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A Fox

Publications and source records attributed to A Fox.

204 records · Page 12Linked to original sources

Determination of ivermectin in medicated swine feeds at the 2 ppm concentration level.

An analytical method has been developed that is applicable to the determination of Ivermectin in medicated feeds at the 2 ppm concentration level. It is based upon liquid chromatographic analysis with a reverse-phase column and ultraviolet detection. After the drug is extracted from the feed into methanol, an analytical sample is prepared by the consecutive use of column chromatography on alumina and solid-phase extraction on Sep-Pak C18 and silica cartridges. This procedure has been applied to the concentration range 0.50-3.0 ppm of Ivermectin in feed with an accuracy of +/- 2% mean relative error and a precision of +/- 2% relative standard deviation at the 2 ppm concentration level.

Animal Feed↗

Giant unclippable aneurysms: treatment with detachable balloons.

Nine cases of giant unclippable aneurysms treated with the detachable balloon technique are reported. Adjunctive surgical bypass procedures and arterial ligation were also carried out in four and one cases, respectively. All the patients tolerated occlusion of the carotid artery (eight cases) or of both vertebral arteries (one case). Three patients developed neurologic complications: two transient and one permanent (blindness in one eye). The complications occurred when attempts were made to occlude the aneurysm lumen only to preserve the carotid blood flow. Permanent occlusion of the carotid artery appears safer than aneurysm obliteration. Surgical procedures are necessary if the patient does not tolerate permanent occlusion of the artery or if occlusion of the artery is insufficient to obtain thrombosis of the aneurysm.

Adolescent↗

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Adult↗

Liquid chromatographic determination of ivermectin in feed.

An analytical method for determining ivermectin in feed at 0.50-3 ppm is presented. The method is based on liquid chromatographic measurement after sample preparation by adsorption chromatography on alumina and solid-phase extraction. Two complete, final, finished medicated feeds and the corresponding control feeds used in their preparation were analyzed. Recoveries from feeds fortified at 50-150% of the 2 ppm ivermectin use concentration also were determined. Mean recoveries from replicate analyses ranged from 90 to 100%, and coefficients of variation (CVs) were less than 4.5%. No significant interferences were found in control feeds. The pooled distribution of individual analytical results (n = 100) gave a mean recovery of 100%, a recovery range of 90-111%, and an overall CV of 5.5%. Resolution of the total variance into its 2 components gave a within-laboratory CV of 4.1% and a between-laboratory CV of 3.4%. There was no significant difference in recoveries among laboratories, days, concentrations, and feed base or between fortified and medicated feeds (P > 0.2).

Animal Feed↗