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Biomedical subjects

A Galindo

Publications and source records attributed to A Galindo.

76 records · Page 5Linked to original sources
PubMedDate not supplied

Effect of psychotropic drugs on histamine H2-receptors in rat isolated uterus.

The effects of the monoamine oxidase inhibitors iproniazid, nialamide and phenelzine, the neuroleptics haloperidol and thioridazine, and the benzodiazepines diazepam and clonazepam on histamine H2-receptors were assessed on rat isolated uterus. The monoamine oxidase inhibitors showed a slight non-competitive antihistamine H2 activity, while diazepam and clonazepam were devoid of any action. Haloperidol and thioridazine inhibited in a dose-dependent manner the tonic component of KCl induced contraction, while thioridazine under the same conditions exhibited a slight antihistamine H2 activity. These data show that the drugs tested are devoid of or elicited only a slight antihistamine H2 activity at high non-therapeutic concentrations.

Animals↗
PubMedDate not supplied

[Use of the direct capping technic in lymphocytes for the detection of women carrying the Duchenne type muscular dystrophy].

Duchenne muscular dystrophy (DMD) is a progressive X-linked recessive condition. The detection of female carriers is important for genetic counseling but no precise method is available in our country. Based on the demonstration by other authors of an impaired lymphocyte "capping" in DMD patients and carriers, we evaluated the usefulness of this method in the detection of DMD carriers. Nineteen control subjects, 9 obligate carriers, 6 DMD patients, and 10 probable carriers, were studied. The analysis of variability intra and interobserver of the results of "capping" showed variation coefficients of 17% and 19%, respectively. The comparison of groups (F test) showed no difference between controls, obligate carriers and DMD patients. When a diagnostic value of 30 was chosen, we obtained 78% specificity and 40% sensitivity. It was concluded that, under the conditions of this study, we were unable to demonstrate a diminished lymphocyte "capping" in DMD patients and carriers as compared with normal subjects.

Adult↗