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Biomedical subjects

A Horie

Publications and source records attributed to A Horie.

At least 91 records · Page 5Linked to original sources
PubMed1985

Adult T-cell leukemia complicated by hypercalcemia. Report of three autopsy cases with special reference to the etiologic factor of hypercalcemia.

Three autopsy cases of adult T-cell leukemia (ATL) complicated by a severe hypercalcemia are presented. In two of them, the hypercalcemia itself was the direct cause of death. There was no evidence of an increase of serum PTH in all three cases. Prostaglandins were within normal range in two of them. By a bioassay, a bone-resorbing factor, osteoclast activating factor (OAF)-like substance, was demonstrated in the culture medium of leukemic cells from one patient. Also, various degrees of osteoclastic activation were found in the bones of all three patients by the postmortem examination. It may be that the hypercalcemia occurring in cases of ATL is partly caused by the humoral factor, which is released from leukemic cells and activates a bone resorption by osteoclasts. Similar cases in which a significant activation of osteoclasts was practically demonstrated by histopathologic examination in addition to the detection of a bone-resorbing factor have been rarely reported.

Adult↗
PubMed1985

[Clinicopathological examination of 12 autopsy cases of carcinomatosis of the bone marrow].

Twelve autopsy cases of carcinomatosis of the bone marrow were examined clinicopathologically. Among them, 7 were gastric adenocarcinoma, and the other 5 were a rectal carcinoid and carcinomas of the lung, prostate, maxilla and kidney, respectively. The gastric cancers were almost all poorly differentiated adenocarcinoma with mucin production and presented poorer prognoses than the other cancers. Leukoerythroblastic anemia, microangiopathic hemolytic anemia and DIC were found more frequently in the gastric cancers than in the others. It is concluded that the evolution of these critical hematologic disorders may be dependent on differences of histologic type, original focus and cancer-host interactions as well as wide-spread skeletal metastases of cancer cells.

Adult↗
PubMed1985

Pruritus and mast cell proliferation of the skin in end stage renal failure.

We studied the relationships between dermal mast cell proliferation and pruritus or hyperparathyroidism in hemodialysis (HD). Skin biopsies were taken from 59 patients in end stage renal failure; 51 were on maintenance HD, and the other 8 were not. As a control, 34 non-renal failure pruritic patients were used. Thirty-one of the 59 end stage renal failure patients (52.5%) had pruritus. The incidences of pruritus found in patients on HD and those not on HD were 56.9% and 25%, respectively. Significantly larger numbers of dermal mast cells were found in HD patients than in the control. There was no clear relationship between dermal mast cell proliferation and serum parathyroid hormone (PTH) levels. We speculated that the cause of pruritus in the patients undergoing maintenance HD was due to an increase of dermal mast cells and a release of histamine as a result of extra-corporeal circulation.

Adult↗
PubMed1984

Relation of fine structure to prognosis for papillary adenocarcinoma of the lung.

Eight cases of papillary adenocarcinoma of the lung were investigated by light and electron microscopy. Prognoses for all but one patient were favorable. Two patients (husband and wife) who underwent tumor resection during the same year experienced no disease-related problems for more than seven years afterward. Microscopic study of the papillary adenocarcinomas revealed columnar, peg-shaped, mucus-secreting tumor cells lining the alveoli. The tumor tissue contained alveolar macrophages, with some multinucleated giant cells, interstitial lymphoid infiltrates, mildly thickened alveolar walls, and a few pneumoconiotic foci. These inflammatory stromal reactions in the tumor tissue might have been associated with the favorable prognoses. Nuclear inclusions were detected in some tumor cells in all cases. Ultrastructurally, the inclusions contained tubular, granular, crystalline, and electron-dense homogeneous structures in addition to unclassifiable nuclear bodies. The tubular structures were in close proximity to inner leaflets of the nuclear membranes. The papillary adenocarcinoma cells had features of totipotential bronchioloalveolar cells, differentiating toward type II pneumocytes, Clara cells, and ciliated epithelial cells.

Adenocarcinoma↗
PubMed1984

Malignant lymphoma of the parotid gland with monoclonal cytoplasmic immunoglobulin.

