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Biomedical subjects

A Gulsvik

Publications and source records attributed to A Gulsvik.

At least 163 records · Page 9Linked to original sources
PubMed1979

Alpha 1-antitrypsin phenotypes and obstructive lung disease in the city of Oslo.

In a community survey in Oslo, Norway, comprising 1268 persons, alpha 1-antitrypsin concentration in serum (AT) and protease-inhibitor (Pi) phenotypes were examined in 1258 subjects. Estimated percentage distribution of Pi-phenotypes in the target population aged 15--70 years was M 87.30%, MS 4.65%, MZ 4.73%, FM 2.69%, SZ 0.13%, IM 0.20%, FZ 0.07%, S 0.06%, FS 0.07% and Z 0.06%. The distribution curve of AT had a normal (Gaussian) shape and the ranges of AT demonstrated great overlap of types MS and MZ with type M. In subjects with phenotype MZ neither respiratory symptoms nor physicians' diagnoses of chronic obstructive lung disease (COLD) were more frequent than in M subjects. Physicians' diagnoses of COLD were slightly more frequent (0.06 greater than P greater than 0.01) in subjects with phenotype MS than M, probably due to there being more smokers in the MS group. Spirometric variables given as per-cent of predicted values yielded large differences between smokers and non-smokers but no differences among phenotypes M, MS and MZ. Radiologic signs of hypertransradiancy and/or emphysema were evently distributed in M, MS and MZ subjects. The only subject observed with Pi-type Z and one out of three subjects with type SZ had COLD. In neither smokers nor non-smokers is phenotype MZ a risk factor of clinical importance for development of obstructive lung disease.

Adolescent↗
PubMed1979

Prevalence of respiratory symptoms in the city of Oslo.

In the first phase of a two-phase cross-sectional survey conducted in Oslo from 1972 to 1974 a questionnaire was mailed to a random sample of 19998 persons aged 15 to 70 years. Information was received from 88.7% of those alive in the sample. The completion rate for each of 11 questions on respiratory symptoms in the mail questionaire varied between 94 and 98%. The crude prevalence rates of the symptoms cough in the morning, breathlessness climbing two flights of stairs and wheezing were 24%, 11% and 17%. Only 27% of the men and 46% of the women in the survey population were non-smokers. Among non-smokers, phlegm was reported more fequently by men, irrespectively of age, whereas breathlessness was reported more often by women than by men. In both sexes of non-smokers, a linear increase in prevalence of symptoms with age was observed for breathlessness, attacks of breathlessness, and coughing in the morning and during the day. The prevalence of respiratory symptoms was closely related to the amount smoked.

Adolescent↗
PubMed1979

Prevalence and manifestations of obstructive lung disease in the city of Oslo.

A stratified random sample of 1209 subjects aged 16--69 was examined in Oslo, Norway in 1973--74 by a team of 11 chest physicians. They used information from a standardized interview and clinical examination, radiographs and ventilatory function tests to make a diagnostic decision. The within-observer agreement for the diagnosis bronchial asthma and the composite group obstructive lung disease (OLD) was 87% and 80%, respectively. More than 80% of maximal between-observer agreement was observed for these two entities. The point prevalence estimate of chest physicians' diagnosis of obstructive lung disease (OLD) was 5.5%, comprising bronchial asthma 1.4% and chronic obstructive lung disease (COLD) 4.1%. The prevalence of COLD increased with age, and it was four times more frequent in smokers/ex-smokers than in non-smokers. The prevalence of bronchial asthma showed no relation to age or smoking. Individuals aged 20--69 years with bronchial asthma, COLD and OLD, had 1 sec forced expiratory volumes of 83%, 71% and 74% of predicted values, respectively. A previous history of hay fever was reported five times more frequently by those with bronchial asthma than in the survey population. Disability pension was received by 15% of those with OLD.

Adolescent↗
PubMed1978

Cardiac arrhythmias in patients with serious pulmonary diseases.

During a 5-year period, 1969-1973, 451 patients with acute severe pulmonary diseases were admitted to the three medical intensive care units (MICU) at Ullevaal Hospital. In 39% of the patients a major cardiac arrhythmia was recorded in the units during a mean observation time of 24 h. The subsequent mortality in the hospital was 31% in patients with arrhythmias in the MICU, and 8% in patients without arrhythmias. The association between arrhythmias and mortality was significant (P less than 0.004) in patients with a diagnosis of pneumonia. There was also an association (P less than 0.04) between arrhythmias and the severity of lung disease. Continuous electrocardiographic monitoring of patients with severe pneumonia or acute exacerbations of obstructive lung disease is recommended.

Acute Disease↗