Biomedical subjects

A Furuse

Publications and source records attributed to A Furuse.

At least 163 records · Page 9Linked to original sources

PubMed1990

[Effect of superoxide dismutase on serum sickness nephritis].

Antiinflammatory effect of recombinant human Cu, Zn superoxide dismutase (SOD) was studied in Wistar rats with serum sickness nephritis induced by egg albumin injection. Different dosages of SOD were given intramuscularly in nephritis rats as follows: 0 (group A), 2 (group B), 10 mg/kg/day (group C). Control rats were given 10 mg/kg/day of SOD. On day 52, histopathological examinations of the kidney were performed in all animals. Urinary albumin was 0.35 +/- 0.21, 0.24 +/- 0.14, 0.34 +/- 0.28 and 0.41 +/- 0.21 mg/day in group A, B, C and control, respectively on day 0, and 33.0 +/- 21.5, 1.52 +/- 0.54, 2.55 +/- 1.67 and 0.21 +/- 0.02 mg/day in group A, B, C and control, respectively on day 52. Daily administration of SOD significantly suppressed urinary albumin excretion (A vs B & C, P less than 0.05). Numbers of nucleus per one glomeruli in rats were 119 +/- 3.6, 76.3 +/- 6.7, 71.1 +/- 8 and 65.5 +/- 3.3 in group A, B, C and control, respectively (A vs B & C, p less than 0.01). The glomerular damage in serum sickness nephritis which was potentially induced by free oxygen radicals, would be prevented by the administration of SOD.

Albuminuria↗

PubMed1990

Rotation-advancement flap method for correction of partial anomalous pulmonary venous drainage into the superior vena cava.

Three patients with partial anomalous pulmonary venous drainage into the superior vena cava underwent repair by a rotation-advancement flap method. The technique consisted of atrial partitioning, enlargement of the superior vena cava, and protection of sinus node function. Follow-up studies of all patients were done between 12 and 15 months after the operation. The superior vena cava was not stenosed and its diameter was normal, as demonstrated by cavograms. Pulmonary venous return appeared normal on angiograms, and sinus node function was normal by electrophysiologic studies.

Adult↗

PubMed1990

[Hamilton's operation in Bland-White-Garland syndrome].

A 14-year-old boy, who had been treated medically for mitral regurgitation, underwent cardiac catheterization which revealed not only mitral regurgitation but also anomalous origin of the left coronary artery from the pulmonary artery. Thus he was diagnosed as Bland-White-Garland syndrome which was repaired by Hamilton's operation. Under cardiopulmonary bypass, the pulmonary trunk was opened longitudinally. After aorto-pulmonary window (A-P window) was created, a heterogenous pericardial baffle was attached to the posterior wall of the pulmonary trunk connecting A-P window and the ostium of left coronary artery. Thereafter the pulmonary trunk was enlarged with a patch of the same material. He did well postoperatively. Postoperative angiogram demonstrated satisfactory reconstruction of two-coronary-artery system.

Adolescent↗

PubMed1990

[Oxygen uptake during exercise before and after cardiac valve surgery: anaerobic threshold and maximal oxygen uptake].

Exercise stress tests with bicycle ergometer were performed before and after surgery in 14 patients with valvular heart diseases. Aortic valve replacements were performed in two patients, open mitral commissurotomy in two, mitral valve replacement in eight and combined valvular procedure in two. All patients except one showed improved NYHA function class after the surgery. Oxygen uptake was assessed at anaerobic threshold and peak achieved workload. One patients who failed to increase his heart rates during exercise both before and after surgery revealed unchanged NYHA function class and decreased oxygen uptake postoperatively. The other patients showed statistically significant increases of oxygen uptake not only at anaerobic threshold but also at peak achieved workload. At anaerobic threshold, oxygen uptake was 0.92 + 0.14 l/min before surgery and 1.09 + 0.22 l/min after surgery. Maximal oxygen uptake increased from 1.11 + 0.27 l/min to 1.47 + 0.36 l/min postoperatively. Heart rates at anaerobic threshold and at peak workload showed no significant differences. Postoperative increases of oxygen uptake was achieved by the increases of oxygen pulses, which was considered to be from the increases of stroke volumes.

Anaerobic Threshold↗

PubMed1990

[Quadricuspid aortic valve: case reports].

