Biomedical subjects
Publications and source records attributed to A Ferlito.
A case of metastases from laryngeal cancer to cervical lymph nodes involved also by chronic lymphocytic leukaemia is reported. The simultaneous presence of the two lesions in four lymph nodes is documented histologically. To the best of the authors' knowledge, no similar case can be found in the literature.
A case of leishmaniasis of the larynx caused by Leishmania donovani occurring in a 42-year-old man is reported. The oral cavity and the upper respiratory tract are commonly involved in mucocutaneous American leishmaniasis, but are less frequently reported in the 'Old World'. The primary and isolated location in the larynx is exceptional. The immunoperoxidase technique using antisera to anti-L. donovani is a useful method to identify the parasite.
The clinical and pathological findings in 4 cases of primary giant cell carcinoma of the larynx are reported. This variant of large cell carcinoma resembles the well-defined giant cell carcinoma of the lung. It has to be distinguished from other types of carcinoma of the larynx. This can be difficult on small biopsy specimens and the definite diagnosis may only be established after the detailed examination of the excised tumour. The highly malignant behavior of the laryngeal type was noted. To our knowledge this is only the second report on giant cell carcinoma of the larynx.
A rare case of angiolymphoid hyperplasia with eosinophilia, or Kimura's disease, of the external ear, occurring in a 21-year-old woman, is reported. The lesion has recurred twice after surgical excision and corticosteroid therapy was then elected. The clinical and histological features of this disease are described.
A case of chondrometaplasia of the larynx is reported. The clinicopathological appearances are discussed with a review of the literature. The importance of distinguishing this lesion from cartilaginous tumors is emphasized.
A large pedunculated vocal cord polyp containing numerous atypical stromal cells is described. The lesion was originally misinterpreted as malignant neoplasm. Follow-up data showed that the polyp was benign and adequately treated by local excision.
The clinical and pathologic findings in eleven cases of parapharyngeal space tumors are described. The anatomy of this area and diagnostic procedures are discussed. Investigations should include a few basic examinations such as sialogram-computed tomographic (CT) scan, carotid angiogram, and echography. Several surgical approaches are considered in relation to the site and the size of the neoplasm. Prognosis depends on the histologic type of the tumor.
2 cases of laryngeal metastases from malignant melanoma of the skin have been observed at the ENT Department of Padua University during the last 17 years (from January 1966 through December 1982). A critical review of the pertinent literature is made and the metastatic spread to the larynx is also discussed. The importance of routine indirect laryngoscopy in neoplastic patients 'at risk' is underlined.
An unreported case of metachronous coexistence of laryngeal pseudolymphoma and squamous cell carcinoma is described. The long follow-up of the patient (above 11 years), without any evidence of lymphoreticular disease elsewhere, was in favor of a diagnosis of lymphoid hyperplasia of the larynx. The occurrence in the same organ of a squamous cell carcinoma has allowed the thorough investigation of the reactive lesion. The additional cases of laryngeal pseudolymphoma reported in the English literature are reviewed.
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Anaplastic small cell (oat cell) carcinoma is a neoplasm commonly arising in the lungs. However, it may also occur, though rarely, in the larynx. A series of 43 cases is presented (ten cases from the Armed Forces Institute of Pathology, eight from the Department of Otolaryngology of the Padua University, and 25 from the literature). The tumor often presents in the sixth and seventh decades of life and appears to be highly aggressive, and metastases develop early. The most common presenting symptom is hoarseness. As in pulmonary small cell carcinoma, prognosis is poor and does not seem to depend upon therapeutic modalities, tumor location or the extent of initial local disease. The tumor seems to derive from the Kulchitsky cell present not only in the bronchial mucosa but also in the laryngeal lining. Like pulmonary anaplastic small cell carcinoma, small cell carcinoma of the larynx should be treated with systemic chemotherapy and radiotherapy. The association of small cell carcinoma with squamous carcinoma of the larynx is also reported and problems connected with the histogenesis of this mixed tumor are discussed.
After describing 4 new cases of malignant fibrous histiocytoma of the larynx (3 cases had been recently published), the authors review the literature, from which it appears that 16 such lesions of the larynx have been reported (including their 7 cases). Malignant fibrous histiocytoma usually occurs in the soft tissues, tendons and joints of the upper and lower extremities, and is uncommon in the head and neck--though not exceptional. The lesion is a mesenchymal tumor probably of histiocytic origin and may be divided into 6 subtypes, i.e., pleomorphic, fibrous, giant cell, angiomatoid, myxoid and inflammatory, to be distinguished on the basis of the predominant feature. The tumor has an aggressive biologic behavior as it tends to recur and to metastasize to distant organs. The treatment of choice is surgery and adjuvant combination chemotherapy which at times may improve the survival rate.
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Two cases of adenoid cystic carcinoma of the larynx are reported with a review of the world literature. This tumour, though capable of metastasizing via the blood stream to various organs (brain, lung, bone, etc.), seldom spreads to the cervical lymph nodes, usually by direct infiltration. Because of the biological behaviour of the neoplasm, radical neck dissection is not indicated.
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