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Biomedical subjects

A Green

Publications and source records attributed to A Green.

At least 721 records · Page 40Linked to original sources
PubMedDate not supplied

Epidemiologic and public health aspects of insulin-treated diabetes in Denmark.

The epidemiology, mortality, and use of hospital services of insulin-treated diabetes mellitus have been studied in Fyn County, Denmark (450,000 inhabitants). The overall prevalence rate was 3.6 and 3.3 per 1000 for men and women, respectively, and overall annual incidence rates have been estimated to be 15 and 11 per 100,000, respectively. Based on a mortality analysis, it is estimated that the overall mortality rate in this patient population is 4-5% per year. During follow-up, hospital admission rates were estimated to be 0.47 and 0.53 per patient person-yr for men and women, respectively; corresponding values for estimated number of hospital bed days used by the patients were 7.2 and 9.6 per person-yr. Only 26% of the patients (74% in the age class 0-9 yr) attended a diabetes outpatient clinic at the prevalence date (1 July 1973); the remaining patients were supervised by their general practitioner. Based on these figures, an epidemiologic model for insulin-treated diabetes has been formulated, and it is concluded that this disease represents a major public health problem.

Adolescent↗
PubMedDate not supplied

Computerized measurement of ciliary beat frequency.

We describe how ciliary beat frequency (CBF) of human respiratory epithelium in vitro can be robustly and quickly measured. The proven photometric technique has been improved by using a microcomputer to calculate and display the results. The software, which runs on an IBM-compatible PC, was developed using Borland Turbo Pascal and employs a fast Fourier transform routine to derive the CBF. Results are displayed almost as soon as a cell is identified under the microscope, and are in accordance with previous work. The technique can now be used diagnostically and for a variety of drug trials on respiratory epithelium.

Adult↗
PubMedDate not supplied

Buteyko breathing techniques in asthma: a blinded randomised controlled trial.

OBJECTIVE: To evaluate the effect of Buteyko breathing techniques (BBT) in the management of asthma. DESIGN: Prospective, blinded, randomised study comparing the effect of BBT with control classes in 39 subjects with asthma. The study was conducted from January 1995 to April 1995. PARTICIPANTS AND SETTING: Subjects recruited from the community, aged 12 to 70 years, with asthma and substantial medication use. MAIN OUTCOME MEASURES: Medication use; morning peak expiratory flow (PEF); forced expiratory volume in one second (FEV1); end-tidal (ET) CO2; resting minute volume (MV); and quality of life (QOL) score, measured at three months. RESULTS: No change in daily PEF or FEV1 was noted in either group. At three months, the BBT group had a median reduction in daily beta 2-agonist dose of 904 micrograms (range, 29 micrograms to 3129 micrograms), whereas the control group had a median reduction of 57 micrograms (range, -2343 micrograms to 1143 micrograms) (P = 0.002). Daily inhaled steroid dose fell 49% (range, -100% to 150%) for the BBT group and 0 (range, -82% to +100%) for the control group (P = 0.06). A trend towards greater improvement in QOL score was noted for BBT subjects (P = 0.09). Initial MV was high and similar in both groups; by three months, MV was lower in the BBT group than in the control group (P = 0.004). ET CO2 was low in both groups and did not change with treatment. CONCLUSION: Those practising BBT reduced hyperventilation and their use of beta 2-agonists. A trend toward reduced inhaled steroid use and better quality of life was observed in these patients without objective changes in measures of airway calibre.

Adolescent↗
PubMedDate not supplied

The evolution of a distance education initiative into a major telehealth project.

After a five-year collaboration in distance learning, the University of Texas Medical Branch in Galveston School of Nursing and the Lamar University Department of Nursing in Beaumont, Texas, opened discussions during the mid-1990s about working together to establish a cutting-edge telehealth clinic. Other participants in this dialogue were the UTMB Division of Pediatric Special Services (DPSS) and the East Texas Area Health Education Center (ETAHEC). DPSS hoped to provide telehealth services for children who had to commute routinely to receive comprehensive health care. ETAHEC, which specializes in building community-academic partnerships to improve the health of populations in its service region, had already worked with members of the team, providing support for the distance education collaboration between UTMB and LU. Several meetings between representatives from the two universities and ETAHEC resulted in the decision by LU to establish an infrastructure for distance learning that could also support telehealth activities. UTMB, which offered family nurse practitioner education at LU through the earlier distance learning initiative, had extensive experience in both distance education and telehealth. It provided the expertise to ensure that the two types of technology could be provided on the LU campus. Eventually, a third university came on board, and the program expanded to provide services in six public schools. A single telehealth clinic, in operation for two years with over 112 client visits, has grown into a major telehealth initiative linking an academic health science center, universities, and school districts in Texas.

Child Health Services↗
PubMedDate not supplied

Increased trend of type 1 diabetes mellitus in children's population (0-14 years) in Upper Silesia region (Poland).