Two cases of quadricuspid aortic valve with aortic regurgitation are reported. Case 1, a 66-year-old woman was operated on because of aortic regurgitation, and an aortic valve replacement with a bioprosthesis was performed. When the valve was exposed during the operation, it showed four cusps, three of which were of equal size and one smaller cusp which was interposed between the right and left coronary cusp. Case 2, a 46-year-old man was diagnosed, using echocardiography and aortography before surgery, as suffering from aortic regurgitation because of a quadricuspid aortic valve. During surgery, two larger cusps and two smaller cusps and a displacement of the right coronary artery ostium, (which was placed in a lower position and close to the commissure between the right coronary and the right posterior cusps) were found. The four cusps were excised and replaced by a tilting disc prosthesis. In both cases, the postoperative recovery was uneventful. Using the 24 cases from the literature and two of our own cases, the correlation between the size or the position of the accessory cusp and the occurrence of aortic regurgitation was analyzed. The larger the accessory cusp was, the higher the incidence of aortic regurgitation occurred (p less than 0.05).

Aged↗

PubMed1989

Renal tubular differentiation in mouse and mouse metanephric culture. I. Ultrastructural studies.

We studied the morphologic features of renal tubular differentiation in transfilter metanephric culture. Differentiation of portions of the S-shaped loop into proximal convoluted tubule was detected shortly after 72 h of culture by the appearance of microvilli, coated membrane invaginations, and an apical vacuolar-microtubular network. These features developed synchronously, and the microvilli became progressively more numerous and more compact to form a brush border. Computer-assisted morphometric analysis showed only minor differences between proximal tubular cells from 18-day embryos and tubular cells from 7-day cultures of blastema taken from 11-day embryos. Segments of tubule corresponding to distal convoluted tubules were lined with relatively simple cells that contained few differentiating characteristics. Morphometric modeling of the tubular cells indicated a simple shape consistent with an inherent transport function.

Animals↗

PubMed1989

Renal tubular differentiation in mouse and mouse metanephric culture. II. Na-K-ATPase activity.

Sodium-potassium adenosine triphosphatase (Na-K-ATPase) activity was measured by microassay, and the surface density of basolateral membranes was measured morphometrically in postglomerular segments of single tubules isolated from normally developing, intact mouse kidneys and from transfilter metanephric cultures. Proximal tubule Na-K-ATPase activity was 1092 +/- 480 pmol/mm per hour in newborn mice, increasing to 2462 +/- 258 in 1-week-old and 3470 +/- 578 pmol/mm per hour in adult mice. The Na-K-ATPase activity in newborn mice was approximately one-third of the activity in adult mice. Tubular Na-K-ATPase in transfilter metanephric culture was 972 +/- 536 pmol/mm per hour, a mean value almost identical to that in newborn mice. The surface density of basolateral cell membranes was 1.36 +/- 0.60 microns2/microns3 in newborn mice and 1.34 +/- 0.45 microns2/microns3 in 1-week-old mice, increasing to 2.70 +/- 0.98 microns2/microns3 in 4-week-old mice and 2.89 +/- 0.51 microns2/microns3 in adult mice. The surface density of tubular basolateral cell membranes in transfilter metanephric culture was 1.13 +/- 0.51 microns2/microns3, not significantly different from the surface density in newborn mice. The calculated mean surface area of basolateral membranes per unit tubular length was greater in cultures than in newborns, however, because total epithelial volume per unit length was significantly larger in the cultured tubules. Membrane surface area in intact mice increased with age, the surface area per unit length of tubule in adults being 4.6 times the area in newborn animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗

PubMed1989

Effects of aldosterone and betamethasone on Na-K-ATPase activity in the juxtamedullary proximal convoluted tubules of mice.

An attempt was made to determine whether or not the steroid hormones, aldosterone and betamethasone, increased the Na-K-ATPase activity and the surface density of baso-lateral cell membranes in the juxtamedullary proximal convoluted tubules of young and adult mice. The results showed that aldosterone and betamethasone increase the enzyme activity in young mice but not in adult mice. However, the surface density of the baso-lateral cell membranes did not increase either in the young or in the adult mice. Further, the induction ratio for the Na-K-ATPase activity did not differ between the two hormone-treated groups in young mice. The results suggest that a difference in hormone sensitivity exists between the proximal convoluted tubular cells of young mice and those of adult mice.

Aldosterone↗

PubMed1989

[Roentogenologic pathologic evaluation of allograft rejection in heart-lung transplantation--an experimental study in Japanese monkey].

Experimental heart-lung transplantation was carried out in Japanese Monkey (Macaca fuscata). Twelve monkeys survived two to thirty-three days. Pathologic examination of the lung was performed at the time of open lung biopsy and autopsy. Postoperative chest roentogenogram was also studied in seven monkeys. In the early postoperative period, central cloudiness and enhancement of the interstitial change were observed, which started from the second or third postoperative day and reached their peak between the fifth and eighth postoperative day. Pathological study revealed no obvious monocyte infiltration in the lung of this stage. Two types of pulmonary rejection were observed, one is alveolar and vascular rejection. The other is vascular type of rejection, which started as early as in the twelfth postoperative day in a case. In the former, consolidation of the lung was noticed and useful in the diagnosis, but in the latter, no distinct change was observed in plain chest roentogenogram.

