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Biomedical subjects

A Gupta

Publications and source records attributed to A Gupta.

At least 883 records · Page 49Linked to original sources
PubMed1986

Modulation of benzene toxicity by an interferon inducer (6MFA).

Repeated intraperitoneal administration of benzene (1.0 ml/kg body wt) for 3 days produced leucopenia, lymphocytopenia and an increased number of nucleated cells in the bone marrow and significantly decreased organ weights of thymus (P less than 0.001) and spleen (P less than 0.001) in female albino rats. Iron content, lipid peroxidation and superoxide dismutase activity of the liver and bone marrow were significantly increased as a result of benzene exposure. Prior administration of 6MFA, an interferon inducer with immunomodulating potential, was found to ameliorate some of the adverse effects of benzene as well as restoration of hepatic architecture histologically. Lipid peroxidation and iron content were both normalised, whereas superoxide dismutase activity was further increased and the number of lymphocytes and bone marrow cells returned to normal. Pretreatment of animals with 6MFA was able to enhance the SRBC antibody titre in benzene-treated immunosuppressed animals. The beneficial effects of 6MFA in the amelioration of the acute toxicity of benzene therefore assume certain significance.

Animals↗
PubMed1986

Tuberculosis and renal transplantation--observations from an endemic area of tuberculosis.

Ninety-five renal transplant recipients from an endemic area of tuberculosis were investigated to find out the prevalence and course of tuberculosis in pre- and post-transplant periods. Eleven patients had tuberculosis in the pre-transplant period - pulmonary (2), pleural (2), miliary (1), abdominal (2), lymph node (5) and pericardial (1). They were transplanted after antituberculous therapy of 3 to 6 months with satisfactory results. The anti-tuberculous treatment was usually continued for 2 years. Only one of the above 11 patients had evidence of tuberculosis in the post-transplant period. Nine patients developed tuberculosis for the first time in the post-transplant period - pulmonary (4), pleural (1), miliary (1), lymph node (4) and pericardial (1). There was no mortality due to tuberculosis. Thorough search for tuberculosis is mandatory both during pre-transplant assessment and post-transplant follow-up in areas of endemic tuberculosis.

Adult↗
PubMed1986

Neurointermediate lobe transplanted under the kidney capsule modifies the activity of the neurointermediate lobe in situ, but does not respond to opiate treatment.

To investigate the possibility of a direct effect of morphine on the pars intermedia cells of the pituitary gland, rat neurointermediate lobes (NIL) were transplanted under the kidney capsule. At 2 and 8 days posttransplantation the NIL transplant had maintained its morphological integrity. However, at 15 days posttransplantation the morphological integrity of the NIL transplant had started to deteriorate. The NIL transplant contained, synthesized, and released beta-endorphin-like peptides. It was noticed that there was very little beta-endorphin in the radiolabelled biosynthesized products, suggesting that either the maturation processing of proopiomelanocortin was modified, or that beta-endorphin was released immediately as soon as it was formed and did not accumulate in the tissue. In support of the latter possibility was the elevated content of beta-endorphin-like immunoreactivity in the sera of rats with a NIL under the kidney capsule. Furthermore, the NIL transplant seemed to produce a substance or substances which could decrease the content, the biosynthesis and the release of beta-endorphin-like peptides by the NIL in situ. Treatment with either morphine or naloxone for 5 days did not change the beta-endorphin-like immunoreactivity content in the NIL transplanted under the kidney capsule. However, a distinct decrease in the beta-endorphin-like immunoreactivity in the NIL in situ of animals with or without a NIL transplant was observed following the morphine treatment. Naloxone treatment induced a decrease in the beta-endorphin-like immunoreactivity content in the hypothalamus, but had no effect on the beta-endorphin-like immunoreactivity content in the anterior lobe and NIL of the pituitary gland in situ or in the NIL transplant.

Animals↗
PubMed1986

Nevus of Ota associated with neurofibromatosis.

An association of neurofibromatosis with nevus of Ota is described in a young woman. The association of these disorders demonstrates a true proliferative process of neuroectodermal tissue.

Adolescent↗
PubMed1985

Endorphins in inbred mice with variable sensitivity to ethanol: effect of acute ethanol treatment.

Resting levels of beta-endorphin like immunoreactivity were determined in the hypothalamus, neurointermediate lobe and anterior lobe of the pituitary gland and the serum of inbred mice strains (C57BL/6, BALB/C and DBA/2). C57BL/6 mice showed the highest content of beta-endorphin like immunoreactivity in the neurointermediate lobe, anterior lobe and serum. Animals were injected i.p. with either an ethanol solution (3g ethanol/Kg b. wt.) or saline. 45 minutes post ethanol treatment the beta-endorphin like immunoreactivity content was increased in the serum of all three strains of mice studied and was decreased in the hypothalamus of the C57BL/6 mice. Studies with reverse phace HPLC indicated some differences in the relative proportions of the various forms of beta-endorphin in some tissues among the three strains of mice. These results suggest that genetically determined differences in endorphin levels may be involved in some of the genetically determined differences in responses to ethanol.

Animals↗