UNLABELLED: THE PURPOSE OF THE STUDY was to provide current and reliable information about trends in the incidence rates of Type 1 Diabetes in the Upper Silesia region in children aged 0-15 years in the period of 9 years. RESULTS: Incidence ratio in the examined population increased from 4.71 in 1989 up to 10.16/100,000/year in 1997. In the analysed group no significant statistical differences dependent on sex were found. During the examined period, the incidence ratio has increased significantly. It was observed that the extent of change varied in different age groups. The youngest children (0-4 years old) showed the greatest increase of the incidence ratio from 1.09/10(5) in 1989 up to 6.75/10(5) in 1997. The highest incidence ratio was observed in the group of 10-14 year-olds. CONCLUSIONS: In the examined period dramatic increase (more than 200%) of the incidence ratio of type 1 diabetes was reported in the children's population (0-14 year-olds) in Upper Silesia. The fastest increase in this ratio was established in the group of youngest children (0-4 years old).

Adolescent↗
PubMedDate not supplied

Human breast carcinoma cell lines: ultrastructural, genotypic, and immunocytochemical characterization.

Two new breast carcinoma cell lines, designated as UISO-BCA-1 and UISO-BCA-2, have been established from pleural effusions of postmenopausal women. Both cell lines show properties of mammary epithelial cells, such as positive immunoreactivity to cytokeratins and human milk fat globulin, presence of desmosomal junctions, numerous microvilli, intracytoplasmic duct-like vacuoles and tonofilaments. UISO-BCA-1 and UISO-BCA-2 cells differ from each other with respect to cellular morphology, ultramicroscopic details, immunoreactivity to Her-neu oncogene protein, chromosomal mode and in vivo and in vitro growth rates. UISO-BCA-1 cells are well-differentiated (as evident from their morphology and ultrastructural details) and hyperploid (42-114 chromosomes). In vitro, UISO-BCA-1 cells are fast growing, with a population doubling time of 31.2 +/- 9.6 hrs (n = 4), and are tumorigenic (100%) in athymic nude mice. In contrast, UISO-BCA-2 cells are poorly differentiated, but are also hyperploid, with 54-64 chromosomes. UISO-BCA-2 cells are slow growing in vitro (population doubling time: 56.0 +/- 5.0 hrs [n = 4]) and have limited tumorigenic potency (20-40%). Both these cell lines are estrogen and progesterone receptor (less than 10 fmol/mg protein) negative.

Aged↗
PubMedDate not supplied

Cholangiocarcinoma in north east Thailand. A hospital-based study.

The population of Northeast Thailand has one of the highest known rates of cholangiocarcinoma (cancer of the bile ducts). We sought firstly to obtain an estimate of the frequency of hospital-based diagnosis of cholangiocarcinoma in the northeastern province of Khon Kaen. All pathology, ultrasound and in-patient and out-patient records were searched for cases diagnosed in tertiary hospitals in a random calendar month in 1988. A total of 203 persons from various parts of northeastern Thailand were newly-diagnosed in the two hospitals, 75 of whom resided in Khon Kaen province. We estimated the minimal age-standardised annual incidence rate in this province to be 135.4 per 100,000 among males and 43.0 per 100,000 among females (world standard). Truncated standardised incidence rates (ages 35-64 years only) were 334.2 and 104.3 per 100,000 for males and females respectively. Secondly we aimed to assess the feasibility of secondary prevention by early clinical diagnosis. However, the symptoms and signs observed were typically non-specific and associated with advanced disease in patients with cholangiocarcinoma who presented to hospital. Primary preventive measures appear to be the key to decreasing the mortality from this disease.

Adenoma, Bile Duct↗
PubMedDate not supplied

Skin blade versus deep blade: a vehicle of contamination in podiatric surgery.

A total of 166 surgical blades consisting of control blades, skin blades, and deep blades were cultured from 50 elective podiatric surgical cases. Five blades from four cases cultured Staphylococcus epidermidis. The practice of changing from skin blade to deep blade to reduce contamination of a clean surgical wound is not supported by the data obtained in this study.

Disinfection↗
PubMedDate not supplied

Comparison of 51Cr-EDTA and 99mTc-DTPA slope clearances in children with vesicoureteric reflux.

The plasma clearances of 51Cr-EDTA and 99mTc-DTPA have been compared in a series of 154 children with reflux nephropathy. The study has shown that DTPA can replace EDTA with the advantage that it can also be used for dynamic renal imaging and calculation of individual kidney function. However, the source of the DTPA is important, as it has been shown to affect the comparison with EDTA clearance.

Child↗
PubMedDate not supplied

Depression, anxiety and rheumatoid arthritis activity.

The temporal relationship of rheumatoid arthritis activity and mood has rarely been studied and the findings have been unclear. This study focuses on this problem in a prospective, multiple assessment design. Depression, anxiety, and rheumatoid arthritis (R.A.) variables were assessed weekly during hospitalization and monthly for six months after discharge in a sample of 39 patients. Evidence was found for a relationship between depression and increased R.A. activity occurring in association with clinically relevant R.A. related events such as flare-ups leading to hospitalization, improvement resulting from hospitalization, and adjustment after discharge. No evidence was found for relationships between depression, anxiety, and less dramatic changes in R.A. variables occurring during regular weekly in-hospital and monthly post-hospital assessments. The results demonstrate the inadequacy of assessments done at one point in time and also suggest that somatic complaints such as reduced energy, disturbed sleep or poor appetite may be associated as much with depression as R.A. activity.

Adult↗