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Biomedical subjects

A Grieco

Publications and source records attributed to A Grieco.

At least 73 records · Page 4Linked to original sources
PubMed1987

High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer.

The therapeutic activity of 5-FU in large bowel cancer is enhanced by increasing the intracellular pool of reduced folates. We treated 45 patients with advanced colon cancer with HDFA and 5-FU for 5 consecutive days. None had been given previous radio- or chemotherapy. All had measurable disease. Not one complete response was observed. Thirteen of the 39 evaluable patients showed partial response. Median duration of response was 9+ months. The probability of 50% survival was 15 months for all evaluable patients. There was no case of severe toxicity and the principal toxic effects were oral mucositis and diarrhea. To date, HDFA + 5-FU is one of the most effective treatments for large bowel cancer.

Adult↗
PubMed1987

Intravenous diltiazem in the treatment of unstable angina: a study of efficacy and tolerance.

Ten patients four men and six women aged 35 to 78 years (mean, 57) who had been admitted to a coronary care unit because of unstable angina, received intravenous infusions of diltiazem for three to ten days after a 24-hour observation period. During the observation and treatment periods, the patients were monitored daily for number of attacks of angina, nitroglycerin intake, blood pressure, and ECG parameters. Routine laboratory tests were performed before and after diltiazem therapy. Two patients did not respond to treatment, but administration of diltiazem controlled anginal pain in eight patients, without producing side effects. In one case the dose had to be reduced because of atrioventricular dissociation; in three cases there was a modest increase in SGPT. Diltiazem was found to be a safe and effective drug for controlling anginal attacks in patients with unstable angina.

Adult↗
PubMed1986

Comparison of bronchodilator effects of Duovent and Reproterol in patients with chronic reversible airway obstruction.

The bronchodilator effect of Duovent (a combination of a beta-2-agonist, fenoterol, and an anticholinergic, ipratropium bromide) was compared with that of Reproterol (a pharmacological hybrid which presents both resorcinol and theophylline portions) in 16 patients suffering from chronic reversible airway obstruction. Each of the 16 patients (14 males and 2 females, mean age 65.8 years) had a baseline FEV1 ranging from 30 to 70% of their predicted values (CECA values) (mean value +/- SE of the group: 1,238 +/- 78 ml), which increased at least 15% after the inhalation of two puffs of 400 micrograms fenoterol (percent increase of the group: 26.5 +/- 2%, mean +/- SE). This single-blind study was carried out on 3 different days, between 8:30 a.m. and 4:30 p.m. After measurement of the baseline functional parameters [FVC (forced vital capacity), FEV1 (1-second forced expiratory volume), and FEF25-75 (forced expiratory flow between 25 and 75% of vital capacity)], each patient was given two puffs of placebo the 2nd day, and either of Duovent (200 micrograms of fenoterol and 80 micrograms of ipratropium bromide) or of Reproterol (1 mg) the 1st or the 3rd day, at random. The measurements of functional parameters were repeated after 30, 120, 240, 360 and 480 min. Blood pressure, heart rate and possible side effects were recorded at the same time. Both Duovent and Reproterol, at all times, produced a statistically significant increase in FEV1 and FEF25-75.(ABSTRACT TRUNCATED AT 250 WORDS)

Atropine Derivatives↗
PubMed1985

Can glycosylated hemoglobin be a job stress parameter?

Glycosylated hemoglobin (HbA1c) levels are evaluated as a possible integrated measure parameter of chronic job stress. HbA1c and fasting blood glucose levels in 100 healthy male printing workers (pressmen) exposed to noise, rotating shifts, and overwork were compared with levels measured in 200 healthy male clerical workers not exposed to those stressors. While blood glucose levels and their variability were found to be approximately the same in both groups, HbA1c levels were found to be 8.64% higher among the pressmen and this difference was significant at p less than .001. These findings support the hypothesis, and further research to confirm the test is suggested.

Adult↗
PubMed1984

Investigation of the Karnofsky Performance Status as a measure of quality of life.

The Karnofsky Performance Status appears to be the most widely used scale for objective assessment of medical patients' quality of life. Evidence for its reliability and validity is reviewed and new data presented. Tests of inter-rater reliability, concurrent validity, and discriminant validity indicate that, with standardized observational procedures based on a mental status exam, the Karnofsky scale is acceptably reliable and valid as a global measure but it does not adequately capture the conceptual domain of quality of life.

Aged↗
PubMed1984

Clinical trial of combined hormone therapy (MAP + TAM) for metastatic breast cancer.

High dose MAP (medroxyprogesterone acetate) and TAM (tamoxifen) were administered orally to 31 postmenopausal patients with advanced breast cancer. CR (complete remission) was achieved in 1 (3%) and PR (partial remission) in 11 (32%) patients for a median duration of 12 months. The treatment was well tolerated and in no instance was interrupted because of toxicity. This study does not support the hypothesis that the combination of MAP and TAM gives better results than the single agents.

Aged↗