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Biomedical subjects

A Fazekas

Publications and source records attributed to A Fazekas.

At least 73 records · Page 4Linked to original sources
PubMed1990

Experimentally-induced neurogenic inflammation in the rat oral mucosa.

Blood flow and vascular permeability in the gingiva and alveolar mucosa of the lower jaw were studied after the antidromic (electric) or orthodromic (topical administration of capsaicin onto the oral mucosa) stimulation of the inferior alveolar nerve (IAN) in rats with or without capsaicin pretreatment. Blood flow was determined using 86Rb isotope dilution technique, while vascular permeability was assessed by the Evans blue extravasation. Both antidromic or orthodromic stimulation of the IAN increased blood flow and Evans blue extravasation. Capsaicin pretreatment abolished the increase in gingivo-mucosal blood flow and vascular permeability induced by nerve stimulation. The results of the present study appear to confirm the possibility of the development of neurogenic inflammation in the oral cavity. The mechanism observed may play a role in the development of certain inflammatory reactions in the oral mucosa frequently encountered in human clinical practice.

Animals↗
PubMed1990

[Gardner syndrome].

A case of Gardner syndrome associated with alterations of the skin and bones and precancerous gastrointestinal polyposis is presented. Particular interest attached to the extension of polyposis to the entire digestive tract, the early appearance of abdominal signs attributable to the polyposis, and - as new symptoms - polycystic lung and widespread superficial naevus lipomatosus.

Adolescent↗
PubMed1987

An epidemiologic study of mandibular dysfunction dependence on different variables.

Age and sex characteristics of different signs and symptoms of mandibular dysfunction were studied in 600 randomly selected urban persons. With regard to mandibular mobility marked differences were observed between the sexes, and a steady decrease parallel with ageing. Against this, the percentages of the objective dysfunction signs of impaired mobility and TMJ-sounds, as well as those of the pooled percentages of all the objective signs (Di-I + II + III), increased parallel with ageing. The percentages of headache occurrence peaked in different age groups for men and women. Statistically significant correlations were found between headache, parafunctions, stress, age, the existence of a preferred chewing side, as well as several dental-occlusal factors, and the prevalence of mandibular dysfunction; between Ai and Di according to Helkimo, and between excessive tooth wear and parafunctions.

Adolescent↗
PubMed1986

Prevalence of mandibular dysfunction in an urban population in Hungary.

600 randomly selected subjects from an urban community in Hungary were examined anamnestically and clinically concerning signs and symptoms of mandibular dysfunction. The anamnestic (Ai) and clinical dysfunction (Di) indices according to Helkimo were used. The percentage distribution of the sample was the following: AiO = 79.3%, AiI = 15.3%, AiII = 5.3%; DiO = 20.1%, DiI = 72.3%, DiII = 7%, DiIII = 0.5%. Headache was reported in 23%, bruxism in 10%, joint sounds in 9%, pain in the face, neck, or around the ears in 6%. Clinical signs found at the examination were joint sounds in 46% (crepitation 29%, clicking 22%), muscle tenderness on palpation in 17%, joint tenderness in 3%, pain on movement in 2.5%, restricted mouth opening in 4%, deviation of the mandible in 20%.

Adolescent↗
PubMed1986

[Not Available].

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History, Modern 1601-↗
PubMed1985

Effect of indomethacin on the bradykinin-induced vasodilation in the submandibular gland.

Effects of the local infusion of bradykinin or isoproterenol were studied on the systemic blood pressure, blood flow, and vascular resistance of the submandibular gland before and after indomethacin treatment in cats. Both bradykinin and isoproterenol were shown to potently increase the glandular perfusion rate. The systemic arterial blood pressure fell by about 20% in response to indomethacin. The enhancement of blood flow by bradykinin or isoproterenol was not, however, affected by indomethacin treatment. The present results appear to suggest that the endogenous prostaglandins are not essentially involved in the development of responses produced by bradykinin or isoproterenol in the cat submandibular gland.

Animals↗
PubMed1985

Neuropeptide Y (NPY) and sympathetic control of blood flow in oral mucosa and dental pulp in the cat.

Neuropeptide Y (NPY) immunoreactivity (-IR) was found to be present in perivascular nerves in the cat dental pulp and oral mucosa. Many ganglion cells in the superior cervical ganglion also contained NPY-IR. Ligation of the inferior alveolar or lingual nerves produced an accumulation of NPY-IR in axons proximal to the site of ligation, suggesting an anterograde axonal transport of the peptide. After unilateral sympathectomy the NPY-IR disappeared in the dental pulp and oral mucosa on the ipsilateral side. Reversed phase high performance liquid chromatography showed that the main peak of NPY-like immunoreactivity found in the superior cervical ganglion co-chromatographed with synthetic porcine NPY. Changes in blood flow in dental pulp or oral mucosa were measured indirectly by recording local clearance of 125I during electrical stimulation of the sympathetic nerve or during close intra-arterial infusion of noradrenaline or NPY. All three procedures resulted in a pronounced decrease in local blood flow of a similar magnitude in both tissues. After alpha-adrenoceptor blockade with phentolamine, the vasoconstrictor effect of noradrenaline was abolished. However, the effect of sympathetic stimulation after phentolamine was only partially reduced (23-54%) and the response to NPY was almost unaffected by the alpha-receptor blockade. The remaining effect of sympathetic stimulation after phentolamine was abolished by guanethidine. However, the response to NPY was not changed by the latter drug. In conclusion, the vasoconstrictor response in the dental pulp and oral mucosa caused by activation of sympathetic nerves is more resistant to phentolamine than the response induced by infusion of exogenous noradrenaline. Since NPY is probably co-localized with noradrenaline in the sympathetic perivascular nerves and NPY reduces local blood flow, it is proposed that this peptide is involved in sympathetic vascular control in oral tissues.

Adrenergic alpha-Agonists↗