Search PubMed⌕ Search

Biomedical subjects

A Jones

Publications and source records attributed to A Jones.

At least 613 records · Page 34Linked to original sources
PubMed1980

Comparison between continuous flow and intermittent flow transurethral resection in 40 patients presenting with acute retention.

Forty patients admitted with acute retention of urine were treated by transurethral resection of the prostate by either the continuous or intermittent flow resectoscope. No significant differences or trends were demonstrated between the 2 techniques in respect of speed of resection, blood loss and amount of glycine absorbed. There was a marked degree of haemodilution during surgery in some patients.

Acute Disease↗
PubMed1980

Study of migraine and the treatment of acute attacks in industry.

A simple study of migraine was undertaken in an industrial setting to identify facts about the condition of migraine which had previously been unrecorded in industry. The study was based on a definition of migraine encompassing headache accompanied by visual or gastro-intestinal disturbances. During the period from April 1979 to December 1979 there were 111 separate incidents reported to this department, with 281 working days lost in this period, which would give an average annual loss of 420 working days through migraine. Approximately 6% of the work-force were seen to be affected by migraine. Using a simple treatment it was possible to return the majority of the work-force to the place of work within 1 hour, with no subsequent problem caused to their health, either through migraine or accident.

Absenteeism↗
PubMed1980

Information-seeking behavior in the tactile modality.

In two experiments male undergraduate students (ns = 24 and 28) were placed in a sensory deprivation environment to assess operationally defined drive properties of statistically defined information in the tactile sensory modality. In the first experiment it was demonstrated that there is a relationship between rate of responding for tactile information and duration of sensory deprivation, and a positive linear relationship between response rate and the relative information value of tactile stimuli. In the second experiment it was observed that information satiation in the tactile modality reduces drive for visual information. These results were discussed in relation to previous studies of auditory and visual information drives and were taken to support the existence of a generalized drive for information.

Drive↗
PubMed1979

Ingrowing toenails: the results of treatment.

Completed questionnaires were received from 208 patients on whom 245 operations for ingrowing toenails had been performed at King's College Hospital. Avulsion of a strip of nail had an 83 per cent recurrence rate, total nail avulsion 70 per cent, Zadik operations 28 per cent and wedge resections 29 per cent. It is recommended that immediate avulsion of ingrown toenails should not be a routine practice.

Adolescent↗
PubMed1979

The effects of dopamine, bromocriptine, lergotrile and metoclopramide on prolactin release from continuously perfused columns of isolated rat pituitary cells.

The control of secretion of prolactin was studied using continuous perfusion of a column of isolated rat pituitary cells supported by Bio-Gel polyacrylamide beads. Prolactin secretion was inhibited repeatedly by dopamine and rapidly recovered in its absence. Maximum inhibition was achieved at 5 x 10(-7) M dopamine. Bromocriptine and lergotrile directly inhibited prolactin release from the pituitary cells. Bromocriptine had a longterm action in inhibiting secretion. The dopamine receptor blocking agent, metoclopramide, overcame the inhibitory effect of dopamine but had no effect on prolactin secretion in its absence.

Animals↗
PubMed1979

The effect of lisuride hydrogen maleate, an ergot derivative on anterior pituitary hormone secretion in man.

The effects of single oral doses of 0.2 mg of lisuride hydrogen maleate, a semisynthetic ergot derivative, on serum levels of prolactin (PRL), growth hormone (GH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), cortisol and blood glucose were studied in six normal males. Lisuride effectively inhibited basal PRL secretion as well as the PRL response to TRH given 3 h later. In addition, the drug raised basal GH levels and decreased basal and TRH stimulated TSH secretion. No significant differences between lisuride and control were observed in basal LH and FSH, LHRH stimulated gonadotrophins or in cortisol. Drowsiness was noted by all subjects, one became nauseated and another vomited, 60 and 90 min respectively after administration of lisuride. No changes were seen in pulse rate and blood pressure. The endocrine effects of lisuride were attenuated by the prior administration of the dopamine antagonist metoclopramide. These results suggest that lisuride acts as a long-acting dopamine agonist and that therefore this drug could be of therapeutic use in hyperprolactinaemic states and acromegaly.

Adult↗
PubMed1979

Effects of the H2 receptor antagonist cimetidine on pituitary hormones in man.

The effects of the histamine (H2) receptor antagonist cimetidine on serum levels of prolactin (PRL), growth hormone (GH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH) and cortisol were studied in five normal males. Cimetidine, when given by infusion at the dose of 100 mg/h for 5 h, did not alter adenohypophyseal secretion either basally or after pituitary stimulation with LHRH and TRH. However, 400 mg cimetidine given intravenously as a bolus injection significantly stimulated PRL release in all subjects, without affecting any other measured hormone. A dose-reponse relationship existed, and 200 mg cimetidine seems to be the minimum PRL-releasing dose when given as an intravenous bolus injection. These results suggest that cimetidine releases PRL and that this effect is dose-related, but only when large intravenous injections are given.

Adult↗
PubMed1978

Hormonal and metabolic responses to an enkephalin analogue in normal man.

An enkephalin analogue [D-Ala2, MePhe4, Met(o)-ol] enkephalin (DAMME), given intravenously to normal subjects raised serum prolactin and growth-hormone levels but lowered serum levels of luteinising hormone, follicle-stimulating hormone, cortisol, and corticotrophin. There was also a small fall in total glucagon and gastric inhibitory peptide (G.I.P.) and a rise in thyrotrophin. beta-Lipotrophin, motilin, vasoactive intestinal peptide, insulin, gastrin, and pancreatic glucagon were unchanged. Blood-glycerol increased, and blood lactate, alanine, and glucose fell. Prior administration of the opiate antagonist, naloxone, attenuated the hormonal responses to DAMME. This enkephalin analogue produces endocrine and metabolic changes in man which may be mediated through opiate-binding receptors both within and outside the brain. The enkephalins and related substances may provide an important link between perception, behaviour, and neuroendocrine regulation of hormone secretion and metabolism.

Adrenocorticotropic Hormone↗