Search PubMed⌕ Search

Biomedical subjects

A Hoffmann

Publications and source records attributed to A Hoffmann.

At least 379 records · Page 21Linked to original sources
PubMed1988

Platelet aggregation, lipids and excretion of catecholamines after acute physical exercise in patients with myocardial infarction.

The effect of acute physical exercise and a four-month conditioning program on cardiovascular risk factors was investigated in patients with myocardial infarction. The bicycle exercise testing caused a moderate rise in urinary epinephrine, serum cholesterol and HDL cholesterol levels. The changes in platelet aggregation and urinary catecholamines were markedly greater in the group with exercise induced ischaemic changes. Under the effect of the conditioning program a significant improvement in the performance capacity and circulatory response could be observed. The direction of changes in platelet aggregation and in the lipid parameters were favourable too.

Catecholamines↗
PubMed1988

Heart valve replacement with St. Jude Medical valve prosthesis. Long-term experience in 743 patients in Switzerland.

Between November 1978 and June 1986, 828 St. Jude Medical valves were implanted in 743 patients whose mean age was 57 years (range, 1-83 years) and who had been admitted to the University Hospitals in Basel, Berne, and Lausanne, Switzerland. Aortic valve replacement was performed in 456 patients, mitral valve replacement in 200, tricuspid valve replacement in six, double valve replacement in 77, and triple valve replacement in four. In 187 patients, additional surgical interventions were performed. Operative mortality was 1.6%, and the 4-week postoperative mortality was 4.0%. During a mean follow-up period of 2.6 years, the annual mortality rate was 3.1%, and the annual cardiac mortality rate was 2.1%. The thromboembolic rate per 100 patient-years was 1.3 after aortic valve replacement, 3.0 after mitral valve replacement, and 1.0 after multiple valve replacement. The incidence of major bleeding was 1.3 per 100 patient-years. Valve dysfunction attributable to thrombotic obstruction occurred in three patients, and that attributable to leaflet dislocation in one (annual dysfunction rate, 0.2%). Twelve patients developed infectious endocarditis, six of whom died. However, in four patients, reoperation and, in two patients, antibiotic treatment alone were successful in treating the infection. A paravalvular leak necessitating reoperation developed in 10 patients. In three patients, the leak was caused by infectious endocarditis. Reoperation had no operative mortality. In three patients (0.4%), a mild hemolytic anemia was found.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

Stereochemistry of the methylmalonyl-CoA decarboxylation reaction.

The steric course of the decarboxylation of (S)-methylmalonyl-CoA to propionyl-CoA, catalyzed by the biotin-dependent sodium pump methylmalonyl-CoA decarboxylase of Veillonella alcalescens was determined. The decarboxylation of (S)-methylmalonyl-CoA in 3H2O yielded (R)-[2-3H]propionyl-CoA; and the decarboxylation of (S)-[2-3H]methylmalonyl-CoA in H2O produced (S)-[2-3H]propionyl-CoA. The results demonstrate retention of configuration during the decarboxylation reaction. The substrate stereochemistry of methylmalonyl-CoA decarboxylase is thus the same as that of all other biotin-containing enzymes investigated.

Acyl Coenzyme A↗
PubMed1987

Effect of amiodarone on sinus node function in patients with sick sinus syndrome.

The effect of amiodarone on sinus node function has been studied in 9 patients with symptomatic sick sinus node as documented by Holter-ECG. All patients had programmable dual-chamber pacemakers. Sinus node activity was assessed by intermittently inhibiting the pacemakers before and after four weeks of oral amiodarone treatment. Sinus node function was not altered by amiodarone in 5 patients but was severely depressed in 4 patients. Thus, it is concluded that amiodarone cannot be used safely in all patients with the tachybrady syndrome for the treatment of symptomatic tachyarrhythmias without concomitant pacing.

Aged↗
PubMed1987

[Doppler sonography in cardiologic diagnosis].

