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Biomedical subjects

A Fenster

Publications and source records attributed to A Fenster.

118 records · Page 7Linked to original sources
PubMedDate not supplied

A digital-radiographic technique for in vitro tissue thickness measurement using iodine displacement.

A novel digital radiographic method has been developed for measuring the thickness of a tissue sample by iodine displacement. This simple, accurate method is useful both in medical research and in the comparison of pathological and clinical findings. Radiographic measurements of tissue samples in air suffer from the limitation that the quantity measured depends on the product of both thickness and radiographic attenuation coefficient. This technique allows one to obtain thickness measurements from a digital radiograph of a tissue sample suspended in a bath of radio-opaque contrast agent. The attenuation of the iodinated contrast agent is much higher than that of tissue or calcium. Thus the resulting image is determined largely by the contour of the surrounding bath, and is only slightly influenced by the composition of the tissue. This technique improves both the accuracy and precision of radiographic thickness determination. In this paper the iodine displacement technique is described and the accuracy and precision of thickness measurements in appropriate phantoms are quantified. This technique has been used with both image intensifier and screen-film based imaging systems to obtain thickness maps of calcified human aorta, with precision better than 4% and spatial resolution of 2.5 mm-1.

Aged↗
PubMedDate not supplied

A review of electronic portal imaging devices (EPIDs).

On-line electronic portal imaging devices are beginning to come into clinical service in support of radiotherapy. A variety of technologies are being explored to provide real-time or near real-time images of patient anatomy within x-ray fields during treatment on linear accelerators. The availability of these devices makes it feasible to verify treatment portals with much greater frequency and clarity than with film. This article reviews the physics of high-energy imaging and describes the operation principles of the electronic portal imaging devices that are under development or are beginning to be used clinically.

Humans↗
PubMedDate not supplied

A modified x-ray image intensifier with continuously variable field of view: resolution considerations.

A conventional x-ray image intensifier (XRII) has been modified to enable the field of view (FOV) to be varied continuously, by adjusting the potentials at the focusing electrodes. The benefit, to system resolution, from decreasing the FOV has been characterized by measuring the modulation transfer function (MTF) of the XRII coupled to a high-resolution photo-diode array (PDA), at a number of different FOVs achieved either by electronic or optical zooming. Electronic zooming of the XRII from FOV = 24 cm to FOV = 10 cm led to an increase in f0.1 (the frequency at which MTF = 0.1) from 1.41 to 3.05 mm-1, while optical zooming increased f0.1 from 1.41 mm-1 only to 1.88 mm-1. It is proposed that the advantage, with respect to resolution gain, of electronic zooming over optical zooming was realized only when the XRII limits system resolution. The MTF of the XRII coupled to a video camera, with lower resolving power than the PDA, was measured at different FOVs to show that using electronic zooming is only marginally beneficial when the optical detector and the XRII contribute equally to the resolution degradation. However, when a higher-resolution optical detector is used, electronic zooming always yields a greater gain in resolution.

Fluoroscopy↗
PubMedDate not supplied

A high-resolution XRII-based quantitative volume CT scanner.

A laboratory volume CT scanner has been developed, with high spatial resolution in all three dimensions, which can be used for quantitative analysis of excised tissue samples in vitro. The system incorporates an x-ray image intensifier, optically coupled to a time-delay integration (TDI) CCD to obtain low-noise and low-scatter projections of the sample volume. A water bath surrounds the sample to equalize the exposure to the image intensifier, thereby reducing the dynamic range of the input signal. The scanner operates in two modes, producing either a single, transverse image through the sample or a three-dimensional image of the sample volume. Spatial resolution is adjustable over the range of 1.2 to 2.8 mm-1. System response is linear over the range -1000 to 3500 Houndsfield units (HU), with an average precision of +/- 80 HU. The precision of geometric measurements in the transverse plane allows circumference measurements to within +/- 0.1 mm. Finally, applications of this technique of nondestructive analysis in biomedical research are discussed.

Aged↗
PubMedDate not supplied

X-ray sources of medical linear accelerators: focal and extra-focal radiation.

A computerized tomography (CT) reconstruction technique has been used to make quantitative measurements of the size and shape of the focal spot in medical linear accelerators. Using this technique, we have measured the focal spots in a total of nine accelerators, including (i) two Varian Clinac 2100c's, (ii) two Atomic Energy of Canada Ltd. (AECL) Therac-25's, (iii) two AECL Therac 6's, (iv) a Siemens KD-2, (v) a Varian Clinac 600c (4 MV), and (vi) an AECL Therac-20. Some of these focal spots were monitored for changes over a 2-yr period. It has been found that (i) the size and shape of the source spot varies greatly between accelerators of different design ranging from 0.5 to 3.4 mm in full width at half maximum (FWHM); and (ii) for accelerators of the same design, the focal spots are very similar. In addition to the measurements of the focal spot, a new technique for measuring the magnitude and distribution of extra-focal radiation originating from the linear accelerator head (flattening filter, primary collimator) has also been developed. The extra-focal radiation produced by a Varian Clinac 2100c accelerator was measured using this technique and it was found that the extra-focal radiation accounts for as much as 8% of the total photon fluence reaching the isocenter. The majority (75%) of this extra-focal radiation originates from within a circle 6 cm in diameter at the target plane. The source MTFs for each of the measured focal spots have been calculated in order to assess their influence on the spatial resolution of verification images. The limiting spatial resolution (i.e., 10% modulation) for all the source MTFs is 1.8 mm-1 or greater when used for transmission radiography at a magnification of 1.2. The extra-focal radiation, which produces a low-frequency drop in the source MTFs of up to 8%, changes with field size. As a result, the source MTFs of linear accelerators depend not only on the design of individual accelerators and image magnification, but also on the field size used when forming an image.

