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Biomedical subjects

A Gordon

Publications and source records attributed to A Gordon.

At least 253 records · Page 14Linked to original sources
PubMed1981

Abnormalities of the spinal meninges in anencephalic fetuses.

The spinal cord and meninges were examined, at all levels, in seven anencephalic fetuses of between 19 and 24 weeks of gestation. Four of the seven anencephalics showed dense collections of cells resembling immature neural tissue throughout the spinal subarachnoid space. The leptomeninges were excessively vascular and contained many active macrophages and small round cells in all the anencephalics and the cord was more slender than normal. Control fetuses did not show these features, although inactive macrophages were seen occasionally. It is concluded that the abnormal collections are made up of heterotopic neural tissue which may have been dislodged downwards from the skull during earlier development and that the spinal leptomeninges show an inflammatory response. The significance of both the heterotopia and the phagocytic activity in these anencephalic fetuses is discussed. In particular, the findings are compared with those in patients with the "respirator brain" syndrome, in whom displacement of brain tissue is associated with raised intracranial pressure.

Anencephaly↗
PubMed1981

Decerebrate rigidity produced in cats by focal stereotactic radiofrequency lesions.

A method of producing decerebrate rigidity in cats by means of a radio frequency current was developed. Adequate control of the extent an shape of the lesions necessitated a preliminary investigation of the relationship between the intensity and duration of current, the size of the lesion, and the tissue impedance before and after destruction; this was performed on guinea pigs. The mesencephalic reticulum in cats was identified by depth microelectrode recording and electrical stimulation. Unilateral, midline, and combined stereotactic radiofrequency lesions were made. The anatomical location, the pathological characteristics, and the physiological significance of the lesions with regard to the production of decerebrate rigidity and of the other clinical reactions of the animals are discussed.

Animals↗
PubMed1981

Identification of a mitochondrial phosphoprotein in brain synaptic membrane preparations.

A 41,000-dalton phosphoprotein in crude synaptosomal membrane fractions is characterized by its unique divalent and monovalent cation regulation. It is identified by two-dimensional gel electrophoresis as the phosphoprotein whose phosphorylation is enhanced by repetitive electrical stimulation of hippocampal brain slices. After sucrose-gradient ultracentrifugation, this phosphoprotein is found in the mitochondrial subfraction. This suggests that the electrically produced changes in the level of phosphorylation of the 41,000-dalton polypeptide are probably effects on cellular energetics rather than on specialized neural membrane function.

Animals↗
PubMed1981

The synthesis and release of TSH in the thyroidectomized rat: c) the effect of T3 on hypothyroidism of varying duration.

The effect of thyroid hormones on TSH synthesis and release from the anterior pituitary of the rat, at the various stages of hypothyroidism was studied by injecting L-Triiodothyronine (T3) iv (1.5 microgram/100 g b.w.) to rats 5 days and 3 months post thyroidectomy (Tx-5d and Tx-3m rats). The changes in plasma and pituitary TSH levels, as well as in the metabolic clearance rate (MCR) of the TSH were followed for 3 days after the T3 injection. From these data TSH synthesis and release rates were determined. TSH release was inhibited in both experimental groups between 3 and 24 h after the injection. TSH synthesis was suppressed in the Tx-5d group to 35% of the initial value. However in the Tx-3m group it was stimulated to approximately 270%, 24 h after the T3. The data suggest that thyroid hormones may affect the synthesis of TSH in two opposite pathways, the first through the stimulation of protein synthesis and the second, inhibitory, as part of the feedback mechanism. Under short-term hypothyroidism, when protein synthesis is not yet diminished, the administration of thyroid hormones results in the inhibition of both TSH synthesis and release through the feedback regulation. In prolonged hypothyroidism, however, when protein synthesis is depressed, the effect of thyroid hormones on the stimulation of TSH synthesis predominates.

Animals↗
PubMed1981

Dysgerminoma: a review of 158 cases from the Emil Novak Ovarian Tumor Registry.

