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Biomedical subjects

A Hjortrup

Publications and source records attributed to A Hjortrup.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Liver transplantation in Denmark. First-year experiences].

During the first 12 months of the Danish Liver Transplantation program, which began in October 1990, 21 transplantations were performed in 11 women, six men and three children. One patient required a retransplant. Fourteen operations were performed electively and six patients were transplanted for acute and subacute fulminant liver failure and coma, two patients had reduced size livers because of large donor liver. There were no peroperative deaths. One of the elective patients died after three weeks from multiorgan failure and sepsis. Two of the emergency patients died after 20 and 22 days. One from graft dysfunction due to stenosis of the celiac trunk and the other of exudative pericarditis. One patient died from chronic rejection and CMV-infection after seven months. Complications were relatively few and acute rejection occurred in 40% of the patients. Fifteen patients are discharged with normal liver function and 11 of these were back at work, school or previous functions in the home. It is concluded that these results are comparable to the best results from other centres but that 21 transplants in 12 months must be a minimum activity.

Adolescent↗
PubMed1993

[Partial orthotopic liver transplantation].

From October 1990 to May 1992, nine of 38 patients with liver transplants (24%) had partial orthotopic liver transplantation on account of lack of size-matching donor livers. The preliminary results have presented very few problems; there was no per- or postoperative mortality and no surgical complications. Four patients had episodes of acute rejection which responded to anti-rejection therapy, and two patients were treated for CMV infection. All patients are discharged with normal liver function 4-9 weeks after transplantation (median 5 weeks). The method seems to be safe and can be used in centers with limited activity, where there is a problem of having the correct liver at the correct time.

Adolescent↗
PubMed1993

Complications after J-pouch ileoanal anastomosis: stapled compared with handsewn anastomosis.

OBJECTIVE: To compare the morbidity after stapled compared with handsewn J-pouch ileoanal anastomoses. DESIGN: Retrospective study. SETTING: University Hospital, Copenhagen, Denmark. SUBJECTS: 144 consecutive patients who underwent either handsewn or stapled J-pouch ileoanal anastomosis between November 1983 and December 1991. MAIN OUTCOME MEASURES: Length of operation; operative blood loss; incidence of anastomotic breakdown, fistula and stenosis; and number of pouches that were excised as a result of complications. RESULTS: Ninety-six patients had handsewn, and 48 patients had stapled, anastomoses. There were no differences between the groups except in the length of operation (median (range) 270 (155-420) in the handsewn group compared with 197 (135-300) in the stapled group, p < 0.001), and the incidence of later stenosis of the anastomosis (22/96, 23%, compared with 3/48, 6%, p = 0.02). Patients who developed anastomotic breakdown lost significantly more blood during operation (median 2300 ml, range 1100-7500, compared with 1600 ml, range 600-6000, p = 0.02), and women were more likely to develop anastomotic leaks than men (15/70 compared with 3/74, p = 0.009). CONCLUSION: We conclude that so far the stapled anastomoses have given superior results, but it remains to be seen whether other differences will emerge as length of follow up increases.

Adolescent↗
PubMed1991

Fibrin adhesive in the treatment of perineal fistulas.

Fifteen patients who developed a persistent perineal sinus after excision of the rectum and eight patients with a perineal fistula appearing after treatment of perineal abscesses were treated with instillation of fibrin adhesive to close the sinus or fistula. In 12 patients, the sinus tracts or fistulas were completely and permanently closed (52 percent). In five patients (22 percent), the fistulas healed after two or three attempts, while, in six patients (26 percent), the method failed to provide lasting closure. The method seems to be a valuable alternative in the treatment of a persistent, long and narrow perineal sinus or fistula.

Administration, Topical↗
PubMed1990

Effect of major surgery on absorption rate of NPH insulin injected s.c.

The absorption rate of NPH insulin injected s.c. was evaluated before operation and on the day of surgery by continuous measurements of residual radioactivity of 125I-labelled insulin in 10 patients undergoing major abdominal surgery. The results show that major surgery has no effect on rate of absorption of intermediate acting insulin.

Abdomen↗
PubMed1990

Antibiotic prophylaxis in surgery for hip fractures.

Totally, 185 patients, operated on for a fresh hip fracture, were randomly allocated to either methicillin antibiotic prophylaxis or no prophylaxis and followed for 1 month. Two superficial wound infections were recorded in the prophylaxis group and one in the control group. Prophylactic use of antibiotics in surgery for hip fractures seems unnecessary provided strict aseptic routines in the operating room are followed.

Adult↗
PubMed1989

[Cimetidine treatment of stomach cancer].

