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Biomedical subjects

A Kaufmann

Publications and source records attributed to A Kaufmann.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[The Holt-Oram syndrome. Review of the literature and current orthopedic treatment concepts].

PROBLEM: The clinical manifestation of the Holt-Oram-syndrome (HOS) shows congenital heart-disease and anomalies of the upper limb. The inheritance of this syndrome is autosomal dominant. The question arise, as to whether a contemporary orthopedic concept of treatment could developed based on own experiences and data from the literature. METHODS: We revised data from five patients with HOS treated at the Clinic for Orthopaedics of the University of Heidelberg. The review of the literature revealed a comprehensive and detailed picture of the clinical syndrome and, furthermore, information in respect to a comparative analysis of methods of treatments. RESULTS: Our patients showed characteristic cardiac anomalies, i.e. atrio and ventricular septal defects, and persisting Botall's duct (three cases). The types of malformation of the upper limb corresponded with those found in the literature. Furthermore the indication for amputation of rudimentary or hypoplastic fingers in the Heidelberg clinic was in accordance with the clinical treatments described worldwide. CONCLUSION: The type of treatment of the clubhand in cases with HOS depends on (1) the age and (2) the pattern and degree of accompanying malformations of the upper limb. For patients with aplasia of the thumb or amputation of a rudimental one we recommend pollicisation of the index finger to improve its function.

Child↗
PubMedDate not supplied

Lead in wine.

Elevated levels of lead in wine have been explained by several possible contamination sources: leaded gasoline, tin-lead capsules (used to cover the bottle neck), and brass alloys. Lead measurements from 7000 wines were used to identify possible sources and these showed that atmospheric pollution-related contamination (leaded gasoline) was not responsible for elevated lead concentrations in wine. It also was shown that the presence or absence of tin-lead capsules as well as the state of tin-lead capsule corrosion had only a very minor influence on the lead concentration in wine. The reported positive correlation between wine age and lead concentration was confirmed by our data. However, further statistical analysis revealed that not the age of wine but the vintage and the wine colour were the most significant contributing factors. The wine age itself was no longer correlated with the lead concentration after controlling for the significant variables mentioned. The conclusions drawn agree well with the explanation that brass is the main contamination source. Inspections of wineries known for elevated lead levels always revealed the presence of brass tubes and faucets. There has been a continuing and significant reduction of lead levels in wine during the recent 7 years where measurements were made.

Alloys↗
PubMedDate not supplied

Cytarabine treatment of human T-lymphoid cells induces decreased HIV-1 receptor expression and reduced HIV-1 susceptibility.

Continuous cultivation of T-lymphoid C8166 cells in the presence of pharmacological relevant concentration of cytarabine (Ara-C) results in significantly decreased expression of CD4 and CXCR4 molecules, the major cellular receptor and co-receptor of T-lymphotropic HIV-1 isolates. This change in receptor expression leads to decreased susceptibility of Ara-C resistant cells to HIV-1 infection demonstrated by reduced binding and penetration of HI-virus.

Antiviral Agents↗
PubMedDate not supplied

[Clinical, diagnostic and therapeutic problems in the postthrombotic syndrome. Our experience].

An analysis is presented, of the experience acquired in the II-nd Surgical Clinic of Cluj-Napoca in connection with 150 cases of postthrombotic syndrome followed and treated over the last 5 years (1983-1987). Considerations are made concerning terminology, and evaluation of diagnostic and therapeutic means applied. The post-thrombotic syndrome develops in a variable interval after the thrombophlebitis (months and even years). A series of factors prevent of enhance the development of the syndrome (98% diagnostic errors and therapeutic failures). Phlebography is mandatory in cases where surgery is considered. Noninvasive explorations (Doppler, plethysmography) limit the use of phlebography. The most efficient treatment is prophylaxis (consisting in the prophylaxis and the correct treatment of thromboembolic disease). The usual treatment is mainly medical and conservative (59.4%). Surgery is carried out in cases where the superficial, the communicating and the deep venous systems are involved.

Adult↗
PubMedDate not supplied

[Venous emergencies. Personal experience and viewpoint].

Based on a casuistic report of 226 cases, the authors propose a classification of venous emergencies, including acute deep thrombo-phlebites (with their anatomo-clinical and topographical varieties), the complications of varicose disease, venous traumatism and anorectal venous thrombosis. The authors touch on problems associated with clinical and paraclinical diagnosis, prophylaxis and active surgical therapy, respectively thrombectomy, ligation of the long saphenofemoral junction, the treatment of varico-phlebitis and urgent traumatic lesions, the thrombectomy and radical cure of haemorrhoids. The coupling of any of these affections presents a potential of great seriousness, sometimes a major vital risk which necessitates immediate therapeutic intervention. The classification of the idea of "venous emergency" in comparison with that of "arterial emergency", is outlined, and the authors mention that a surgical treatment in these affections is to be preferred.

Emergencies↗