A 56-year-old Japanese man with a malignant lymphoma of the parotid gland was reported. The tumor was located in the superficial lobe of the parotid gland, and somewhat invaded the surrounding soft tissues, but the regional lymph nodes were not involved. Histologically, the tumor was composed of round cells with plasmacytoid configurations and small lymphocytes. The plasmacytoid cells showed eccentric nuclei with fairly marked irregularities and perinuclearr halos. In a large number of tumor cells, a monoclonal cytoplasmic immunoglobulin (CIg), IgG-Kappa type, was demonstrated by the PAP method. Ultrastructurally, some of the tumor cells showed well-developed endoplasmic reticulum. From these findings, this tumor was diagnosed as a diffuse B-cell lymphoma, mainly composed of lymphoplasmacytoid cells. And this tumor may bear a similar nature to an extramedullary plasmacytoma of the classical terminology. Malignant lymphoma of the parotid gland is rare but a case with the demonstration of monoclonal CIg is considered very rare.

Female↗
PubMed1984

Histopathological features and their association with steroid receptors in women with breast cancer in Fukuoka, Japan.

In Fukuoka, Japan, infiltrating duct carcinoma predominated among 213 breast cancer cases, age 45 to 74. Lobular and medullary carcinomas were infrequent. About thirty three percent of the women had marked productive fibrosis, based on the UICC code type. Both rough margin and productive fibrosis of the cancer increased with age of the patients. On the contrary, most of accompanying hyperplastic lesions decreased with age. The difference was significant for cystic formation between 10-year age groups of 45-54 and 55-64 (chi 2 = 6.61, p less than 0.02). Hormone receptors of 115 of the cases were independently measured and characterized according to histologic patterns manifesting host reaction (stromal cell infiltration and lymph node histiocytosis). Positive estrogen receptors were more frequent among ductal carcinomas with slight or no cellular reaction than those with extensive cellular reaction. The same pattern was also present for progesterone and androgen receptors. The extent of sinus histiocytosis in lymph nodes without metastasis was also inversely correlated with the presence of these hormone receptors. The correlation was significant for androgen receptor (chi 2 = 5.31, p less than 0.05). Positive estrogen receptor was more common among ductal carcinomas with prominent fibrosis than among those with minimal fibrosis.

Aged↗
PubMed1984

Leiomyomatosis in the pelvic lymph node and peritoneum.

This paper is concerned with a rare clinical entity, i.e. leiomyomatosis of pelvic promontory lymph node in a 50-year-old Japanese woman and leiomyomatosis peritonealis disseminata in a 41-year-old one. Despite such daughter nodules, all of the leiomyomas showed benign histological features. Morphogenesis of the discontinuous leiomyomas was discussed in relation to pelvic endometriosis. Because of a favorable prognosis in the leiomyomatosis, no more aggressive therapy than that necessary to extirpate the tumor is recommended.

Adult↗
PubMed1984

Malignant mesenchymoma of the esophagus.

This is a case report of a malignant mesenchymoma of the esophagus in a 50-year-old Japanese man. The tumor was a sessile polypoid mass showing a downward invasion limited to the submucosa of the esophagus. Histologically, the lesion contained rhabdomyosarcomatous and osteosarcomatous areas, in addition to an ill-defined fibrosarcomatous element. In contrast with reports of carcinosarcoma up to the present, this tumor lacked any invasive lesion of an epithelial malignancy. The morphogenesis of these tumor groups was discussed from a hamartoblastomatous standpoint.

Esophageal Neoplasms↗
PubMed1984

Amyloid angiopathy and lobar cerebral haemorrhage.

Seven cases of lobar cerebral haemorrhage due to amyloid angiopathy were found among 60 necropsy cases of intracerebral haemorrhage. Clinically five patients were demented and two had hypertension. Immediately after the onset of stroke there was a high incidence of headache and vomiting, followed by nuchal rigidity. Amyloid angiopathy was most prominent in the cerebral cortex and the leptomeninges. Senile plaques were noted in all cases. One should suspect that a haemorrhage may be due to amyloid angiopathy, when lobar cerebral haemorrhage occurs in an aged, normotensive patient with or without dementia. Surgical evacuation of the haematoma is inadvisable, because of the diffuse nature of amyloid angiopathy, high recurrence rate and less tendency to cause brain stem compression.

Aged↗
PubMed1984

Meningioma of the parapharyngeal space: a unique extension of intracranial tumor.

A 45-year-old woman with a meningioma growing in the parapharyngeal space is reported. Her initial symptom was a stuffy feeling in the right ear and swelling of the right parapharynx. The parapharyngeal mass was biopsied, and a frozen section diagnosis suggested a paraganglioma. On electron microscopy, however, the tumor cells failed to show secretory granules, and represented a prominent interdigitation of the cytoplasm with occasional desmosomal attachments. Based on these features the tumor was diagnosed as a meningioma. Thereafter a mass lesion in the temporal lobe of the brain was detected by computerized tomography of the brain. The extracranial extension of the meningioma may occur in some occasions, but such cases in which the infiltrative portion in the parapharyngeal space was initially discovered have been rarely reported.

