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Biomedical subjects

A Itoh

Publications and source records attributed to A Itoh.

At least 235 records · Page 13Linked to original sources
PubMed1988

Body temperature monitoring in subjects with delayed sleep phase syndrome.

To clarify the circadian aspects of delayed sleep phase syndrome (DSPS) in 4 patients with DSPS, we recorded polysomnograms and rectal temperature before and after chronotherapy. The time interval (2.7 h) between sleep onset and rectal temperature minimum before chronotherapy was shorter than the time interval after chronotherapy (5.3 h). Before chronotherapy, the period of rectal temperature rhythm was 24.7 h. After chronotherapy, the period of rectal temperature rhythm was 24.0 h. These findings lead to the conclusion that in DSPS there is a weakened mechanism of entrainment similar to that in non-24-hour sleep-wake syndrome.

Adult↗
PubMed1988

Experimental study of vagotomy for prevention of stress ulcer after hepatectomy of cirrhotic livers. Its influence on hepatic regeneration.

We experimentally studied the influence of vagotomy on hepatic regeneration in rats after hepatectomy of cirrhotic livers. In animals that underwent hepatectomy plus vagotomy the reduction in gastric pH was suppressed, but gastric mucosal blood flow was less than that in control animals that received hepatectomy alone. The suppression of 3H-thymidine uptake percentage and thymidine kinase activity after hepatectomy was more marked in animals treated with hepatectomy plus vagotomy than in controls treated with hepatectomy alone. Hepatic DNA level tended to be lower in animals treated with hepatectomy plus vagotomy than in controls. In animals treated with hepatectomy plus vagotomy, the peak level of the mitotic index was lower and the hepatic regeneration rate was evidently suppressed. These results suggest that it is not appropriate to apply vagotomy, during hepatectomy of cirrhotic livers, for the prevention of postoperative stress ulcer because it causes a marked reduction in gastric mucosal blood flow and suppresses hepatic regeneration.

Animals↗
PubMed1988

[Trans-arterial embolization or transarterial infusion of anti-cancer drugs suspended in a lipid contrast medium against unresectable metastatic liver cancer].

We had 84 patients with unresectable metastatic liver cancer from May, 1980 to December 1987 in the National Matsudo Hospital. Eighteen of them had no treatment; 26 of them had serial transarterial embolization (TAE) with or without infusion of anti-cancer drug dispersed in lipiodol; 7 of them had only serial trans-arterial infusion (L-TAI) of an anticancer drug suspended in lipiodol. A significant survival advantage of patients with TAE or L-TAI was noted when compared with no treatment, but there was no difference between the survival rate of patients with TAE and L-TAI. There were some 82 patients with unresectable metastatic liver cancer from October 1984 to March 1988 in Kyto Prefectural University of Medicine Hospital. Thirteen of them had L-TAI using one anti-cancer drug (one-drug group); 8 of them had L-TAI using two drugs (two-drug group); 22 of them had L-TAI with three drugs (three-drug group). The survival rate of the three-drug group was superior to the one- and two-drug groups. It was concluded that TAE was not necessary for metastatic liver cancer, but L-TAI must be undertaken, because combined cancer chemotherapy enhanced the effect of L-TAI.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

Merkel-neurite complexes in the fungiform papillae of two species of monkeys.

Merkel-neurite complexes in tongues of Japanese and cynomolgus monkeys were examined by means of light and electron microscopy. Merkel-neurite complexes were found preferentially in the epithelium of fungiform papillae located at the tip of the tongue. It appears that the anterior fungiform papillae of the monkey are highly adapted for both taste and mechanical sensation.

Animals↗
PubMed1987

Acquired von Willebrand disease due to inhibitor of human myeloma protein specific for von Willebrand factor.

