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Biomedical subjects

A German

Publications and source records attributed to A German.

At least 109 records · Page 6Linked to original sources
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[Digestive and cutaneous colonization of Staphylococcus aureus, Pseudomonas aeruginosa and Corynebacterium xerosis in germ-free hairless mice].

Regardless of the method of germ-free HRS mouse contamination, the kinetics of Staphylococcus aureus and Pseudomonas aeruginosa cutaneous colonization was parallel to the kinetics of intestinal colonization; Corynebacterium xerosis, however, was unable to colonize the skin or the gastrointestinal tract. There was little variability in intestinal and cutaneous colonization; this was quite different from observations in man and hairless holoxenic mice. It is possible to use these experimental models to standardize the measurement of antiseptic bactericidal activity in vivo.

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Rhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome.

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