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Biomedical subjects

A G Babaeva

Publications and source records attributed to A G Babaeva.

At least 37 records · Page 2Linked to original sources

[Intensified capacity of the lymphocytes of mice with repeated liver resection to transfer "regenerative information"].

It has been found that after extirpation of one liver lobe the lymphocytes of CBA mice did not stimulate the mitotic activity in the liver cells of non-operated syngeneic recipients. On the other hand, following single extirpation of 2/3 of the liver and after two-stage (with a 20-day break) removal of 2 liver lobes, mouse lymphocytes significantly stimulated the proliferative activity in the recipients' hepatocytes and Kupffer cells. The stimulation was organ-specific, since there was no variation in the mitotic index of renal cells in the experimental groups compared with controls. These data agree with the concept of the immune character of the capacity of lymphocytes to transfer "regenerative information".

Animals↗

[Stimulation of the mitotic activity of hepatocytes and Kupffer cells in the liver of nonoperated mice by T and B lymphocytes from partially hepatectomized syngeneic donors].

T lymphocytes from the spleen of partially hepatectomized CBA mice enhance the mitotic activity of hepatocytes and Kupffer cells of the liver in nonoperated recipients. The proliferation induced by these cells is equal to the inductive capacity of the whole suspension of lymphocytes from the spleen of partially hepatectomized animals, which contains T and B lymphocytes. The proliferation induced by B lymphocytes from the spleen of operated mice is significantly lowered and is displayed chiefly in relation to Kupffer cells.

Animals↗

[Change in the resistance of partially hepatectomized mice to transplanted tumors in the period of liver regeneration completion].

There were two inhibition periods of the growth of ascitic hepatoma 22a when its cells were transplanted intraperitoneally to partially hepatectomized A/he mice 1 to 12 days after the operation. The first inhibition took place when the transplantation was performed one day, and the second--3 to 10 days, after partial hepatectomy. The animals which were most resistant to this tumour (5 to 8 days after the operation) proved to be resistant, although to a lesser extent, to the intraperitoneal transplantation of sarcoma 37 and Ehrlich's adenocarcinoma.

Animals↗

[Repeated amputation of the lower incisors in rats and the phenomena of salivary gland and testicular hypertrophy].

Repeated amputation of the lower incisors in rats, 11- and 14-days old, caused hypertrophy of the testis only in the presence of the submaxillary salivary glands. Bilateral submaxillary and sublingual sialadenectomy prevented hypertrophy of the testis. After the unilateral removal of these glands the weight of the testis increased, but its hypertrophy developed always. The absence of hypertrophy of the testis in the sialadenectomized animals led to the conclusion that the growth stimulating action on the testis of repeated amputations of the lower incisors was in some way mediated through the function of the salivary glands.

Animals↗

[Genetic differences in lymphoid tissue reactivity during liver regeneration in mice of different lines].

The transfer of lymphocytes together with sheep erythrocytes from partially hepatectomized mice to syngenous lethally irradiated mice (CAB and C57BL) increased the number of antibody forming cells in the recipient's spleen. The lymphocytes of CBA mice acquired this ability much earlier after the operation (in 4 hours) than those of the C57BL mice (in 17 hours). After the transfer of lymphocytes in the semisyngenous system there was a decrease of antibody forming cells during subsequent recipient's immunization with sheep erythrocytes; this was the result of the graft versus host reaction. The latter reaction was less marked in the operated than in control mice. These changes also occurred earlier after the operation in the CBA than in C57BL mice.

Animals↗

[Phenomenon of hypertrophy of the testes after amputation of the lower incisors in rats].

Repeated amputation of the lower incisors in rats carried out at the early postnatal on togenesis causes an enlargement of the salivary glands and hypertrophy of the testis with the phenomena of acceleration of their differentiation. Hypertrophy of the testes withthe mentioned action was much greater (76%) than in the case of unilateral castration at the same age. In adult animals repeated amputation of the lower incisors caused hypertrophy of the salivary glands, but failed to influence the hypertrophy of the testes.

Age Factors↗