Search PubMed⌕ Search

Biomedical subjects

A Ghosh

Publications and source records attributed to A Ghosh.

At least 397 records · Page 22Linked to original sources

Three-dimensional reconstruction of echo-cardiographic images using the rotation method.

We describe a method for three-dimensional reconstruction of real time two-dimensional echocardiographic images using a rotation method. Seven tissue specimens were studied in a water bath and two-dimensional images were recorded by rotating the transducer every 30 degrees, from 0 to 180 degrees. Angular reconstruction of areas was obtained at different axial locations and volumes calculated by a Sigma 9 computer using axial summation without geometric assumptions. Using spatial coordinate data, three-dimensional perspective images could be plotted by the computer in any desired view. The volumes obtained by this method (range 90-231 ml) corresponded closely (R = 0.96) with volumes measured directly by water displacement (range 95-200 ml). Two patients were also studied with this technique by placing the transducer at the cardiac apex to record two-dimensional left ventricular and diastolic and end systolic images. Three-dimensional reconstructed volumes closely correlated with those obtained by left ventricular angiography. Ejection fraction in one patient was 52% by three-dimensional reconstruction, 47% by angiocardiography. In the other patient, the ejection fraction was 76% by three-dimensional imaging, 69% by angiocardiography. This preliminary study demonstrates the feasibility and simplicity of three-dimensional reconstruction using the rotation method.

Adult↗

Prognostic significance of raised serum alpha-fetoprotein levels in twin pregnancies.

Maternal serum alpha-fetoprotein (AFP) was measured during the second trimester in 219 twin pregnancies uncomplicated by neural-tube defects (NTD) and in 11 twin pregnancies discordant for NTD. Serum AFP levels were recorded in multiples of the median value (MOM) calculated from normal singleton pregnancies. Of the twin pregnancies uncomplicated by NTD 49% had AFP levels less than 2.5 MOM, 7.8% had levels greater than 5 MOM and 59% of these were associated with either abortion, stillbirth or fetus papyraceous. In twin pregnancies with serum AFP levels less than 5 MOM and unsuccessful outcome was noted in only 4% (chi 2, P less than 0.05). There was a significant negative correlation between serum AFP levels and combined birthweights (r = 0.954). All 11 pregnancies discordant for NTD had serum AFP values greater than 5 MOM and this level appears to be a suitable cut-off point above which there should be further diagnostic investigations and monitoring of fetal well-being.

Birth Weight↗

Identification of the polyprotein termination site on encephalomyocarditis viral RNA.

We show by sequence analysis of a 420-base-long region adjacent to the 3' polyadenylic acid of encephalomyocarditis viral RNA and by carboxy terminus analysis of protein E that the termination site of encephalomyocarditis virus polyprotein translation consists of two successive UAG codons located at positions 121 to 126 from the 3' polyadenylic acid.

Base Sequence↗

Direct assessment of depression by microcomputer. A feasibility study.

A self-rating depression questionnaire based on the Hamilton Depression Questionnaire was given directly by a microcomputer to 43 controls and 125 depressed patients. Scores obtained from the two groups differed very significantly; choosing an appropriate cut-off point, the computer-delivered questionnaire accurately detected the presence of depression. The severity of depression in the patients, as indicated by their scores, correlated significantly with assessments of severity by qualified clinicians. Patients commented favourably on the procedure, and the medical and nursing staff found it instructive and helpful. The use of this technique appears practicable and further evaluation is in progress.

Computers↗

Characterization of the coat protein mRNA of southern bean mosaic virus and its relationship to the genomic RNA.

RNA isolated from southern bean mosaic virions contains, in small amount, a subgenomic RNA (molecular weight, 0.38 x 10(6)) that serves in vitro as an mRNA for southern bean mosaic virus coat protein. The RNA has a 5'-linked protein indistinguishable from the protein linked to the 5' end of full-length genomic RNA. Its base sequence, determined to 91 bases from the 3' end, is identical to the 3'-terminal sequence of the genomic RNA. The results suggest that the coat protein messenger sequence exists as a "silent" cistron near the 3' end of the genomic RNA.

Journal Article↗

Socio-economic status and mental morbidity in certain tribes and castes in India--a cross-cultural study.

The authors made a field-survey of mental morbidity in all the tribal and caste groups residing in a cluster of villages in West Bengal, India, and found that, in each group, higher socio-economic classes had higher rates of mental morbidity. Different groups having a similar cultural pattern showed no significant difference in their rates of morbidity. Groups having different cultural patterns differed significantly in their rates of morbidity. In the tribal groups some neurotic disorders were absent.

Cross-Cultural Comparison↗

Southern bean mosaic viral RNA has a 5'-linked protein but lacks 3' terminal poly(A).

Nuclease digestion of SBMV RNA releases a protein of molecular weight approximately 12,000 in addition to the four mononucleotides. The lack of reactivity of SBMV RNA to polynucleotide kinase and the absence of a capping group suggest that the protein is covalently attached to the 5' end of the RNA. RNA sequencing shows that the 3' terminus of SBMV RNA is not polyadenylated.

Base Sequence↗

Socio-economic status and prevalence of mental disorders in certain rural communities in India.

A psychiatric field-survey was conducted in three villages in West Bengal, India in order to correlate the prevalence of mental morbidity with the socio-economic status of the families. The sample was divided into four groups on the basis of religion or caste. Total morbidity had no statistically significant relationship with socio-economic status in any of the four groups. In the total sample it was directly related. Higher classes had significantly higher rates. Psychoses were not correlated with socio-economic status in any of the groups. Neuroses showed a significantly higher rate in the upper strata of two groups; in the other two groups the trend of prevalence was in the same direction. The four groups had significant differences in their rates of total morbidity. In all the groups females had a higher rate of mental morbidity. Psychoses, Neuroses and Depression were commoner in females and Schizophrenia was commoner in males.

Adolescent↗