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Biomedical subjects

A Jardin

Publications and source records attributed to A Jardin.

At least 127 records · Page 7Linked to original sources
PubMed1989

[Comparative study of the University of Wisconsin solution versus Eurocollins in kidney transplant].

UW (University of Wisconsin) solution, formulated by Belzer's team in Madison, has already been proved to increase cold ischemia time in liver and pancreas preservation. A multicentre clinical trial is being conducted to compare renal preservation in human transplantation using two different solutions: UW and Eurocollins (EC). This paper, whose results will be included in the multicentre trial, reports local comparative results between UW and EC perfused Kidneys. The two donor populations UW (28 cases) and EC (47 cases) were not randomized. They were however comparable in renal function prior to harvesting but not in age (35 +/- 13.4 years EC versus 27.7 +/- 12.4 years UW). The two recipient populations (48 EC versus 48 UW) were more homogeneous. Comparative results were significant with better graft function in the UW group: creatinine at one week: 499.2 +/- 296.3 EC versus 277.6 +/- 226.2 mumol/l, p less than 0.0001; creatinine at one month: 228.7 +/- 135 EC versus 159.7 +/- 135.6 mumol/l, p less than 0.02 and a decrease in acute tubular necrosis (39.5% EC versus 14.5% UW) and hospital stay. These results justify the use of UW solution by intraaortic flush especially during multi-organ procurement.

Adenosine↗
PubMed1989

[Lymphocele and kidney transplantation].

The authors report fourteen cases of lymphocele in a series of one thousand consecutive renal transplantations (1.4%). The prevention of these lymphoceles depends on rigorous lymphostasis. The diagnosis is based on ultrasonography. The treatment indicated in cases of voluminous lymphoceles consisted in marsupialization and omentoplasty.

Adult↗
PubMed1989

[Value of the scanner in acute pyelonephritis].

Twenty patients with clinical acute pyelonephritis were investigated by routine CT scan. This examination was positive in 19 cases, demonstrating either a hypodense triangular image reflecting a disorder of blood supply or a mass syndrome. The CT scan can therefore confirm the diagnosis of acute pyelonephritis. It also defines the severity of the lesions and helps to guide treatment.

Acute Disease↗
PubMed1989

[Resection of the prostate after 75 years].

The authors report a series of 100 endoscopic resections performed in patients over the age of 75 years. In patients with no risk factors, there was no mortality and the morbidity was 5%. In patients with one risk factor, mortality was 5% and morbidity was 10%.

Aged↗
PubMed1989

[Analysis of lymphocyte subpopulations of the bladder following endovesical immunotherapy using BCG].

The authors studied, by means of immunohistochemical analyses, the lymphocyte subpopulations in bladder biopsies from 20 patients treated for a urothelial bladder tumour (Tis TA, T1) by intravesical BCG (group A). The biopsies were taken from optically healthy zones and were then frozen. The lymphocyte populations in the urothelium and chorion were studied by means of monoclonal antibodies T3, T4, T8, TQ1, Leu-7, OKM-1, HLA-DR, TAC, Pan-B. Four patients without bladder cancer constituted the control group (group B) and 10 patients with bladder cancer not treated by intravesical BCG constituted group C. In group A, the T4 + TQ1 lymphocytes predominated in the urothelium and in the chorion. An inversion of the T4/T8 ratio was observed in the urothelium of groups B and C (p less than 0.01) and in the chorion of group B (p less than 0.01). There was no significant difference in the T4/T8 ratio in the chorion in groups A and C. In group A, 17 patients expressed the presence of receptors for interleukin 2 (TAC + HLA-DR) on their T lymphocytes. In these cases, the lymphocytic infiltration was associated with the presence of eosinophils (p less than 0.05) and the total absence of NK cells was observed. No B lymphocytes were detected, apart from a few rare lymphoid follicles.

Administration, Intravesical↗
PubMed1988

Mycotic aneurysm and renal transplantation.

A case of mycotic aneurysm secondary to suppuration of a renal transplant is reported. This aneurysm was responsible for ischemia of the leg and was treated successfully by ligation and venous bypass grafting.

Adult↗
PubMed1988

Anatomical study of the infra-montanal urethra in man.

Five samples infra-montanal prostatic urethra fixed in formalin and stored in liquid nitrogen at -30C were examined histologically. The results of this study demonstrated that muscle fibres of the striated sphincter extend as far as the level of the verumontanum. The proportion of rapid and slow striated fibres was identical. These striated fibres were mixed with smooth muscle fibres of the urethra. The density of innervation of this muscular tunic was found to increase closer to the striated sphincter; it is composed of equal numbers of adrenergic and cholinergic fibres.

Adrenergic Fibers↗
PubMed1988

[Efficacy of an alpha-blocker, alfuzosin, on urinary disorders in men with prostatic adenoma. Intermediate results of a European multicenter study].

The use of alfuzosin (a competitive post-junctional alpha-blocker) is based on the finding of alpha-adrenoceptors in trigone, urethra and adenoma tissue. Thirty-one European centers participated in this randomized study with parallel groups (alfuzosin versus placebo). The treatment period lasted 6 months with assessments on D14 and every 6 weeks thereafter. The dose was either 7.5 mg or 10 mg/day. Four hundred and seventeen patients were included (alfuzosin = 205, placebo = 212). The demographic data and the characteristics of the benign prostatic hypertrophy were comparable in both groups. There were 30 drop-outs due to inefficacy in the placebo group and 15 in the alfuzosin group. The difference is significant (p = 0.01). Five patients had to leave the study for emergency treatment of acute urinary retention (4 in the placebo group and 1 in the alfuzosin group). Early improvement was observed in the total score (urgency (p = 0.001) and quality of the stream), assessed on the basis of the functional symptoms (diurnal frequency and nocturia, hesitancy, post-void dribbling, urgency, sensation of incomplete emptying of the bladder and quality of the stream). Alfuzosin was demonstrated to be effective with respect to out-flow obstructive symptoms (quality of the stream, hesitancy, sensation of incomplete emptying of the bladder) and other functional symptoms (diurnal frequency and nocturia). The good total score results favor alfuzosin primarily because of its action on urgency and dysuria. The drug was well tolerated clinically. In conclusion, alfuzosin is useful in moderate dysuria in young subjects, during acute episodes in elderly patients and in patients when surgery has to be delayed.

Adrenergic alpha-Antagonists↗
PubMed1988

[Surgery ex situ in kidney transplantation].

123 vascular surgical procedures were performed ex situ in the course of 534 renal transplantations performed between 1982 and 1987. This study demonstrates that the elongation of the renal vein facilitates the transplantation and significantly reduces the risk of arterial stenosis and that arterial repairs, in the case of multiple arteries, constitute a reliable technique. The elongation of the renal vein means that all donor right kidneys must be procured with the infra-renal inferior vena cava. Donor kidneys with multiple arteries without patch graft can be repaired on the table in the great majority of cases.

Humans↗