Effect of metoclopramide on transport in the small intestine of the dog.
A method is described for the simultaneous measurement of flow rate, mean transit time, and volume of the intestine during the transport of fluid through a segment of the small intestine of the dog. Using this method, the effect of metoclopramide on motility of the small bowel was assessed. The drug resulted in a decrease in transit time and volume in the test segment of bowel while the flow rate remained constant. This finding suggests that metoclopramide-stimulated contraction of intestinal smooth muscle.
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