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Biomedical subjects

A German

Publications and source records attributed to A German.

117 records · Page 7Linked to original sources
PubMedDate not supplied

[Role of macrophages in interferon production in mice (author's transl)].

By stimulating or depressing the macrophage system with Corynebacterium parvum or anti-macrophage serum, we were able to establish that macrophages play a role in Poly-I:C-induced interferon production. On the other hand macrophages do not seem to be the cells which produce endotoxin- or NDV-induced interferon, although a slight participation of these cells in the production of NDV-induced interferon cannot be excluded.

Animals↗
PubMedDate not supplied

[Digestive and cutaneous colonization of Staphylococcus epidermidis in hairless axenic mice].

In order to determine the cutaneous and digestive colonization of S. epidermidis in germ-free HRS mice, several groups of animals were contaminated with this strain according to different methods. The bacterial cutaneous enumerations were performed after preliminary crushing of the cutaneous biopsy. In this study, whatever the method of contamination of germ-free HRS mice, the kinetics of S. epidermidis cutaneous colonization was parallel to the kinetics of intestinal colonization. The isolation of bacteria on skin was possible only when microorganisms were eliminated in faeces (6 h after contamination). During a single experiment, there was only slight variability in colonization, whether intestinal or cutaneous. Some differences could be found from one experiment to another, but all animals in the same trial showed the same cutaneous bacterial count. This experimental model is characterized by an interrelation between the intestinal and cutaneous ecosystems.

Animals↗
PubMedDate not supplied

[Evaluation of bactericidal activity of antiseptics on the cutaneous flora of holoxenic hairless mouse].

Holoxenic Hairless mice were used in an experimental model to study the in vivo bactericidal activity of several antiseptics. In these experiments skin was sampled by biopsy; after contact between antiseptic and skin, bactericidal activity was neutralized. The results obtained with several products (polyvinylpyrrolidone iodine, alcoholic iodine, ethanol, chlorhexidin, benzalkonium chloride, mercurothiolic acid, trichlorocarbanilid and hexachlorophen) were quite similar to those obtained on human skin. The differences must be related to the composition of the Hairless mouse skin flora which contains Staphylococcus xylosus, Micrococcus sp. and Streptococcus faecalis, but does not contain Corynebacterium sp. or Propionibacterium sp.

Animals↗
PubMedDate not supplied

Air bags and children: a potentially lethal combination.

Air bags have been responsible for saving thousands of lives since their introduction in the early 1970s. Now, however, it has become apparent that under certain conditions, these restraint mechanisms designed to save lives have in fact been the cause of needless morbidity and mortality in children. We reviewed 13 children injured by air bags in Canada, where seat belt wear is mandatory for all occupants. Although 12 of the children sustained relatively minor air bag trauma, one child was killed by the air bag deployment, sustaining an occipital-C1 dislocation. The pediatric population is at particular risk as many parents continue to unwittingly place their children in the front seat and thus in jeopardy of sustaining air bag-induced injuries should a collision occur.

Accidents, Traffic↗