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Biomedical subjects

A Jankowski

Publications and source records attributed to A Jankowski.

At least 127 records · Page 7Linked to original sources
PubMed1976

The effective synthesis of uridylyl/3'-5'/5-methylcytidylyl/3'-5'/guanosine.

The triester method was adapted to the synthesis of uridylyl/3'-5'/5-methylcytidylyl/3'-5'/guanosine. As the protecting groups 4-methoxy-5,6-dihydro-2H-pyran for 2'-OH and 5'-OH groups of uridine and 2'-OH group of 5-methylcytidine, methoxymethylidene for I:3'-cis-diol system of guanosine, and benzoyl for the amino groups of 5-methylcytidine and guanosine were used. The obtained product was characterised by UV, electrophoresis, chromatography, an enzymatic digestion and alkaline hydrolysis.

Cytidine↗
PubMed1976

Proteinuria in the acute phase of viral hepatitis in children and the influence of HBAg antigen.

In 55 children in the acute phase of viral hepatitis with HB Ag antigenemia, and in 24 without antigenemia, total urinary protein excretion and frequency of excretion of the following serum proteins in urine were studied: alpha1-glycoprotein, haptoglobin, transferrin, A, G and M immunoglobulins, light immunoglobulin chains of the phi and gamma types, and Fc and Fab fragments of immunoglobulin G. The control group consisted of 15 healthy children without HB Ag antigenemia and 8 with antigenemia. The type of proteinuria was determined by electrophoresis of serum proteins excreted in the urine on Cellogen-RS. In children suffering from viral hepatitis the urine contained serum proteins significantly more often than in healthy children. HB ag antigenemia had no influence on the degree or type of proteinuria. In children suffering from viral hepatitis with and without HG Ag antigenemia, proteinuria was of the selectively glomerular type, and less often of mixed glomerulo-tubular type with selective glomerular component. It follows that the HB Ag antigen has np distinctly detrimental effect on the renal glomeruli in the acute phase of viral hepatitis, in which the vascular endothelium of renal glomerular blood vessels is probably injured. Less ofter, in children in the acute phase of viral hepatitis function of the proximal segment of the tubules is damaged with appearance in the proteinogram of Berggard's microglobulins.

Acute Disease↗
PubMed1976

Immunoglobinuria in the acute phase of viral hepatitis in children and the influence of HBAg antigen.

Urinary excretion of immunoglobulins of the A, G and M classes was studied in 14 children suffering from viral hepatitis without HBAg antigenemia, and in 12 children with viral hepatitis accompanied by HBAg antigenemia. The control group consisted of 11 healthy children. Over fourfold increase in excretion of IgA, and only twofold increase in IgG were observed. The difference in excretion of A and G immunoglobulins, despite their similar molecular weight, was attributed to increased active excretion of IgA by the kidneys, probably due to stimulation by the virusemia. In no case were immunoglobulins of the M class encountered in the urine.

Acute Disease↗
PubMed1976

Activity of cobalt-activated acylase and Australia antigen (HBAg) in children suffering from viral hepatitis.

Activity of Coiactivated acylase in the serum was investigated in 120 children aged 3 months to 15 years, divided into five age groups, suffering from viral hepatitis (VH). No differences were found in the mean values of acylase activity between the ages of 3 months and 6 years, and progressively rising values in older age groups. Statistical analysis showed significance of the difference between the youngest age group and the group of children aged 12-15 years. A study of the dynamics of acylase activity in the course of the disease in 20 children showed rapidly declining values of this enzyme activity. Presence of HBAg in the serum was demonstrated in 12 children, in whom levels of acylase activity in the serum were similar to those in children without HB antigenemia, but the small number of cases examined does not permit conclusions. Acylase activity increases with age. This enzyme activity was observed in the serum of 96%, and HBAg in 10% of the examined children.

Adolescent↗