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Biomedical subjects

A Furuse

Publications and source records attributed to A Furuse.

At least 181 records · Page 10Linked to original sources
PubMed1989

[The role of interleukin-2 in the impaired lymphocyte function after open heart surgery].

To reveal the mechanism of impaired lymphocyte function shown as the suppression of mitogenic proliferation of lymphocytes after open heart surgery, we evaluated the kinetics of Interleukin 2 (IL-2) production and response of lymphocytes sequentially until 7th day postoperatively in 10 patients. Membrane oxygenators were used exclusively and steroids were not administered during this study. In addition to the assay of mitogenic response (PHA), we measured IL-2 production and response utilizing IL-2 dependent cytotoxic T cell line and mitogenic proliferation to standard IL-2 respectively concomitant with plasma cortisol level. The results are as follows. 1. Mitogenic proliferation was suppressed with significance postoperatively (1POD: p less than 0.01). 2. IL-2 production was suppressed with significance postoperatively (3POD: p less than 0.05). In contrast no significant fluctuation of IL-2 responsiveness was observed postoperatively. 3. No correlation between plasma cortisol levels and these impairment was shown in this study. In conclusion impaired IL-2 production might be responsible for deficient lymphocyte function after open heart surgery.

Adult↗
PubMed1989

[Rastelli's procedure].

In 1969, Rastelli conceived a new technique to repair of transposition of the great arteries in the presence of ventricular septal defect and severe pulmonary stenosis (TGA III), based on the redirection of ventricular outflows. An intracardiac tunnel connected the left ventricle to the aorta and an external valved conduit established continuity between the right ventricle and the pulmonary artery. TGA III and truncus arteriosus are underwent a Rastelli operation. The present report is an analysis of indication, operative technique, early and late results with this procedure. Early deaths were related to unfavourable anatomy, conduit compression and sepsis. Residual VSD and postoperative infection were the main factors contributing to the late deaths. A current Re-Rastelli operation for the problems of extracardiac valved conduit is a good result.

Humans↗
PubMed1988

Doppler analysis of flow velocity profile at the aortic root.

This study of aortic root flow velocity profiles suggests that the flow velocity pattern is parabolic rather than flat as has been widely supposed. To analyze the distribution of flow velocity, a special ultrasound pulsed Doppler velocity flow meter, with a direct probe on the aortic wall, was designed. Sixteen patients, none with a diagnosis of aortic valve disease, were examined just before undergoing open heart surgery. Parabolic velocity patterns were always found, and it was determined that the parabola was skewed rightward toward the anterior wall. Furthermore, it was shown that the flow velocity vector was initially directed toward the commissure of the right coronary and the noncoronary cusps.

Adult↗
PubMed1988

Presence of HBe antibody in glomerular deposits in membranous glomerulonephritis is associated with hepatitis B virus infection.

The specificity of IgG on the glomerular capillary wall was investigated in 3 patients with hepatitis B virus associated membranous glomerulonephritis. The immune deposits on the capillary walls were stained by immunofluorescent antibody against HBe antigen and IgG. The eluted fluid (0.02 M citrate buffer, pH 3.2) from renal biopsy slices contained significant activity of HBe antibody, but not of HBs and HBc antibodies. After elution, the disappearance of IgG on the capillary walls was confirmed by immunofluorescence. Heterologous complement activation with fresh guinea pig complement was positive in the glomerular capillary walls from all 3 patients. Our observations support the notion that this disease is caused by HBe antigen-anti-HBe immune complexes.

Antigen-Antibody Complex↗
PubMed1988

[Current status of cardiac surgery in the elderly].

Current status of cardiac surgery in the elderly is described. Coronary artery bypass grafting or uncomplicated valve replacement can be safely performed in the septuagenarian. Ventricular septal rupture has been successfully repaired in the octogenarian. Atrial septal defect in the sexagenarian can be closed without complication. Late results of pacemaker implanted in the octogenarian have been as good as in the sexagenarian.

Aged↗
PubMed1987

Percutaneous coronary angioscopy in patients with ischemic heart disease.

Percutaneous transluminal coronary angioscopy was performed during routine coronary angiography in seven patients and during PTCA in one patient with ischemic heart disease. A flexible fiberscope with an external diameter of 1.4 mm was introduced through an 8F or 9F guiding catheter used for PTCA into the coronary arteries. Warmed saline solution (15 to 20 ml) was injected through the guiding catheter into the coronary arteries for replacement of blood. Twenty-one of the 31 coronary segments were visualized and photographed on color cinefilms. The lumen of the atherosclerotic segment showed narrowing with smooth surface or with spiral folds. PTCA caused dilatation of the stenosed segment with scattered thin thrombi. These findings indicate the usefulness of angioscopy to observe luminal changes in the coronary arteries of patients with ischemic heart disease.

