoma, i.e. tumours of WHO Type III. Mowry's alcian blue-periodic acid-Schiff (AB-PAS) technique gave the highest proportion of positives (93%) slightly fewer (90%) being obtained by the PAS technique alone. Both these methods were influenced by the presence of cytoplasmic hyaline globules, structures which cannot be regarded as mucin. The stain recommended by the World Health Organization was also influenced by the presence of hyaline globules, was less frequently positive than the PAS techniques and was considered to have no special advantages. The aldehyde fuchsin-alcian blue sequence was positive in only 83% of cases but provided some information about the type of mucin present. Southgate's mucicarmine also detected mucin in only 83% of cases. It was concluded that the apparent incidence of adenocarcinomas may be influenced by staining methods used. Some standardization of technique is desirable and the AB-PAS combination appears to be the most satisfactory.

Adenocarcinoma↗
PubMed1973

"Sclerosing haemangioma" of the lung: an alternative view of its development.

;Sclerosing haemangioma' is a name which has been applied to a group of uncommon benign pulmonary lesions characterized by their papillary nature, a sclerotic stroma containing lipid, and, in some cases, evidence of haemorrhage. There is little evidence that these lesions are really angiomatous. Studies of two examples removed surgically after being discovered as incidental radiographic findings, show that the cells lining the papillae have large vacuoles which contain whorled, electron-dense inclusions. These epithelial cells have the features of granular pneumonocytes, cells known to contain phospholipid. Both lipid and cholesterol are abundant in the stroma of both tumours and the lipid is distributed in a nodular fashion. Histochemically the lipid gives a strong reaction to stains for phospholipid and it is suggested that the lipid is derived, not from the haemorrhage, but is produced by the epithelial element of the tumour.

Adult↗