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Biomedical subjects

A K Cheban

Publications and source records attributed to A K Cheban.

49 records · Page 3Linked to original sources
PubMedDate not supplied

[Testosterone content of the blood in women with Itsenko-Cushing disease].

The paper is concerned with the results of a study of the testosterone content in the blood of 68 women with the Itsenko-Cushing disease at different stages of therapy. The testosterone level was elevated in the blood of untreated patients at the stage of exacerbation and remission following various therapeutic modalities including khloditan and returned to normal after bilateral total adrenalectomy. It is assumed that the source of testosterone hyperproduction in the Itsenko-Cushing disease is the adrenals.

Adolescent↗
PubMedDate not supplied

[Interrelation of disorders in gonadotropin and prolactin secretion and the activity of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing disease].

An obvious relationship between changes in ACTH, gonadotrophin, prolactin and cortisol secretion was discovered on the basis of studying the basal ACTH, cortisol, LH, FSH and prolactin levels, as well as from correlative examination of the data obtained in 30 females with Icenko-Cushing's diseases. It is suggested that combined ACTH, gonadotrophin and prolactin secretion occurs in the active stage of the disease, whereas cortisol inhibits gonadotrophin production. A degree of gonadotrophic insufficiency is dependent on the ratio of excessive ACTH-cortisol secretion.

Adolescent↗
PubMedDate not supplied

[Dynamics of secretion of hypothalamo-hypophyseal system hormones in Itsenko-Cushing disease as affected by combination therapy].

The results are presented of the studies on corticotropin, cortisol, beta-lipotropin, beta-endorphine, somatotropin, somatostatin, prolactin and thyrotropin secretion in 46 patients with active Icenko-Cushing's disease at the nearest and late periods after the treatment with an antiserotonin drug--cyproheptadine (peritol) combined with an adrenocortical secretion inhibitor--khloditan. The hormone basal levels and secretion under the action of stress, induced by insulin hypoglycemia or thyroliberin injection, were determined in the patients under examination by radioimmunoassay. In patients with an acute stage of the disease the blood beta-lipotropin, beta-endorphine, corticotropin, cortisol, somatostatin and prolactin concentrations are elevated, whereas those of somatotropin and thyrotropin are lowered. The hypothalamic, hypophyseal and adrenocortical response to stress or thyroliberin injection is reduced. THe combined treatment with khloditan and high doses of cyproheptadine led to pronounced clinical and hormonal remission in 55% of the patients. The blood beta-lipotropin, beta-endorphine, corticotropin, cortisol, somatostatin and somatotropin concentrations returned to normal. The blood prolactin and thyrotropin levels, as well as the response to thyroliberin injection remained disordered.

Adolescent↗
PubMedDate not supplied

[Pathogenesis of the arterial hypertensive syndrome in Itsenko-Cushing disease].

The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced plasmatic renin activity were revealed. It is suggested that activation of the renin-angiotensin-aldosterone system stimulates the development of arterial hypertension in patients with Icenko-Cushing's disease, taking into account a significant role of this system in alteration of the central hemodynamics indices.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Results of treatment of Cushing's syndrome with chloditane and large doses of reserpine].

To inhibit corticotropic function of the pituitary and glucocorticoid function of the adrenal cortex in the treatment of 41 patients with Icenko-Cushing's disease, use was made of the steroidogenesis inhibitor chloditane and high doses of reserpine. The treatment data were compared to the effect of chloditane alone in 40 patients. Inclusion of reserpine into the complex of therapeutic measures led to an appreciable decrease in corticotropin secretion which increased again shortly after the drug discontinuation. The clinical results of the treatment were comparable to those attained with administration of chloditane alone. The majority of patients manifested recurrent disease 3 to 12 months after the treatment was discontinued. Therefore, administration of reserpine as an additional means in the treatment was discontinued. Therefore, administration of reserpine as an additional means in the treatment of Icenko-Cushing's disease by chloditane with a view of a steady inhibition of corticotropic function of the pituitary and the prophylaxis of recurrencies is not desirable. High doses of reserpine may be recommended at the initial stages of the disease treatment in the presence of an extremely high level of blood plasma corticotropin.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Mineralocorticoid function of the adrenal cortex and the renin--angiotensin system in Itsenko-Cushing's disease].

Mineralocorticoid function of the adrenal cortex and the activity of the renin-angiotensin system were studied in patients with Itsenko-Cushing's disease before (36 cases) and after (27 cases) the treatment with chloditan--an adrenocortical inhibitor. Minertalocorticoid function of the adrenal cortex was assessed by the blood immunoreactive aldosterone content, urinary 18-aldosterone-glucuronide excretion, and the rate of aldosterone secretion. Condition of the renin-angiotensin system was assesed by the blood renin activity. Aldosterone and renin concentration was studied by the radioimmunological method. There proved to be a reverse relationship between the blood aldosterone concentraiton and the severity of Itsenko-Cushing's disease. Elevation of the mineralocorticoid function of the adrenal cortex in Itsenko-Cushing's disease was due to activation of the renin angiotensin system. During clinical remission of the disease following a course of chloditan treatment the patient displayed an increased blood aldosterone level and a rise of its secretion. The minralocorticoid function of the adrenal cortex was intensified at the state of clinical remission because of an increased blood corticotropin concentration.

Adolescent↗
PubMedDate not supplied

[Prolactin secretion in Itsenko-Cushing disease patients treated with chloditan and peritol].

Prolactin secretion was studied in 46 patients with Icenko-Cushing's disease in the acute stage, at the early and late terms of the treatment with khloditan and low doses of peritol and over a period of partial and clinical remission, resultant of the treatment with khloditan and high doses of peritol. The changes in the blood prolactin concentration were determined on the empty stomach by radioimmunoassay in the presence of insulin hypoglycemia and thyroliberin injection. It was found that the prolactin basal level in the blood of patients with Icenko-Cushing's disease remained elevated at the early and late terms of the treatment with khloditan and low doses of peritol and the adenohypophyseal reactivity to stimulants did not return to normal. Khloditan and high dose peritol treatment did not induce clinical and hormonal remission of the disease but resulted in the blood prolactin basal level increase and even more pronounced decrease in the adenohypophyseal reactivity to stimulants in comparison with those of the active stage of the disease. The blood prolactin concentration in patients with clinical remission lowered down to the level, being seen before the treatment, and the reactivity to stimulants significantly improved comparatively to that of the partial remission, but did not return to normal.

Adolescent↗
PubMedDate not supplied

[Glucocorticoid kinetics in Cushing's syndrome treated with chloditane and large doses of reserpine].

The paper is concerned with the results of the studies on corticosteroid kinetics (secretion rate, distribution volume, metabolic blood clearance, mean daily blood cortisol content and excretion of free hormone with urine) in 44 patients suffering from Icenko-Cushing's disease, treated with chloditane and/or chloditane combined with massive reserpine doses. The above parameters increased in Icenko-Cushing's disease during clinical remission after chloditane or chloditane and reserpine treatment. No differences between effects on glucocorticoid secretion and metabolism after the treatment with chloditane or chloditane in combination with high reserpine doses were recorded.

Adolescent↗