Aged↗
PubMed1987

The effect of cardiopulmonary bypass on T cells and their subpopulations.

To investigate the effect of cardiopulmonary bypass (CPB) on T cells, lymphocyte subsets of peripheral blood and lymphoid organs were monitored during and after open-heart surgery (Group 1). As a control, lymphocyte subsets of peripheral blood were measured in patients undergoing thoracovascular operations without CPB (Group 2). In Group 1, analysis of each subset-to-total lymphocyte ratio revealed that observed lymphocytopenia in the early postoperative days was mainly the result of T cell reduction, and that the decrease of helper/inducer T cells contributed to this decrease. In contrast, no significant fluctuation of any lymphocyte subpopulation ratio was observed in Group 2. Analysis of lymphocyte subpopulation ratios in lymphoid organs showed that reciprocal changes of T cells and their subsets were observed in the bone marrow, thus indicating that the redistribution of T cells (especially of helper/inducer cells) seems to occur between peripheral blood and bone marrow in Group 1. Furthermore, there was no relationship between serum cortisol levels and the changes in lymphocyte subset ratios in Group 1 patients.

B-Lymphocytes↗
PubMed1987

Techniques of modified mitral valve replacement with preservation of the posterior leaflet and chordae tendineae.

Modified mitral valve replacement (MVR) was performed mostly with mechanical valves in 117 patients consisting of 53 patients with mitral regurgitation (MR) and 64 patients with mitral stenosis (MS) or combined mitral valve disease (MSR). Concomitantly, aortic valve replacement (AVR) was carried out in 42 patients, tricuspid annuloplasty (TAP) in 26, tricuspid valve replacement (TVR) in 2 and other procedures in 4. There were 3 hospital deaths and 3 late deaths. In this series, 4 types of technique were utilized in order to preserve the posterior leaflet and chordae tendineae. The authors recommend the following techniques. In pure or predominant MS, after removal of the anterior leaflet and chordae, buttress sutures are placed from the valvular annulus to the posterior leaflet near its free margin. In pure or predominant MR, excising part of the posterior leaflet is added prior to the above-described technique. By using these two techniques, modified MVR can be performed for any type of valve lesion and with any kind of prosthetic valve.

Adolescent↗
PubMed1987

Postinflammatory mitral and aortic valve prolapse: a clinical and pathological study.

In this study we reevaluated whether the sole cause of mitral valve prolapse (MVP) and aortic valve prolapse (AVP) is myxomatous degeneration. Forty-two surgical cases of prolapsed valves with mitral and/or aortic regurgitation were reviewed (AVP in nine, MVP in 27, and combined AVP and MVP [CVP] in six). On microscopic examination, myxomatous degeneration was observed in 20 patients, including six with AVP, 13 with MVP, and one with CVP. In the other 22 patients, including three with AVP, 14 with MVP, and five with CVP, microscopic examination revealed fibrosis with vascularization and scattered infiltration of inflammatory round cells caused by postinflammatory changes with or without chronic inflammation. We coined the term "postinflammatory valve prolapse" (PIVP) to describe these valves. Both postinflammatory and myxomatous degeneration were observed in seven patients with floppy mitral valves attributable to PIVP. Rupture of chordae tendineae was present in six patients with myxomatous mitral valve and three with PIVP. Seven patients with PIVP had a history of rheumatic fever. The results suggest that valvular prolapse is produced not only by myxomatous degeneration but also by postinflammatory changes, including those caused by rheumatic fever.

Adult↗
PubMed1987

Surgical consideration of replacement of the ascending aorta and aortic valve with a composite valve graft--operative and long-term results of Bentall and DeBono procedure.

Our experience with the Bentall and DeBono procedure is reviewed. Between April, 1977 and April, 1985, seventeen patients underwent repair of annulo-aortic ectasia (9 cases), and dissecting aneurysm with aortic regurgitation (8 cases). Three patients had cardiac tamponade due to rupture of dissecting aneurysm. In regard to this procedure, we recently performed the continuous suture method on the prosthetic valve ring, coronary ostia, and distal anastomosis sites. In this study, there was one early death due to a sudden rupture of the dissecting aneurysm of the left thoracic cavity on the 10th postoperative day. In addition, there were two late deaths due to sepsis and suspected arrhythmia. The late follow-up period ranged from 6 months to 8 years (mean 35 months), and all patients were in NYHA Class I or II. We conclude that the composite valve graft method is an excellent technique for annuloaortic ectasia and ascending aortic dissections with aortic regurgitation because of its low operative mortality and fair survival rate.

Adult↗