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Biomedical subjects

A Kaya

Publications and source records attributed to A Kaya.

42 records · Page 3Linked to original sources

Spermatic granuloma in the ram: diagnosis by ultrasonography and semen characteristics.

Ultrasonographic appearance of the testis and epididymis, and seminal characteristics, with regard to localization of spermatic granuloma were studied. In rams with spermatic granuloma (n = 9), diagnosed by clinical or ultrasonographic examinations before histopathological confirmation, localization of each lesion was recorded. Epididymal granulomas, caput and cauda, were seen as anechoic or hyperechoic areas with a distinct margin with or without a hyperechoic capsule. Granulomas in the testis were microscopic and, therefore, could not be detected by ultrasonography. Enlargement in the mediastinum testis was detected in all rams when there were granulomas in the caput. Heterogeneous testis parenchyma invaded by numerous hyperechoic foci, representing testicular degeneration, was associated with granulomas both in the epididymis and testis. Ultrasonographic appearance of the lesions did not differ with regard to season. Seminal characteristics varied between rams. It was concluded that ultrasonographic evaluation may give valuable information in the diagnosis of sperm granuloma in the ram.

Analysis of Variance↗

Pulmonary tuberculosis with multifocal skeletal involvement.

Skeletal tuberculosis accounts for 1-5% of all tuberculosis infections. Of these infections, 50% involve the vertebral column and only 0-5% involve ribs. Rib tuberculosis is seen in only 0.1% of all tuberculosis infections. Skeletal tuberculosis is localised to a single site in 90-95% of reported cases. Multifocal involvement is uncommon and is usually associated with disseminated disease. We present a case of pulmonary tuberculosis associated with multifocal skeletal involvement.

Adult↗

Beta-ketothiolase deficiency. A case report.

A four-month-old boy with beta-ketothiolase deficiency is described in this report. Presenting symptoms and signs were vomiting, irritability and acidotic respiration. Laboratory investigations revealed hyperglycinemia, metabolic acidosis and ketosis. Subsequent urinary GC-MS analysis of the patient's urine sample showed the typical pattern of beta-ketothiolase deficiency. Our experience with this case indicates that accurate diagnosis and early treatment of inborn errors might be lifesaving.

Acetyl-CoA C-Acyltransferase↗

Cyclosporin in steroid dependent asthma.

Cyclosporin A(CsA) is an immunosupressive drug which inhibits predominantly T lymphocyte dependent immune responses. In recent years, CsA is reported to have significant steroid sparing effect in severe asthma. We used CsA top treat 12 steroid dependent asthmatic patients who had been on systemic steroids for an average of 8.5 years. During the baseline period lasting 3 months, therapy was standardized with inhaled beclamethasone, salbutamol and aminophylline and minimal necessary dose of steroid for each patient was determined. Treatment period lasted three months with 3 mg/kg/day CsA orally, the mean CsA whole blood level through the study was 77.25 ng/ml. In patients the daily dose of prednisone could be reduced from mean 31.43 mg to mean 8.57 mg (p < 0.01), while an average 34% improvement was observed in FEV1 values. However in one patient attempts to taper steroid doses were unsuccessful. Four patients were withdrawn from the study due to side effects of CsA. We suggest that CsA in steroid dependent severe asthma can reduce the requirement for systemic corticosteroids, however side effects of the drug must be weighed against its possible benefits.

Adult↗