Narcissism, to which so many theoretical works have ben devoted during these last few years in France, has been the object of very few clinical studies. An earlier work (1963) on the phallic-narcissistic position led me to define more accurately a state observed in the clinic and first described by Reich. I should now like to give a more solid contour to another clinical impression, to verify its validity in individual experience and, if possible, to attribute a structure to it. We shall now take up the matter of moral narcissism.

Adolescent↗

PubMedDate not supplied

A cell line derived from a clinically benign phyllodes tumor: characterization and implications.

Phyllodes are uncommon tumors of the breast. Improved understanding of their behavior is hampered by the paucity of good laboratory models. We have developed two cell lines, by both xenograft and direct cell culture, derived from a histologically benign phyllodes tumor. Both cell lines have the same characteristics and growth kinetics. They grow as monolayers of spindle-shaped cells, with surface markers consistent with a mesenchymal origin. They do not express either estrogen or progesterone receptors. The cells have a relatively short doubling time of just over 1.5 days, and show a stimulatory effect with the addition of insulin. Karyotype analysis reveals the absence of one X chromosome.

Animals↗

PubMedDate not supplied

Establishment of a human melanoma cell line lacking p53 expression and spontaneously metastasizing in nude mice.

Nine human melanoma cell lines established in our laboratory were analyzed for p53 gene expression and their tumorigenic and metastatic potential in nude mice. Northern blot analyses showed that five of the cell lines (55%) had either complete loss or low levels of p53 transcripts. Immunocytochemical analysis for p53 protein expression agreed with mRNA analysis results. Nucleotide sequencing showed no mutations in exons 5 through 8 of the gene. All cell lines except one gave rise to tumors at subcutaneous inoculation sites in nude mice. The melanoma cell line UISO-MEL-6, completely lacking p53 expression, spontaneously metastasized to lung and liver in nude mice.

Animals↗