Ultrasonic Doppler analysis of intracardiac blood flow is a technique complementary to echocardiographic imaging, and an important tool in non-invasive diagnosis. Doppler ultrasonography enables the evaluation of systolic murmurs, particularly the calculation of pressure gradients and valve areas in stenotic lesions. In patients with aortic stenosis, there was a very close correlation of invasive and non-invasive pressure gradients (r = 0.92). In patients with mitral stenosis, invasive and non-invasive valve areas were correlated as well (r = 0.78). In addition, regurgitant and shunting jets can easily be traced and assessed at least semi-quantitatively by using 2D-colour flow mapping, or 2D-duplex scanning. Doppler echocardiography is a prime aid in the evaluation of children and young adults, in whom cardiac catheterisation can often be omitted because there is no need for coronary arteriography. It is also an important tool in the follow-up of patients with cardiac valve prostheses, in particular bioprostheses. A time-dependent reduction of valve areas was noted in patients with aortic bioprostheses (r = -0.80).

Aortic Valve Insufficiency↗
PubMed1987

The effect of training on the physical working capacity of MI patients with left ventricular dysfunction.

Exercise performance in 41 men with impaired left ventricular function following an acute myocardial infarction was studied. Twenty (intervention group) subsequently underwent a 4-month supervised exercise training programme in an outpatient capacity, with three sessions per week. On completion, exercise performance was compared to the 21 control patients who received conventional rehabilitation. Initial tests showed no difference between the two groups. At the end of the programme significant improvement was found in all the investigated parameters in the intervention group. Supervised training had a beneficial effect on the physical working capacity of the patients with left ventricular dysfunction and no complications arose.

Adult↗
PubMed1987

Release of plasminogen activator by batroxobin.

In the isolated perfused pig ear, batroxobin caused a dose-dependent increase in the release of plasminogen activator. The activator-releasing effect required the presence of the active enzyme. The activator released was of the tissue-type.

Animals↗
PubMed1987

[Release of plasminogen activator by SIN-1].

SIN-1--a pharmacologically active metabolite of the vasodilating agent molsidomine--caused an increase in plasminogen activator release of about 50 per cent at a final concentration of 10(-7) mol/l on perfusion of isolated pig ears. An increase in SIN-1 concentration did not produce a further increase in activator release. The released activator is of the tissue-type. After repeated perfusion of the isolated pig ear with SIN-1 no further significant increase in plasminogen activator release occurred.

Animals↗
PubMed1987

[Elimination of caffeine and metamizole in the menstrual cycle of the fertile female].

The elimination of caffeine from serum and that of the main metabolites of metamizol in serum were investigated in 9 healthy women on days 1, 8, 14 and 21 of the menstrual cycle. In the luteal phase, when the progesterone level is highest and the estradiol concentration is high as well, the elimination of caffeine is about 25% longer than in the follicular phase. In contrast to caffeine, the metabolism of metamizol is slightly accelerated if the endogenous hormone level is high. The present results suggest that endogenous hormones have different effects on biotransformation activities. These results are without practical consequences yet.

Adult↗
PubMed1986

Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis.

Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clinically uninvolved skin in psoriasis (autologous mixed epidermal cell lymphocyte reaction, AMECLR). Age- and sex-matched individuals served as controls. We found that the AMLR in psoriasis (n = 11) was similar to that in healthy controls (n = 16); furthermore, cell proliferation was alike in the presence of either 5% AB-serum or autologous serum. By contrast, while the AMECLR in healthy controls (n = 9) resembled that in psoriatics employing epidermal cells from univolved skin, epidermal cells from lesional sites (n = 10) induced a significantly higher proliferation of autologous T cells in the AMECLR (P less than 0.01). We conclude that the in vitro stimulation of T cells by non-T mononuclear leukocytes is normal in psoriasis and is not regulated by autologous serum. Lesional psoriatic epidermal cells, however, are more active in stimulating autologous T cell proliferation than cells from univolved psoriatic or normal epidermis.

Adult↗