Biophysical Phenomena↗
PubMedDate not supplied

Experimental and theoretical x-ray imaging performance comparison of iodine and lanthanide contrast agents.

Contrast agents based on the lanthanide elements gadolinium and holmium have recently been developed for magnetic resonance imaging (MRI). Because of the increased atomic number of these elements relative to iodine, these new compounds, used as x-ray contrast agents, may yield higher radiographic contrast, and hence improved x-ray image quality, relative to conventional iodinated compounds, for clinically useful x-ray spectra. This possibility has been investigated, in independent experimental and theoretical studies, for two x-ray imaging systems: a digital radiographic system, using an x-ray image intensifier (XRII) and charge-coupled device (CCD) detector; and a conventional screen/film system, using a Lanex Regular screen. Iodine, gadolinium, and holmium contrast agents were investigated over a wide range of concentration-thickness products (0.1-0.6 M cm) and diagnostic x-ray spectra (60-120 kVp). A simple theoretical model of x-ray detector response predicts the experimental radiographic contrast measurements with a mean absolute error of 8.0% for the XRII/CCD system and 5.9% for the screen/film system, and shows that the radiographic contrast for these two systems is representative of all XRII and screen/film systems. An index of image quality is defined, and its dependence on radiographic contrast, x-ray fluence per unit dose, and detective quantum efficiency (DQE) is shown. Theoretical values of the index, predicted by our model, are then used to compare the performance of the three contrast agents for the two systems investigated. In general, iodine performance decreases steadily with increasing kVp, gadolinium performance has a broad maximum near 85 kVp, and gadolinium outperforms holmium. Gadolinium outperforms iodine for spectra above (and vice versa below) about 72 kVp, depending slightly on spectrum filtration, object thickness, and detector type. Thus, raising the kVp to shorten exposure times or reduce x-ray tube heat loading results in a loss of image quality with iodine, but not with gadolinium. Similarly, beam-hardening artifacts in performing video densitometry with iodine would be reduced with gadolinium. Gadolinium-based contrast agents are thus shown to offer several practical advantages over conventional iodinated contrast agents.

Biophysical Phenomena↗
PubMedDate not supplied

A geometrically accurate vascular phantom for comparative studies of x-ray, ultrasound, and magnetic resonance vascular imaging: construction and geometrical verification.

A technique for producing accurate models of vascular segments for use in experiments that assess vessel geometry and flow has been developed and evaluated. The models are compatible with x-ray, ultrasound, and magnetic resonance (MR) imaging systems. In this paper, a model of the human carotid artery bifurcation, is evaluated that has been built using this technique. The phantom consists of a thin-walled polyester-resin replica of the bifurcation through which a blood-mimicking fluid may be circulated. The phantom is surrounded by an agar tissue-mimicking material and a series of fiducial markers. The blood- and tissue-mimicking materials have x-ray, ultrasound, and MR properties similar to blood and tissue; fiducial markers provide a means of aligning images acquired by different modalities. The root-mean-square difference between the inner wall geometry of the constructed model and the desired dimensions was 0.33 mm. Static images were successfully acquired using x-ray, ultrasound, and MR imaging systems, and are free of significant artifacts. Flow images acquired with ultrasound and MR agree qualitatively with each other, and with previously published flow patterns. Volume-flow measurements obtained with ultrasound and MR were within 4.4% of the actual values.

Carotid Arteries↗
PubMedDate not supplied

Clinical utility of three-dimensional US.

Three-dimensional (3D) ultrasonography (US) is rapidly gaining popularity as it moves out of the research environment and into the clinical setting. This modality offers several distinct advantages over conventional US, including 3D image reconstruction with a single pass of the US beam, virtually unlimited viewing perspectives; accurate assessment of long-term effects of treatment; and more accurate, repeatable evaluation of anatomic structures and disease entities. In obstetric imaging, 3D US provides a novel perspective on the fetal anatomy, makes anomalies easier to recognize, facilitates maternal-fetal bonding, and helps families better understand fetal abnormalities. Three-dimensional pelvic US allows volume data sets to be acquired with both transvaginal and transabdominal probes. Viewing multiple 3D power Doppler US images in a fast cine loop has proved useful in angiographic applications. Three-dimensional prostate US can help make accurate volume assessments for dosimetry planning or for estimating prostate-specific antigen levels. In breast imaging, 3D US has the capacity to demonstrate lesion margins and topography, thereby helping differentiate benign from malignant masses. Three-dimensional US can also help determine the need for biopsy and help facilitate needle localization and guidance during biopsy. With recent advances in computer technology and display techniques, 3D US will likely play an increasingly important role in medicine.

Biopsy↗
PubMedDate not supplied

A scanning x-ray imaging system for quantitative arteriography and blood flow measurements.

The authors have developed a new x-ray imaging system for quantitative arterial imaging and blood flow measurements. The system is based on the scanned projection technique and employs an x-ray beam collimated into a fan of radiation and an x-ray image intensifier optically coupled to a 1024-element linear photo-diode detector array. The system has two modes of operation: quantitative projection imaging and blood flow measurements. In the first mode of operation, low-noise, quantitative images are obtained by irradiating small regions of interest to minimize the detection of scattered radiation and intensifier tube veiling glare. System performance is optimized by making use of the large dynamic range (8,000:1) and response linearity of the solid-state photo-detector. In the second mode of operation, flow information is obtained by detecting the passage of a small bolus of iodine contrast agent.

Angiography↗