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Biomedical subjects

A K Pandey

Publications and source records attributed to A K Pandey.

At least 55 records · Page 3Linked to original sources
PubMed1991

Insecticide-induced inhibition of thyroid activity in the fish Oreochromis mossambicus and recovery in insecticide-free water.

The histological and histochemical state of the thyroid gland of Oreochromis mossambicus was analyzed after 20 days' exposure of the fish to BHC (p less than 0.001 ppm). Histological changes after exposure included acolloidal and atrophied follicles and goitre formation. Follicular and nuclear diameter and the E/T ratio were significantly (p less than 0.001) higher than in the corresponding controls. The above insecticide led to thyroid dysfunction. The histochemical characteristics of the gland also changed after BHC treatment. When exposed fish were transferred to normal, clear, dechlorinated water, the altered follicles displayed remarkable recovery of activity and thyroid function returned to almost the same state as in normal controls. Histological and histochemical evaluation at 10-day intervals revealed healthy functional restitution of the gland, indicating that BHC-induced changes are reversible.

Animals↗
PubMed1989

Sonatox-induced impairment of ovarian activity in an exotic cichlid, Oreochromis mossambicus.

In a low dose and short chronic exposure, Sonatox (2,2,5-endo, 6-exo-8,9,10-heptachloroborane), a chlorinated insecticide, impaired ovarian activity in the fish Oreochromis mossambicus. The histological profile showed abnormalities of the different kinds of oocytes and their nuclei. Compared with the controls, a sharp drop in the proportion and diameter of the various oocytes was observed. Fish exposed to Sonatox had more atretic oocytes than were found in the controls. Percentual gonad weight in relation to body weight was also significantly reduced in treated fish (p less than 0.001). These changes are indicative of regression of the gonads after exposure to the insecticide.

Animals↗
PubMed1989

Calcaneal osteotomy and tendon sling for the management of calcaneus deformity.

A one-stage operation for severe post-poliomyelitic calcaneus deformity was done in seventy-seven feet of seventy-seven patients. The operation consisted of osteotomizing the calcaneus to increase the lever arm and to reshape the hind part of the foot and using a posterior sling formed from the peroneus brevis and tibialis posterior to provide plantar-flexion power. We were able to evaluate sixty-six patients more than three years after the operation. Most of the patients had improvement in the appearance and function of the foot as a result of the operation.

Adolescent↗
PubMed1988

Rationalisation of regimens of treatment of kala-azar with sodium stibogluconate in India: a randomised study.

The efficacy and safety of six regimens of treatment for kala-azar (visceral leishmaniasis) with sodium stibogluconate were evaluated in a prospective randomised study to ascertain the optimal treatment for Indian patients. Altogether 371 patients with kala-azar were randomised to receive sodium stibogluconate intramuscularly at a dose of 10 mg/kg body weight/day for 20 or 40 days (groups A and A1, respectively), 15 mg/kg body weight/day for 20 or 40 days (groups B and B1, respectively), or 20 mg/kg body weight/day for 20 or 40 days (groups C and C1, respectively). Patients were examined blind before and at the end of treatment and every month for six months. The number of patients who were apparently cured--that is, those whose temperature had returned to normal at the end of their regimen of treatment--was 45 (78%) in group A, 53 (87%) in group A1, 50 (81%) in group B, 60 (95%) in group B1, 58 (92%) in group C, and 62 (97%) in group C1. At six months 62 patients (97%) in group C1, 51 (81%) in group C, 54 (86%) in group B1, 42 (68%) in group B, 45 (74%) in group A1, and 33 (57%) in group A had not relapsed and were cured as confirmed by a bone marrow aspirate free of parasites. The differences between groups C1 and C, B1 and B, and A1 and A were significant. Logistic regression of the proportion cured with the dose and length of treatment showed that both factors were significant in improving the rate of cure; the highest dose for the longer time (group C1) had the best rate of cure. One patient in group C1, 12 in group C, nine in group B1, 18 in group B, 15 in group A1, and 23 in group A were cured with extended courses of 20 mg sodium stibogluconate. One patient in each of groups C1, B, A1, and A became unresponsive to antimony and were cured with pentamidine. One patient in each of groups C1, B, and A became unresponsive to both antimony and pentamidine. The patients tolerated the longer duration of treatment safely, and side effects were minor. Sodium stibogluconate should be given intramuscularly in the dosage of 20 mg/kg for at least 40 days, when patients should be assessed for further treatment if necessary. Such a regimen should achieve the highest rate of cure with low toxicity and low rates of relapse and unresponsiveness.

Antimony Sodium Gluconate↗