One hundred and fifty-eight dysgerminomas from the Emil Novak Ovarian Tumor Registry and the Gynecologic Pathology Laboratory of The Johns Hopkins Hospital were reviewed. Five-year follow-up was available for 82% and 10-year follow-up was available for 65%, with survival rates of 83% and 74% for pure tumors, respectively. Survival was related to stage of disease and presence of other germ cell elements. Patients treated by unilateral adnexectomy alone for stage IA pure dysgerminoma had a 95% 5-year survival. Survival of these patients was not affected by tumor size.

Adolescent↗
PubMed1980

Benign cystic teratomas in postmenopausal women.

Postmenopausal benign cystic teratomas occurred in 16 women in a 6-year period. In this group the incidence of malignancy was 19%, and the incidence of bilaterality was 20%. Marked collagenization of the tissue of the teratoma indicated an "end-stage" process. The high incidence of malignancy in this group of patients in an indication for vigorous surgical staging for extent of disease.

Adolescent↗
PubMed1980

Neurochemical observations in a case of Pick's disease.

Neurochemical markers of the activities of the cholinergic, gabaergic and dopaminergic systems were measured in post-mortem brain from a case of Pick's disease. No marked changes were found in the activities of choline acetyltransferase, acetylcholinesterase, L-glutamic acid decarboxylase and the concentration of dopamine. In areas of brain showing no histological changes, muscarinic receptor binding was within the normal range. In the cerebral cortex, which exhibited the neuropathological features of Pick's disease, the number of muscarinic cholinergic binding sites was much reduced, suggesting that the cortical neurones which are lost in Pick's disease are cholinoceptive.

Acetylcholinesterase↗
PubMed1980

The metabolism of T4 and T3 in cultured chick-embryo heart cells.

Thyroxine (T4) and tri-iodothyronine (T3) were metabolized in cultured chick-embryo heart cells via inner-ring de-iodination and O-sulfation. The products of T3 metabolism were 3,3'T2, 3'T1, and sulfated esters of T3 and 3,3'T2. The major product of T4 degradation was 3,3',5'-T3 (rT3). ONo T3 was produced from T4. Propylthioracil inhibited the metabolism of T3. Pretreatment of cultures with T3 or T4 enhanced the metabolism of both hormones; actinomycin D and cycloheximide inhibited the stimulatory effect of T3. The stimulation by T3 was linearly related to the log of the concentration of T3 in cells grown in normal chick serum or in cells grown in dehormonized serum. These results suggest that thyroid hormones induced an increased synthesis of the enzymes involved in their metabolism and therefore may regulate their own disposal rate.

Animals↗
PubMed1980

Two methods of measuring muscle tone applied in patients with decerebrate rigidity.

Two methods were used to measure muscle tone in patients with decerebrate rigidity. In the first method forces of square waveform were applied and the calculated compliance of the joint was used as an index of rigidity. Oscillatory transients were seen at the same frequency as the physiological tremor. The range of normal variation in compliance was large and the values measured in the patients flucuated markedly which limited the value of this index. In the second method, where forces of sinusoidal waveform were employed, the resonant frequency of the joint was measured and used as an index of rigidity. This index proved reliable and reproducible.

Adolescent↗
PubMed1980

Problems in the psychotherapy of children with histories of incest.

Therapists must be cognizant of the meaning of the patients' presentation and the extreme need for therapeutic safety. The therapists must be keenly aware of the deprivation issues for these patients and not be seduced by the sexual "red herring." At the same time, the therapist must be careful that his own discomfort does not make him run away from the sexual material. Thus the therapist must strike a difficult balance between the two. The therapist must avoid allying with the child solely as a victim, an alliance which would hinder an understanding of the child's motivation and subsequent guilt, and thus foster further difficulties. The therapist must work through his own outrage that a child has been molested so that he may avoid blame seeking. By attending to these issues, the individual psychotherapist will pass the patients' "test" and take the first step in helping patients and their families in forming a therapeutic working alliance.

Adolescent↗
PubMed1980

Controlled trial of sulpiride in chronic schizophrenic patients.

In a double-blind comparative trial of sulpiride (600-1,800 mg/day) and trifluoperazine (15-45 mg/day) in 38 chronic schizophrenic patients, ratings of therapeutic results and unwanted effects were made at two-weekly interviews during the six weeks treatment period. The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine. There was an association between plasma sulpiride levels and therapeutic response after four weeks' treatment.

Adult↗