A patient with acquired von Willebrand disease associated with multiple myeloma (IgG-lambda) is described. Mixture of his plasma or IgG fraction with washed control platelets resulted in the inhibition of aggregation with ristocetin, but mixture of control plasma or IgG fraction with washed patient platelets showed no inhibition of ristocetin-induced aggregation. Although his vWF: Ag, RCo, and factor VIII coagulant activity were all normal, inactivation of RCo was induced in normal plasma by incubation with patient plasma. Crossed immunoelectrophoretic analysis showed that vWF:Ag was composed of much more anodic component. A marked increase of Factor VIII and a rapid return of RCo to the baseline after 1-deamino-8-arginine vasopressin (DDAVP) infusion were observed. A transient increase in vWF:Ag after the infusion of DDAVP showed with less anodic forms and in the relative proportion as in normal. Treatment of the underlying disease also led to a correction of the bleeding time, improvement of platelet adhesion and ristocetin-induced aggregation, and normalization of crossed immunoelectrophoresis of vWF:Ag. The present study showed that myeloma-associated IgG interacted specifically with the antigenic sites on the von Willebrand portion of the Factor VIII complex.

Adult↗
PubMed1987

Characterization of the sppA gene coding for protease IV, a signal peptide peptidase of Escherichia coli.

The sppA gene codes for protease IV, a signal peptide peptidase of Escherichia coli. Using the gene cloned on a plasmid, we constructed an E. coli strain carrying the ampicillin resistance gene near the chromosomal sppA gene and an sppA deletion strain in which the deleted portion was replaced by the kanamycin resistance gene. Using these strains, we mapped the sppA gene at 38.5 min on the chromosome, the gene order being katE-xthA-sppA-pncA. Although digestion of the signal peptide that accumulated in the cell envelope fraction was considerably slower in the deletion mutant than in the sppA+ strain, it was still significant, suggesting the participation of another envelope protease(s) in signal peptide digestion.

Chromosome Deletion↗
PubMed1987

[Efficacy of vagotomy on liver regeneration in the prevention of stress ulcer after partial hepatectomy in the cirrhotic rat].

Possible effects of vagotomy (a means of preventing stress ulcers after partial hepatectomy in cirrhotic liver) on liver regeneration were explored. Cirrhosis was induced in rats by means of intraperitoneally administering 4% thioacetamide for 10 consecutive weeks. These rats were subjected to partial hepatectomy (ca. 68% resection) and vagotomy at the same time. Normal rats of consistent age served as controls after receiving hepatectomy. In controls, which received hepatectomy alone, both gastric pH and gastric wall blood flow showed a significant reduction on the third day after surgery. In animals which received both hepatectomy and vagotomy, postoperative reduction in gastric pH was suppressed, but postoperative reduction in gastric wall blood flow was more marked compared to those of controls. In animals which received both hepatectomy and vagotomy, postoperative 3H-thymidine intake and thymidine kinase activity were markedly suppressed compared to controls. In animals which received both hepatectomy and vagotomy, the peak level of mitotic index and the hepatic regeneration rate were markedly suppressed compared to those of controls. The above results indicate that vagotomy is not advantageous to liver regeneration and prevention of stress ulcer after partial hepatectomy in cirrhotic rat because of its potency of inducing marked reduction in gastric wall blood flow and impediment of liver regeneration.

Animals↗
PubMed1987

[Experimental study on mechanism of onset of acute ulcer viewed from blood coagulation and activities of fibrinolysis after hepatectomy in liver cirrhosis].

Using liver cirrhosis rats induced by intraperitoneal administration of 4% thioacetamide (TAA) consecutively for 10 weeks, the authors made a study on the activities of blood coagulation and fibrinolysis in the onset of acute ulcer after hepatectomy. The results were as follows: 1. On the 3rd day after hepatectomy increase in the portal blood pressure, approximate 30% decrease in gastric wall blood flow and increase in fibrinolysis in blood and gastric mucosa were observed. While no bleeding was recognized, edema and hyperemia were noticeable. 2. On the 3rd postoperative day when the maximum increase of fibrinolysis in blood and gastric mucosa was observed water immersion restraint stress was loade. Two hours after loading, fibrinolysis in blood and tissue increased further, and in accordance with it, bleeding and erosion were seen to a high degree in gastric mucosa. On the other hand, in the EACA group, in which anti-fibrinolytic agent, epsilon-amino carpic acid was administered, the increase was moderate in the fibrinolysis in blood and mucosa after loading the stress. Though bleeding and development of erosion were not completely controlled, values of fibriolytic activity of the tissue in the EACA group were lower than those of control group.

Acute Disease↗