The authors present the results of examination of the content of ACTH and cortizol in the blood of 55 patients with Itsenko-Cushing disease and of 36 healthy persons. Fifty patients were examined repeatedly after a course of chloditan treatment. Plasma ACTH content was determined by the radioimmunological method, and cortizol -- by the competitive binding method with the help of sets. Investigations carried out showed an increase in blood ACTH and cortizol which proved to be most pronounced in patients with a severe form of Itsenko-Cushing disease. A marked reduction of glucocorticoid function of the adrenal glands with an elevation of ACTH secretion occurred after chloditan therapy. At remote periods after the chloditan treatment ACTH and cortizol secretion depended on clinical manifestations of the disease. It was shown that examination of blood ACTH and cortizol content could be used as an auxiliary criterion in the diagnosis of Itsenko-Cushing disease, in ascertaining the severity of this disease and in the assessment of the efficacy of the treatment carried out.

Adolescent↗

PubMedDate not supplied

[Various mechanisms of disorders of the hypothalamo-hypophyseal-adrenal system in Cushing's syndrome].

The authors present the results of study of corticotropine and cortizol secretion under the effect of stress caused by insulin hypoglycemia, of sensitivity of the adrenal glands to the administration of exogenous synthetic corticotropine, and of the 24-hour rhythm of the corticotropine and cortizol secretion in 26 healthy persons and in 57 patients suffering from Itsenko-Cushing's disease, including 25 after a course of treatment with chloditan, an inhibitor of the adrenal cortex function. Blood corticotropine content was determined by the radioimmunological method, and of cortizol--by competitive binding. There was revealed no significant increase of corticotropine and cortizol secretion in response to insulin hypoglycemia in Itsenko-Cushing's disease, this pointing to disturbance of the hypothalamo-hypophysio-adrenal system at the hypothalamic level. No qualitative differences were found in response of the adrenal cortex to corticotropine, this indicating the absence of changes of its sensitivity to this hormone. The 24-hour rhythm of corticotropine and cortizol secretion in this disease is inverted. At the immediate periods after chloditan treatment no normalization of the response of the adrenal cortex to insulin hypoglycemia, and of the 24-hour rhythm of corticotropine and cortizol secretion, and also of the changes in the adrenal cortex sensitivity to corticotropine was seen.

Adolescent↗

PubMedDate not supplied

[Dynamics of the corticotropin, cortisol and prolactin content of the blood plasma of women with Itsenko-Cushing disease administered luliberin].

The paper is concerned with the results of a study of the level of plasma ACTH, cortisol and prolactin before and after i. v. injection of LHRH to 20 patients with Itsenko-Cushing disease and to 5 healthy persons. In healthy persons LHRH injection caused no significant changes in the level of plasma ACTH, cortisol and prolactin. Patients with Itsenko-Cushing disease who had a high basal level of corticotropin on the 30th min after i.v. LHRH injection demonstrated a significant increase in the hormone level. A response to LHRH injection was absent in patients with a normal basal level of corticotropin and in healthy persons. A statistically significant increase in cortisol concentration was noted on the 60th min after LHRH injection in some of the patients responding to LHRH by a high ACTH level. LHRH injection was not accompanied by significant changes in the level of plasma prolactin in either of the subgroups.

Adrenocorticotropic Hormone↗

PubMedDate not supplied

[Experimental and clinical basis for using the preparation nacom in the treatment of Itsenko-Cushing disease].

The paper is concerned with the results of an experimental study of the nacom (NC) effect on the activity of the hypothalamohypophysioadrenal system and the results of its application to 29 patients with Icenko-Cushing's disease with curative purposes. In rats the concentration of corticotropin and aldosterone was determined with a radioimmunoassay, that of corticosterone with a competitive protein binding method. The dopamine content in the hypothalamus and cerebral cortex was studied by fluorimetry. To define the hypothalamohyphysioadrenal system in the patients a study was made of blood corticotropin, cortisol and aldosterone basal levels as well as response of the system to insulin hypoglycemia induced stress. Dopaminergic NC was shown to be dose-related with the activity of the hypothalamohypophysioadrenal system. The NC effect was associated with an increase in the dopamine level in the hypothalamus and cerebral cortex. Clinical investigations proved NC efficacy for therapy of Icenko-Cushing's disease permitting one to recommend it as a pathogenetic agent for therapy of this disease.

Adrenocorticotropic Hormone↗

PubMedDate not supplied

[New method of treating Itsenko-Cushing disease by transvenous destruction of the adrenals].

A new method was developed for therapy of Icenko-Cushing's disease using transcatheter transvenous destruction of the adrenals (TTDA) to replace commonly used adrenalectomy. TTDA was performed by means of venous extravasation of a radiopaque agent (76% verografin solution) and its deposition in the organ parenchyma. TTDA was performed in 57 patients with Icenko-Cushing's disease using 3 tactical approaches including roentgenovascular intervention: bilateral TTDA, unilateral TTDA combined with unilateral adrenalectomy and unilateral TTDA combined with chloditan. TTDA is an effective method of invasive suppression of function of the cortex of the endocrine glands. TTDA superiority over surgical methods of therapy Icenko-Cushing's disease is that an effect of adrenalectomy is achieved without a risk of surgical intervention and narcosis.

17-Hydroxycorticosteroids↗

PubMedDate not supplied

[Roentgeno-endovascular destruction of the adrenal glands in Itsenko-Cushing disease].

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Adrenalectomy↗