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Biomedical subjects

A Jamieson

Publications and source records attributed to A Jamieson.

79 records · Page 5Linked to original sources
PubMedDate not supplied

A rational approach to the principles and practice of crime scene investigation: I. Principles.

This paper proposes a structured approach to crime scene investigation that may be applied to the wider aspects of criminal investigation. The approach is an adaptation of the hypotheticodeductive method. The investigator begins with observation of the scene leading to a cycle of hypotheses creation and testing with other information being supplied only after the initial scene examination and hypotheses creation. The recording of observation, hypotheses creation and testing, and information received creates an audit trail of the investigative process. The method seeks to minimise observer bias by providing a rational and recorded approach to crime scene investigation.

Journal Article↗
PubMedDate not supplied

Clinical, biochemical and genetic features of five extended kindred's with glucocorticoid-suppressible hyperaldosteronism.

Glucocorticoid-suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension caused by the inheritence of a chimaeric 11 beta-hydroxylase/aldosterone synthase gene. Affected individuals appear to have an increased risk of premature morbidity and mortality from stroke, but treatment with low doses of dexamethasone can completely reverse the biochemical and clinical features. We assessed the clinical and genetic features of 5 British kindreds with GSH, the largest collection outwith the United States, and determined the location of the crossover regions in the chimaeric gene of all 5 kindreds. All of the kindreds were of celtic origin, another feature peculiar to GSH. In total 19 out of 60 individuals screened by genotyping were found to possess the chimaeric gene and sequencing of the chimaeric gene revealed that all the crossover regions were within the exon 3- exon 4 region of, in keeping with previous studies, and three kindreds possessed indistinguishable chimaeric genes.

Chimera↗
PubMedDate not supplied

The role of surgery in the management of closed injuries to the brachial plexus.

Complete brachial plexus lesions occur infrequently and have until recently been treated by amputation followed by fitting of a prosthesis. The results of such treatment are unsatisfactory. Recently, surgical repair of the plexus has been reintroduced; our experience with complete brachial plexus lesions treated by exploration and nerve grafts are as follows. Early surgical repair of the plexus does produce reasonable results, while late repair is unrewarding. The future of the management of brachial plexus lesions lies in early diagnosis and exploration of these lesions. In medical institutions with personnel interested in the problem of brachial plexus injury, further surgical research is bound to lead to new and improved treatment.

Brachial Plexus↗
PubMedDate not supplied

Dissecting hypertension: the role of the 'new genetics'.

The tools of molecular genetics have recently been applied to hypertension, a common multifactorial disorder, with some success. Glucocorticoid-suppressible hyperaldosteronism, an inherited form of human hypertension due to the dominant inheritance of a chimaeric steroid 11 beta-hydroxylase/aldosterone synthase gene, has given an insight into the possible genetic factors involved in essential hypertension. Study of the aldosterone synthase and steroid 11 beta-hydroxylase genes has shown the presence of polymorphisms in both of these genes in human subjects; further studies may demonstrate genetic mutations with pathophysiological effects in patients with essential hypertension.

Cytochrome P-450 CYP11B2↗