Animals↗

PubMed1989

[A case of metastatic lung tumor of the colon cancer with ova of schistosoma japonicum in the resected lung specimen].

A 69-year-old man underwent right middle lobectomy because of the tumor lesion in the right middle lung. He had ever been in Celebes and China (riverside area of the Yangtze), the infected area of schistosomiasis japonica, for military service during the World War II. Resected lung specimen was carefully examined at the department of pathology in our hospital. Several ova of Schistosoma japonicum were discovered scattered in the specimen, and the pathological feature of the lung lesion was revealed to be metastasis of the sigmoid colon cancer which was resected 4 years ago at a certain hospital. The ova of Schistosoma japonicum were also distributed near the colon lesion. Recently in Japan, it is said, acute infected case of schistosomiasis japonica has been ceased, however, in cases of chronic stage of this disease, hepatoma or lower intestinal cancers are still discovered through the careful follow up study.

Adenocarcinoma, Papillary↗

PubMed1989

[Modified mitral valve replacement with preservation of chordae tendinae].

The purpose of leaving the mitral apparatus in place during mitral valve replacement is twofold. One is to preserve ventricular performance and another is to prevent ventricular rupture. Our clinical results of modified mitral valve replacement were compared with those of conventional mitral valve replacement. The analysis was done to see if any difference existed between patients predominantly with mitral stenosis and with regurgitation. Hospital mortality of the modified group was significantly less than that of the conventional group. In mitral stenosis, this was due to the disappearance of ventricular rupture. In mitral regurgitation, on the other hand, this was mostly due to the decrease of low output-multi-organ failure syndrome. Ventricular function was assessed by echocardiography up to 3 years postoperatively. The superiority of ventricular performance in modified technique was prominent in the subgroup of mitral regurgitation.

Chordae Tendineae↗

PubMed1989

[Respiratory failure after thymectomy in myasthenia gravis: evaluation of preoperative influencing factors and preventive managements against postoperative respiratory dysfunction].

Postoperative respiratory function was evaluated in 94 patients with myasthenia gravis after thymectomy. Preoperative clinical and pulmonary function data were submitted to statistical analyses. The duration of respiratory support and intratracheal intubation time were significantly correlated to % vital capacity, the clinical stage of myasthenia gravis, and the clinical stage of thymoma. Statistical analyses proved that anticholinesterase drugs taken in immediate postoperative period contributed to the improvement of postoperative respiratory function, and non-depolarizing muscle relaxants, i.e. d-tubocurarine which had been considered to be contraindicated in myasthenia gravis was found to be beneficial immediately after the operation in patients with severely deteriorated respiratory function preoperatively.

Cholinesterase Inhibitors↗

PubMed1989

[Anaerobic threshold and oxygen uptake in patients with mitral stenosis].

The exercise stress test with a bicycle ergometer was performed for 31 patients with mitral stenosis and for 10 normal subjects. The patients were categorized in two groups. Group 1 consisted of 16 patients having indication for surgical intervention and Group 2 consisted of 15 patients without such surgical indications. Oxygen uptakes at the anaerobic threshold and at peak exercise (MAX) were assessed by percent attainment of the predicted normal value from Posner's equation. Heart rates during exercise did not differ between the two groups. However, Group 1 had significantly smaller values of percent attainment of oxygen uptake both at the anerobic threshold and peak exercise than the controls and Group 2. Oxygen pulses in Group 1 were also significantly less than in the controls or Group 2. Seven cases were reassessed six months or more after surgery including open mitral commissurotomy in two and mitral valve replacements in five. The improvement of oxygen pulse showed a statistical significance. Percent oxygen uptake attainment was also significantly improved both at the anaerobic threshold and at peak exercise. Percent attainment of oxygen uptake in mitral stenosis differed significantly according to the NYHA class both at the anaerobic threshold and peak exercise. These values are considered useful for making decisions for surgical treatment in borderline cases.

Adult↗

PubMed1989

[Mitral valve prolapse in patients with surgically-closed atrial septal defect].

To evaluate the prevalence, causes and clinical significance of mitral valve prolapse (MVP) associated with surgically-closed atrial septal defect (ASD), 90 patients (M: 41, F: 49) were studied using two-dimensional and color-coded Doppler echocardiography. Among the 90 patients, preoperative echocardiograms were available in 27. MVP was found in 21 of the 27 patients (78%) preoperatively, but it was found in 59% (16/27) postoperatively. In total, MVP was detected in 50 of the 90 patients (56%) postoperatively. The postoperative MVP group had higher pulmonary-to-systemic flow ratios (3.6 +/- 1.9 vs 2.8 +/- 1.1, p less than 0.05) and higher mean pulmonary arterial pressures (21 +/- 11 vs 13 +/- 5 mmHg, p less than 0.01) at the time of surgery. Between the two groups with or without MVP postoperatively, there was no difference (p less than 0.05) in age at surgery, the postoperative duration and left ventricular (LV) deformity index both in pre- and postoperative states. A mitral regurgitant (MR) murmur was recorded in seven patients postoperatively. However, only two had clinically severe MR. It was concluded that MVP is frequently detected in patients with closure of ASD and it is related neither to degree of the LV deformity nor to age at operation; rather, it is related to the severity of the preoperative hemodynamic state. Clinically significant MR is rare in the postoperative period.