The effect of cimetidine treatment in cancer of the stomach was investigated in a double-blind, multicentre study comprising eight departments in Greater Copenhagen. Immediately after operation (or the decision not to operate) 181 patients were subdivided at random to treatment with a placebo or cimetidine in a dosage of 400 mg twice daily for two years or until death. Compliance control was carried out every third month. The mean survival in the cimetidine group (450 days, 1-1,826) was significantly longer (p = 0.02) than in the placebo group (316 days, 1-1,653).

Adult↗
PubMed1989

Two daily doses of sucralfate or cimetidine in the healing of gastric ulcer. A comparative randomized study.

A double-blind, randomized study compared the healing of gastric ulcer during a twice-daily regimen of 2 g sucralfate or 400 mg cimetidine. The patients received the tablets one-half hour before breakfast and one-half hour before bedtime. The study included 76 patients with endoscopically proven gastric ulcer. Patients with ulcers less than 3 cm from the pyloric ring and patients with ulcers less than 3 mm in diameter were excluded from the study. Sixty-four patients completed the study. Healing was endoscopically assessed at four-week intervals for 12 weeks. After four, eight, and 12 weeks, the healing rates for cimetidine were 55, 81, and 94 percent, respectively; the healing rates for sucralfate were 52, 79, and 91 percent, respectively. No statistically significant difference was found between the two regimens. At 12 weeks, the risk of overlooking a difference in favor of one of the two dosage regimens was less than 20 percent. The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 400 mg cimetidine twice daily.

Adult↗
PubMed1989

[Long-term results of ileorectal anastomosis in the treatment of ulcerative colitis].

During the period 1951 to 1987, ileorectal anastomosis in one or two seances, depending upon the activity of the disease, was carried out in 63 patients with ulcerative pancolitis. It is concluded that the operative procedure seen in relation to recent continence-retaining types of operation and despite the relatively great frequency of convertion of 20% will still constitute an alternative in surgical treatment of patients with ulcerative colitis.

Colitis, Ulcerative↗
PubMed1989

Intraincisional antibiotic in addition to systemic antibiotic treatment fails to reduce wound infection rates in contaminated abdominal surgery. A controlled clinical trial.

One hundred ninety patients with peritonitis at the time of abdominal surgery were allocated at random to systemic antibiotic treatment alone or systemic antibiotic treatment combined with topical application of antibiotics in the wound at the time of wound closure. The overall wound infection rate was 17 percent without significant difference between the two treatment groups (P greater than 0.80).

Abdomen↗
PubMed1989

Rectal anastomosis with application of luminal fibrin adhesive in the rectum of dogs. An experimental study.

By performing a colorectal anastomosis, the risk of a serious clinical leakage is about 10 percent. On the basis of this, the current study described a combined fibrin adhesive-sutured anastomosis in the rectum performed with interrupted seromuscular sutures externally and fibrin adhesive in the mucosa-mucosa cleft internally. Ten dogs having combined anastomosis were compared with ten dogs having a two-layer sutured anastomosis in the rectum as a control. The median bursting strength in the rectum seven days after the operation was 280 mm Hg (range, 180 to 340 mm Hg) for the combined anastomosis and 260 mm Hg (range, 170 to 405 mm Hg) for the sutured anastomosis in the control group. Two anastomoses with two-layer sutured anastomosis had a leak demonstrated radiographically, while no leakage was demonstrated in the ten dogs with combined anastomosis. In conclusion, intraluminal applied fibrin adhesive may contribute to the security of the sutured rectum-anastomosis.

Anastomosis, Surgical↗
PubMed1989

Randomized trial of fibrin adhesive for reduction of drained secretion after elective cholecystectomy.

Eighty patients scheduled for elective cholecystectomy were randomly allocated to application of fibrin adhesive (Beriplast) to the gallbladder bed or to a control group. No significant difference was found between the two groups in regard to amount of postoperatively drained secretion or in drainage time. Fibrin adhesive thus had no effect on secretion of peritoneal fluid after simple cholecystectomy.

Adult↗
PubMed1989

Healing of the fibrin adhesive anastomosis in the small intestine of pigs.

The healing of the fibrin adhesive small intestinal anastomosis from 1/2 to 168 hours postoperatively was evaluated by the bursting strength method in 28 pigs. There were no clinical leaks. After an initial increase in strength, from 1/2 to 48 hours postoperatively, the strength of the anastomosis dropped to a low at 96 hours postoperatively. From then on, a steady increase in strength was observed. A similar pattern of healing has been observed for the sutured intestinal anastomosis.

Animals↗
PubMed1988

Effect of cimetidine on survival after gastric cancer.

The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.

Actuarial Analysis↗