Search PubMed⌕ Search

Biomedical subjects

A Fabiyi

Publications and source records attributed to A Fabiyi.

At least 55 records · Page 3Linked to original sources
PubMed1976

Herpes type-2 virus antigens in human cervical carcinoma.

Exfoliated cells from the cervices of 22 patients with histologically diagnosed squamous cell carcinoma of the cervix and from those of 24 control women were examined for herpes subtype 2 (HT-2) antigens by indirect immunofluorescence studies. This method demonstrated that cells from all the patients with carcinoma contained antigens related to HT-2 virus. In contrast, squamous cells from the cervices of 24 control women with no cervical disease and of 2 women with chronic cervicitis did not contain such HT-2 antigens. Although an etiologic role of HT-2 virus infection cannot yet be established, it is probable that such infection precedes neoplastic changes.

Adult↗
PubMed1976

Neutralizing antibodies to Orungo virus in man and animals in Nigeria.

Sera from humans, birds, domestic and wild animals, from 17 localities in four ecological zones of Nigeria were tested for neutralizing antibody to Orungo virus. A total of 1197 human sera were tested, of which 277 (23.1%) were positive for Rungo antibody. The highest prevalence (34.2%) was found in the northern Guinea Savannah zone. The prevalence in the other zones were 29.9% in the Southern Guinea Savannah, 24.3% in the Derived Savannah and 17.0% in the rainforest. Significant differences in antibody prevalence were found between, the wet forested area and the drier Savannah regions, with an increasing trend from the wetter to the drier zones. Over 50% of sheep, with about 24% of monkeys and 14% of cows tested were positive for Orungo virus N antibody. It is suggested that man and animals are involved in the transmission cycle of Orungo virus in Nigeria, possibly with Aedes spp. mosquitoes acting as an important vector.

Animals↗
PubMed1975

Antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in Ibadan, Nigeria.

Carcinoma of the cervix is by far the commonest gynecologic malignancy seen in Ibadan, Nigeria. In a study aimed at investigating the role of herpesvirus type 2 (HT-2) in its pathogenesis, antibodies to HT-2 were detected by immunofluorescence above a titer of 640 in 31 (70.5 percent) of 44 women with invasive carcinoma of the cervix as compared with five (11.1 percent) of 45 healthy women of the same age group. Analysis according to histologic types of growths showed that 31 (83.8 percent) of 37 cases of squamous-cell carcinoma had antibodies above a titer of 640, whereas none of the other types (one adenocarcinoma and six undifferentiated carcinoma of the cervix) had antibodies above this titer. It was concluded that the results of the present study support the hypothesis of an association between HT-2 and carcinoma of the cervix, most especially the squamous-cell type.

Antibodies, Neoplasm↗
PubMed1975

Use of the complement fixation (CF) test in Lassa fever surveillance. Evidence for persistent CF antibodies.

A survey to detect individuals with antibodies to Lassa virus was undertaken among hospital personnel in the eastern and southern provinces of Sierra Leone late in 1974. Sera were evaluated by the complement fixation test. The data obtained showed that some contacts of Lassa fever patients in the 1972 epidemic had developed antibodies to the virus; individuals who had never reported being sick also showed evidence of infection, with significant CF antibody titres in their sera. Surviving Lassa fever patients from the 1972 epidemic still had easily measurable levels of persisting CF antibodies. The significance of these data is discussed; in addition it is recommended that the CF test should continue to be the method of choice in mass surveys for this virus disease until other tests can be developed.

Adolescent↗
PubMed1975

Recent isolations of Lassa virus from Nigerian rodents.

Rodents were trapped in the Benue-Plateau and North-Eastern States of Nigeria where Lassa fever had been reported in previous years. Eight Lassa virus strains were isolated from tissues and blood of rodents identified in the field as being of 3 different species: Mastomys natalensis, Rattus rattus, and Mus minutoides. All the infected rodents were collected in village habitats. These isolations indicate the presence of Lassa virus in wild rodents in Nigeria during periods when no human infections were evident.Prior studies in Sierra Leone have indicated that a single rodent species, M. natalensis, may be the important reservoir host of Lassa virus. Since the present study indicates that other rodent species may be involved as well, the ecology of Lassa virus may be more complicated than was heretofore supposed. In view of the importance of determining the geographic and species range of rodent hosts of Lassa virus, and because of the problems inherent in rodent identification under austere field conditions, it is urgent that further studies be conducted in the same areas of Nigeria to confirm these findings.

Animals↗
PubMed1975

Arbovirus studies in two towns in western state of Nigeria.

Three hundred and fifty-one persons were tested for HI antibody to arbovirus Groups A, B and Ingwavuma viruses in Ilesha and Oshogbo, two towns in western Nigeria. Chikungunya accouted for most Group A infections (39%). Antibodies to Group B virus were distributed as follows: Dengue 22%, Yellow Fever 25%, West Nile 28% and Wesselsbron 30%. Few sera 5% were positive to Ingwavuma. No virus was isolated from 188 blood specimens processed for virus isolation.

Adolescent↗
PubMed1975

Experimental Rift Valley fever in West African Dwarf sheep.

West African Dwarf sheep were challenged with a low mouse brain-passaged Rift Valley fever virus (Ib-AR 55172) isolated from Nigeria. Viraemia, mild febrile reaction and neutralising antibodies were demonstrated in inoculated animals.

Africa, Western↗
PubMed1975

The 1974 epidemic of Chikungunya fever in children in Ibadan.

During an epidemic of Chikunguya fever in Ibadan 16 strains of Chikungunya virus were recovered from children reporting sick with fever at the University College Hospital and Oluyoro Catholic Hospital Outpatient Clinic. Twelve strains were obtained from children within the 1-4 year age group, two from 5-10 year group and one each from less than one-year age group, and 10-15 year age group. A retrospective survey for neutralising antibodies to Chikungunya shows a significantly higher proportion of children were positive for Chikungunya N antibodies just after the 1969 epidemic than in 1974 just before the epidemic, with resultant pooling of Chikungunya seronegative children who are susceptible to infection.

Adolescent↗
PubMed1975

A survey for Ilesha Bunyamwera group virus antibodies in sera from domestic animals and humans in three ecological zones of Nigeria.

343 persons, 58 children and 285 adults, from three ecological zones: rainforest, savannah, and plateau were tested for the presence of Ilesha virus N antibodies in their sera. Neutralization tests were conducted in suckling mice using the constant virus--constant serum technique. 155 subjects (45%) had Ilesha immunity: 22 children (38%) and 133 adults (44%). The highest percentage of positive sera was found in the savannah (54%), followed by the plateau and rainforest. A further analysis of the results shows that the virus is more active in rural communities than in urban centres. A total of 68 sera from domestic animals (cows, sheep, goats, and pigs) were tested. Antibodies were found only in cows and goats. The absence of antibodies in sheep and pigs may be due to the small number of sera tested.

Adult↗
PubMed1975

Experimantal Congo virus (Ib -AN 7620) infection in primates.

Three primates inoculated with Congo virus (CV) developed viremia. The animals showed neither any rise in rectal temperature, nor signs of overt disease; however, in one of them pruritus and rash were observed. Skin biopsy revealed vasculitis and hemorrhage. By complement fixation, neutralization and gel diffusion tests CV antibodies were demonstrated in the convalescent sera of the three animals.

Animals↗