Search PubMed⌕ Search

Biomedical subjects

A James

Publications and source records attributed to A James.

161 records · Page 9Linked to original sources
PubMed1977

Corneal edema: iris-clip lens implantation and simple intracapsular extraction compared.

Corneal edema following intracapsular lens extraction and iris-clip lens implantation was compared by assessing corneal thickness and epithelial edema. In a retrospective study the corneal thickness of twenty patients who had intracapsular lens extraction in one eye only was compared with twenty-six patients with iris-clip lens implants in one eye. There was no significant increase in corneal thickness in the operated eye in either group. In a prospective randomized controlled study, a smaller number of patients, had serial measurements of corneal thickness pre- and postoperatively. There was an increase in thickness in the immediate postoperative period for both groups. However, there was no significant difference between eyes which had simple extraction and those which had implants. The implanted eyes however had greater mean increase endothelial trauma in the initial period, compared to eyes with cataract extraction alone.

Aged↗
PubMed1976

HLA matching and corneal grafting.

A series of 200 cases of full-thickness corneal allografts have been followed to determine whether HLA and ABO incompatibility influence prognosis of the grafts. 85% of patients with avascular corneas had clear, functioning grafts one year after transplantation. Only 33% of patients with severely vascularised corneas had successful grafts one year after transplantation. A significant association was found between severe vascularisation of the patient's cornea and irreversible graft rejection. In this group of patients, the proportion of grafts functioning was found to be ranked according to the number of HLA antigens shared by graft donor and recipient. Patients receiving grafts matching for 2 HLA antigens showed a failure-rate due to irreversible rejection of 26% at one year, in comparison with 57% and 62% of grafts matching for 1 or 0 HLA antigens respectively. ABO incompatibility or ABO phenotype of the recipient did not influence graft prognosis. The results indicate that patients with severely vascularised corneas should receive HLA-matched corneal grafts. The institution of HLA-typed cornea "banks" for treatment of such patients is advocated.

ABO Blood-Group System↗
PubMedDate not supplied

Two-generation reproductive toxicity study of inhaled tertiary amyl methyl ether (TAME) vapor in CD rats.

Under Office of Prevention, Pesticides and Toxic Substances draft guidelines, CD weanling F0 rats (30 of each gender per group) inhaled tertiary amyl methyl ether vapor at 0, 250, 1500 or 3000 ppm 5 days a week and 6 h a day for 10 weeks, with vaginal cytology evaluated for weeks 8-10. The F0 animals then produced F1 offspring, with exposure 7 days a week from mating through to lactation. During the F1 prebreed exposure period, vaginal patency, preputial separation (PPS) and vaginal cytology were evaluated. The F1 animals were mated, with F2 anogenital distance measured on postnatal day zero. At F2 weaning 30 of each gender per group were selected for postwean retention, with no exposures, through vaginal patency and PPS. Body weights, feed consumption and clinical signs were recorded throughout the study. Adult F0 and F1 systemic toxicity was present at 1500 and 3000 ppm. Minor adult male reproductive toxicity was present at 3000 ppm. There were no adult effects on vaginal cyclicity, estrous cycle length, mating, fertility, pregnancy, gestational length or ovarian and uterine weights. There were no treatment-related gross or histopathologic findings in parental male or female systemic or reproductive organs. The F1 and F2 offspring toxicity was present at 1500 and 3000 ppm. The no-observable-adverse-effect level for adult systemic and offspring toxicity was 250 ppm and 1500 ppm for male reproductive toxicity (females at >3000 ppm).

Air Pollutants↗
PubMedDate not supplied

Model behaviour.

Explore the source record for details and available documents.

Commitment of Persons with Psychiatric Disorders↗
PubMedDate not supplied

A pre-discharge ward for acute medical patients.

UNLABELLED: We describe and evaluate a ward developed to facilitate the discharge planning of general medical patients. DESCRIPTION: A 15-bed pre-discharge ward (PDW) with a ward coordinator was established in 1995, as a counterpoise to a medical assessment unit (MAU). METHOD: Data, analysed after the first year, included diagnosis, physiotherapy and occupational therapy referrals, length of stay and discharge destination. RESULTS: During its first year, 810 patients were admitted to the PDW; 39% were male, their mean age was 75 years (range, 16-99; standard deviation, 11.3). Respiratory illness (24%) was the commonest diagnosis, 62% required physiotherapy, 51% occupational therapy and 35% needed increased social support. Discharge was as follows: 681 (84.1%) patients were discharged to their admission address, 34 (4.2%) were taken over by the department for care of the elderly, 29 (3.6%) discharged to relatives, 23 (2.8%) to residential or nursing homes, 22 (2.7%) returned to acute medical beds, 12 (1.5%) to general practitioner beds and nine patients (1.1%) died. The average length of stay during a three-month period (October-December) for all acute medical patients was 7.47 days before the MAU and PDW were opened and 7.32 days afterwards. CONCLUSIONS: The PDW provides multidisciplinary assessment and focused discharge planning for patients of general physicians. This did not prolong their stay in acute medical beds.

Adolescent↗