Search PubMed⌕ Search

Biomedical subjects

A Fantoni

Publications and source records attributed to A Fantoni.

At least 91 records · Page 5Linked to original sources
PubMed1969

Differentiation of mammalian somatic cells: DNA and hemoglobin synthesis in fetal mouse yolk sac erythroid cells.

The relationship between the synthesis and replication of DNA and the capacity to synthesize specialized protein on a stable messenger RNA has been examined in yolk sac erythroid cells differentiating in vivo in fetal mice. Evidence is presented that by day 11 of gestation, at least 98 per cent of yolk sac erythroid cells are synthesizing hemoglobin. These cells are shown to incorporate (3)H-thymidine and to replicate, with more than twofold increase in cell number between days 10 and 11. Division of these cells continues through day 13. Hemoglobin formation in these cells is resistant to actinomycin D from day 10. During this period, ribosomal content per cell decreases by more than a factor of 2. These data indicate that in yolk sac erythroid cells, hemoglobin formation proceeds independent of continued RNA formation in cells capable of DNA synthesis and replication.

Animals↗
PubMed1967

Globin composition and synthesis of hemoglobins in developing fetal mice erythroid cells.

Fetal mouse erythropoiesis proceeds initially in yolk-sac blood islands (8 to 12 days) and, subsequently, in liver (12 to at least 16 days). Yolksac cells synthesize three hemoglobins, Hb E(I), Hb E(II) and Hb E(III). Hb E(I) has x- and y-globin chains; Hb E(II) has alpha and y; HB E(III), alpha and z. No detectable beta-globin is formed in these cells. Liver erythroid cells form only adult hemoglobin, composed of alpha- and beta-chains.

Animals↗