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Biomedical subjects

A G Babaeva

Publications and source records attributed to A G Babaeva.

54 records · Page 3Linked to original sources
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[Reparative processes and immunity].

The published and author's data concerning changes in formation of antibodies to T-dependent antigen during regeneration of various organs in mammals are summarized. Significance of stress, functional transgression of the injured organs, products of tissue degradation and degree of organ tissue deficit for postoperative stimulation of antibody formation has been discussed. Interaction between the organ antigens and lymphoid tissue was shown to be important for changes of immunoreactivity. Dependence of the immune system postoperative stimulation on the organ tissue deficit is connected with the increase of the T-helpers/T-suppressors ratio in the spleen of operated animals. It has been proposed that the mechanism underlying the action of organ tissue deficit is connected with the loss of natural immunological tolerance to organospecific autoantigens.

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[Cellular and humoral immunity factors as regulators of regenerative morphogenesis].

The published and author's data concerning changes in the immune system during regeneration of various organs are summarized. During the first few hours after partial removal of organs possessing high regeneration capacity, lymphocytes stimulate proliferation of nonlymphoid cells of an organ identical to the operated one; the production of antibodies against thymus-dependent antigen also increases. At the following stages of regeneration, the lymphocytes suppress the cell proliferation and decrease the antigen production. The level of these changes correlates with the level of post operational deficiency of the organ being maximal after total removal of the organ. The functional properties of splenocytes at different stages of regeneration suggest that the high T-helper and T-suppressor activities correlate with stimulation and suppression of non-lymphoid cells proliferation respectively. Culture medium supernatant after cultivation of these lymphocytes also changes the proliferation of hepatocytes. The author considers the impairment of natural immune tolerance caused by deficiency of organ auto-antigens that normally suppress lymphocyte proliferation to be the cause of the changes in lymphocyte activity.

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[Effect of the spleen cells from partially splenectomized and partially hepatectomized mice on the proliferation of hepatocytes in the regenerating liver of syngeneic recipients].

Cells of mouse spleen obtained 48 h after foster splenectomy, foster hepatectomy, resection of 2/3 of spleen or 36 h after resection of 2/3 of liver were introduced intravenously into partially hepatectomized (resection of 2/3 or 1/4 of liver) syngeneic recipients. Cells of regenerating spleen sharply inhibited the mitotic activity of cells of the recipient liver following resection of 1/4 of liver 48 h after the operation and introduction of cells. Inhibition proved to be dose-dependent: it became apparent when 30 million cells were introduced, increased at a dose of 60 million cells and remained at the same level at higher doses. Division of hepatocytes after resection of 1/4 of liver was inhibited by spleen cells taken in the donors 36 h after partial hepatectomy. Spleen cells of intact and pseudo-operated donors had no such ability. Introduction of 60 million of cells of the regenerating spleen and of the spleen of partially hepatectomized animals into recipients with resection of 2/3 of liver did not inhibit reliably the division of hepatocytes, thus indicating the dependence of inhibition on the level of suppressors in the organism. Resection of a major part of liver was accompanied by a greater decrease in the activity of endogenous suppressors which could not be recovered by the introduced cells. Inhibition of cell division by suppressors was not organ specific. Suppressors inhibited proliferation in liver irrespective of the site of operation.

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[Antibody formation in experimental kidney failure and in the early stages of restorative kidney growth in mice].

The ability of spleen cells to respond with antibody formation to a foreign antigen (sheep erythrocytes) was studied in mice at different kidney lesions (uni- and bilateral nephrectomy, ureter ligation, pseudo-operation, wound of one kidney) during the early postoperation period (1-72 h). In the case of bilateral nephrectomy, the reliable increase in the number of antibody-forming cells (AFC) was noted already within 1 h after the operation, in the case of unilateral nephrectomy within 12 h. In the case of bi- and unilateral ligations of ureter, the response was delayed by 3 and 5 h, respectively. Sham operation and kidney wound did not stimulate antibody formation. It is suggested that the antibody-forming ability of the spleen cells does not depend on stress, renal deficiency or destructive changes and that the antibody formation is activated by disturbances in the ratio of immunoregulatory cells.

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[Changes in the nature of the differentiation of the erythroid stem cell in the bone marrow of mice as affected by the peritoneal cells of donors subjected to bloodletting].

The influence of the peritoneal cells unstimulated by an inflammatory agent (PCs) on the bone marrow erythropoiesis in the CBA mice was studied in the normal conditions and after the massive haemorrhage. The PCs obtained from the intact or anemic donors (2, 4 and 18 h after the haemorrhage) were introduced intraperitoneally into the intact syngeneic recipients. The massive haemorrhage induces a special type of differentiation of erythroid cells in bone marrow, "reserve erythropoiesis", which is characterized by a decrease, within four days, in the proliferation of basophilic proerythrocytes, stimulation of proliferation of polychromatophilic proerythrocytes and entry of oxyphilic proerythrocytes into mitosis. The transplantation of the PCs from the anemic donors induced the "reserve erythropoiesis" in the bone marrow of the recipients. The transplantation of the PCs from the intact donors did not induce the "reserve erythropoiesis" and appeared to inhibit erythropoiesis via lengthening the time of mitoses in polychromatophilic and basophilic proerythrocytes.

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[Reactive changes of the thymus and spleen in response to surgical intervention].

Histostructure of the thymus and spleen was studied after a sham operation, unilateral nephrectomy and 2/3 hepatectomy. The alterations observed corresponded to those in stress. The differences were seen in intensity and changes in the spleen periarterial zones. These zones were wasted 4-72 hours after the sham operation while their cellularity was increasing after nephrectomy and hepatectomy. The structure of the thymus got partially restored by day 5-7, while blast transformation and plasmatization of splenic cells was not yet completed.

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[Kinetics of lymphoid cell subpopulations in the mouse spleen in the early period after unilateral nephrectomy].

The content of total T- and B-lymphocytes, T-rosette-forming at 37 degrees, T-autorosette-forming (ARF), FcIgM+, FcIgG+ and TDT+ lymphocytes is determined in mice after unilateral nephrectomy. The number of ARF, FcIgM+ and TDT+ lymphocytes increased 17 and 48 hours after the nephrectomy. The coincidence in time of the lymphocyte population increase with acquisition of morphogenetic activity by the spleen lymphoid cells allows one to assume their participation in the regenerative proliferation of renal epithelium. The alterations in the content of other lymphocyte populations were in the limit of random deviations.

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[Morphological equivalents of lymphocytic-epithelial interactions in kidney and liver regeneration].

The histo- and ultrastructure of the murine kidney and liver is studied 17 and 48 h, respectively, after unilateral nephrectomy or partial hepatectomy. The number of lymphocytes are found to be increased in these organs after the operation. They come in close contact with hepatocytes and renal tubular epithelial cells forming in some cases gap junctions. It occurs more often 48 h after operation. The number of leukocytes is found to be increased also especially in the regenerating liver in which many hepatocytes with cytoplasm partial necrosis are found. Only single epithelial cells are involved in the destruction in the kidney. Possibility of lymphocyte participation in the morphogenetic function realization is discussed.

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