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Biomedical subjects

A Hashimoto

Publications and source records attributed to A Hashimoto.

At least 397 records · Page 22Linked to original sources
PubMed1987

A comparative analysis of left ventriculography and root aortography for estimating aortic annular size.

This study was undertaken to compare the usefulness of left ventriculography versus root aortography as a means of assessing the aortic annular size in 75 patients with a narrow aortic anulus. These patients were divided into two groups: Group I consisted of 57 patients undergoing standard aortic valve replacement with a 21 mm prosthesis and Group II consisted of 18 patients undergoing modified aortic valve replacement with the aid of an anulus-enlarging procedure or an apico-aortic conduit. In Group I, left ventriculography gave 23.2 +/- 1.8 mm (mean +/- standard deviation), whereas the aortography method showed 22.4 +/- 2.7 mm (p less than 0.05). Those values of 20 mm or less were regarded as imperfect measurements; inaccurate results were more frequent in the aortography method (16 cases; 28%) than in the left ventriculography method (only two cases; 3.5%), with significant difference (p less than 0.025%). In Group II, there was no significant difference in respective values determined by the two different methods; 18.7 +/- 3.0 mm, with a range from 13 to 23 mm in the left ventriculography method, and 19.9 +/- 3.1 mm, with a range from 14 to 24 mm, in the aortography method (p greater than 0.2). Imperfect measurement by the aortography method tended to occur when the cusp base was severely deformed. The results indicated that left ventriculography was more reliable than root aortography for estimating the size of the aortic anulus.

Adolescent↗
PubMed1986

Apomorphine has a therapeutic effect on neglect produced by unilateral dorsomedial prefrontal cortex lesions in rats.

Neglect is a disorder in which the response to stimulation is diminished or absent on the side of the body contralateral to the lesion in the absence of an elemental sensory or motor defect. Most cases of neglect in humans are induced by cortical damage, but there have been no investigations of the pharmacologic basis of neglect induced by cortical damage. We examined the role of the dopamine system in polymodal neglect caused by a unilateral lesion of the medial precentral prefrontal cortex of the rat. A dose-response examination of the effect of apomorphine on neglect revealed that apomorphine, at 0.5 mg/kg, the highest dose examined, significantly improved the orientation scores of subjects in all modalities tested and significantly decreased the total number of allesthetic responses. The therapeutic effect of apomorphine was mediated by dopamine receptors as the therapeutic effect of apomorphine was blocked by prior administration of spiroperidol. These results demonstrate the important role of disruption of dopamine mechanisms in neglect induced by a lesion of medial precentral cortex.

Animals↗
PubMed1986

Present status of thromboembolic complications in patients with prosthetic heart valves.

When the incidence of thromboembolism (TE) as a complication was investigated in 171 patients with prosthetic heart valves using pyrolytic carbon, 10 cases were identified in a mean follow-up period of 2.43 years. Of these 10, two patients had died. The incidence of TE as a percentage per patient--year was 2.41 on the whole, 2.15 in patients with aortic valve replacement (AVR), 2.48 in patients with mitral valve replacement (MVR) and 2.52 in patients with double valve replacement (DVR). It is evident that TE is still an important complication following prosthetic heart valve surgery and the patient's return to society. TE tended to occur somewhat more often in cases of MVR and DVR than in those of AVR. TE was apt to appear early in the postoperative period, often within a year, and was often seen in the brain. To prevent TE, it is necessary to carefully control blood coagulation by the administration of anticoagulants.

Adult↗
PubMed1986

Heterogeneity of anterior pituitary cell antibodies detected in insulin-dependent diabetes mellitus and adrenocorticotropic hormone deficiency.

A sensitive assay method for pituitary cell antibodies (PitCA) was established by a biotin/avidin system using rat pituitary. Results in 24 cases out of 81 insulin-dependent diabetic patients and 10 cases of 21 adrenocorticotropic hormone (ACTH) deficient patients were positive for autoantibodies to anterior pituitary cell cytoplasm. PitCA observed in the sera of insulin-dependent diabetic patients were suspected of being pituitary specific and independent with islet cell antibodies (ICA) and islet cell surface antibodies (ICSA). In the sera of ACTH deficient patients, PitCA were frequently absorbed with liver acetone powder. Populations of insulin-dependent diabetes mellitus (IDDM) are almost equal in males and females. A total of 16 cases out of 21 ACTH deficient patients were female. These results suggest that heterogenous PitCA are involved in the sera of those patients with IDDM and ACTH deficiency.

Adrenocorticotropic Hormone↗