Diagnosis, Differential↗
PubMed1983

Immunohistological analysis of surfactant-apoprotein in the bronchiolo-alveolar carcinoma.

Fifty-five cases of bronchiolo-alveolar carcinoma were examined immunohistochemically using mono-specific antisurfactant apoprotein IgG obtained from a rabbit immunized with monkey surfactant preparations. Formalin-fixed and paraffin-embedded lung tissues were stained by an immunoperoxidase method. Antibody stained the normal and hyperplastic alveolar type II pneumocytes, but did not stain bronchial epithelium or other lung cells. In tumor tissue, 26 (47.3%) of 55 cases were positively stained in the cytoplasm, and 15 showed reaction products in both the cytoplasm and intranuclear regions. By electron microscopy osmiophilic lamellar bodies and microvilli on the free surface, thought to be characteristic of type II pneumocytes, were seen in tumor cells (2 cases). In the five cases, the nuclei contained branching tubular inclusions. The results of this study support the idea that certain bronchiolo-alveolar carcinomas originate from type II pneumocytes, the intranuclear inclusions may represent an abnormal proliferation of nuclear membranes containing surfactant-apoprotein.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1983

Malignant chemodectoma (paraganglioma) of the larynx. A case report with electron microscopy and biochemical assay.

This reports presents a case of malignant chemodectoma in the epiglottic region of a 47-year-old man. His initial complaint was laryngeal discomfort and he expired from generalized metastases of the tumor about one year after operation. The tumor was detected by laryngoscopy and laryngogram. The yellow parenchymatous tumor, 2.8 x 2.5 x 1.5 cm in size, was resected together with two enlarged regional lymph nodes. The mass was subjected to a histopathological study and biochemical assay. Microscopically, the tumor was located in the submucosa of the epiglottis and showed an alveolar growth pattern of comparatively uniform tumor cells. Neurosecretory granules were clearly demonstrated by Grimelius' method and by electron microscopy. The biochemical assay revealed that the tumor contained small amounts of serotonin, epinephrine, norepinephrine, and dopamine. The distribution of paraganglia as the source of these tumors, the clinicopathological review of the previous reports and significance of neurosecretory granules are discussed.

Cytoplasmic Granules↗
PubMed1983

[Cancer of the intra-pancreatic common bile duct observed 9 years after choledochojejunostomy].

A 54-year-old female was admitted in June 1982, complaining of jaundice and fever of several months' duration. She had undergone cholecystectomy and choledocho-jejunostomy, 22 years and 9 years before, respectively. On admission, PTCD was carried out immediately. It showed marked dilatation, of the common bile duct and stricture of the anastomosed portion. On August 2, she died of jaundice and sepsis. On autopsy, a cystic tumor was found at the common bile duct remnant in the head of the pancreas. It was a tubular adenocarcinoma and invaded the ostium of the choledochojejunostomy. The occurrence of adenocarcinoma may be one of the late complications of choledochojejunostomy.

Adenocarcinoma↗
PubMed1983

[An autopsy case of maxillary cancer representing carcinomatosis of the bone].

A 51-year-old man was admitted to our Otorhinolaryngological Clinic on November 18, 1980, complaining of a nasal blockage. A biopsy specimen from the left maxillary sinus resulted in a diagnosis of poorly differentiated squamous cell carcinoma. About a year after left maxillectomy, he presented with widespread skeletal metastasis and severe anemia. On August 25, 1982, he died of pneumonia. On autopsy, generalized bone metastasis was found; there was no local recurrence and only minimal pulmonary metastasis. Although there are some maxillary cancer cases with restricted bone metastasis, diffuse carcinomatosis of the bone, as seen in this case, is rare. We also present a review of similar cases.

Bone Neoplasms↗
PubMed1981

Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis of patients.

Epon embedded sections of large cell carcinoma of the lung obtained from 26 patients were examined by light and electron microscopy. On an ultrastructural basis this carcinoma was subclassified into four types: squamous, adenosquamous, adenocarcinomatous, and giant cell types. The giant cell carcinoma was regarded as a special type of squamous or undifferentiated carcinoma. Transition between each of these types was clearly demonstrated. Follow-up study revealed that a close correlation existed between these types and the prognosis of the patients, the squamous type showing a better prognosis and the adenosquamous and adenocarcinomatous types exhibiting equally poor prognoses. The giant cell type invariably pursued a fulminant course. It was suggested that each of the types might represent different stages and directions of differentiation of cancer cells originating from the same ancestry. The authors' view favors the Y construct theory concerning the histogenetic pedigree of pulmonary carcinoma.

Adenocarcinoma↗