Adolescent↗

PubMed1989

[Double orifice mitral valve associated with bicuspid aortic valve].

A 63-year-old man with double orifice mitral valve (DOMV) and bicuspid aortic valve was reported. Preoperative echocardiography showed prolapse of the posterior leaflet and mitral regurgitation but was unable to show the existence of the duplication of the mitral valve. He underwent aortic and mitral valve replacement and did well after surgery. DOMV is a rare congenital malformation, and DOMV associated with bicuspid aortic valve is the first reported case in Japan.

Abnormalities, Multiple↗

PubMed1989

[Evaluation of antiplatelet drugs on platelet functions--comparison between ticlopidine and dipyridamole after prosthetic valve replacement].

We examined the efficacy of antiplatelet drugs after prosthetic valve replacement. As an early postoperative group (group E), 49 patients were divided into four groups. In group A only warfarin was given. In group B warfarin and dipyridamole 300 mg/day, in group C warfarin and ticlopidine 300 mg/day, in group D warfarin and ticlopidine 600 mg/day were administered respectively. As a late postoperative group (group L), 45 patients with prosthetic valves were divided into two groups. In group I dipyridamole 300 mg/day in group II ticlopidine 300 mg/day were administered. Both group I and II received warfarin. In group E platelet counts and platelet aggregability were examined to 22 POD. In group L starting two years after valve replacement, platelet counts were examined eight times by three-month intervals, and platelet aggregability, platelet adhesiveness were investigated 36 months in group I and 27 months in group II postoperatively. Results are the following. 1) Neither ticlopidine nor dipyridamole had any effects on the platelet counts through the postoperative period. 2) In the early postoperative period, the administration of antiplatelet drugs to groups B, C, and D suppressed platelet aggregability more than group A. 3) Ticlopidine (groups C and II) reduced ADP and collagen aggregabilities compared with dipyridamole (group B and I) both in the early and late postoperative period. 4) Ticlopidine 300 mg/day (group C) and ticlopidine 600 mg/day (group D) had no difference in ADP and Collagen aggregabilities. 5) No significant difference was shown between dipyridamole (group I) and ticlopidine (group II) in platelet adhesiveness.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1989

[Cardiac operation in children of Jehovah's Witnesses].

The perioperative courses of 5 open heart operations in children of Jehovah's Witnesses are reviewed. The age of patients ranged from 6 to 13 years old and the body weight, from 21.5 kg to 38.5 kg. All the patients survived and are doing well now. The cardiopulmonary bypasses, primed with lactated Ringer's solution, were performed safely with the use of moderate hypothermia. Hemodilution techniques are the key for the safe exocorporeal circulation and we set the lowest limit of body weight at 20 kg. Postoperative bleeding occurred in one case and was treated by early exploration. All the cases did not receive any blood or blood products during hospitalization. Therefore we can conclude that cardiac operations over 20 kg of body weight can be safely performed without any blood or blood products. With regard to social aspects, especially in case of emergency, we should make the decision regarding transfusion under the guidance proposed by the Japanese Medical Association.

Adolescent↗

PubMed1989

[Combined aortic and mitral valve replacement with or without preservation of posterior mitral apparatus].

Seventy patients who underwent aortic and mitral valve replacement were reviewed. 37 patients had the mitral valve replaced with preservation of posterior mitral apparatus (AVR and modified MVR; modified group), and the others without (AVR and conventional MVR; conventional group). Hospital deaths occurred in 4 patients (12.1%) in conventional group and in only 1 patient (2.7%) in modified group. Four out of these five hospital deaths were due to low output syndrome (LOS). The other one died of unknown cause. Severe LOS, necessitating intra-aortic balloon pumping, occurred in 4 (12.1%) in conventional group and in 2 (5.4%) in modified group. In the early postoperative period modified group showed better left ventricular function than conventional group in terms of cardiac index and left ventricular stroke work index. Cardiac performance was evaluated by means of echocardiography at the time of discharge. Modified group showed better fractional shortening and shorter PEP/ET (pre-ejection period/ejection time). These findings suggest that the lower mortality of modified group is due to better left ventricular function preventing LOS in the early postoperative period, and that preserving the posterior mitral apparatus has a more beneficial effect on postoperative left ventricular function even in combined valve disease.

Aged↗