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Biomedical subjects

A Eskenasy

Publications and source records attributed to A Eskenasy.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

The cylindrocubic carcinomas of the lung (the so-called adenocarcinomas). A histopathological analysis of 725 cases.

A histopathological and histochemical analysis of 725 cases of cylindrocubic carcinomas of the lung was performed: 570 cases were surgically removed specimens, 98 bronchial and 46 extrathoracal biopsies from unoperable cases, and 11 autopsies. Histopathology of operated cases revealed the co-existence and intrication in different proportions of immature cell areas with dense proliferations containing many giant, monstrous cells, with others trabecular, acinar, cribriform-areolar, pseudoglandular, tubular, papillar and glandular-secretory areas; most of these cellular dispositions were related to the lung stromal development (scars, fibrotic areas); 117 out of the 570 cases were independent, multicentric, true bronchiolo-alveolar carcinomas, and 48 cases were true glandular-secretory carcinomas of the large bronchi. 143 out of the 570 cases developed upon scars and fibrotic areas; in 42 out of these 143 the pericicatricial invasion was bronchiolo-alveolar-like. The study of small tumors and of bronchial biopsies revealed mostly the peripheral origin of these cylindrocubic carcinomas from the bronchial covering epithelia of small, nonglandular bronchi. The term of adenocarcinoma does not correspond to the predominant histological picture of these lung tumors, and the so-called subtypes of the WHO typing are currently represented in the same tumors concomitantly and in various proportions. The histodiagnosis of these lung carcinomas is facilitated by the presence of well differentiated, glandular-secretory areas and has to be based upon the predominant aspects of the tumoral growth.

Adenocarcinoma↗
PubMedDate not supplied

Alveolar macrophagic reactions. V. Ultrastructure of alveolar wall changes (mural alveolitis).

Ultrastructural observations of alveolar walls after intratracheal administration of aluminium silicate and parenteral injection of heparin are reported. The alveolar walls appeared cellularly thickened and shortened, the air spaces reduced, the basement membranes undulated. The number of intermembranary interstitial cells of histiocytary-macrophagic type is increased, the granulous alveolocytes are concentrated mostly at the intersection of alveolar walls, the fibroblast-fibrocytes as well. The flat alveolocytes with their large cytoplasmic expansions covered the reduced surface of air spaces. Macrophages contained amorphous masses of aluminium silicate within giant phagosomes.

Animals↗
PubMedDate not supplied

Electronmicroscopic observations on epidermoid (squamous cell) carcinomas of the lung.

Five epidermoid (squamous cell) carcinomas of the lung histopathologically diagnosed were ultrastructurally analysed; special attention was given to the poorly differentiated-immature areas of proliferation. Wide intercellular spaces between irregular cytoplasms with protrusions and microvilli, a high incidence of indentations of nuclear membranes, a large amount of nuclear bodies, shape, size and structure anomalies of mitochondria, a great number of desmosomes and of tonofilaments and tonofibril bundles and their relations with desmosomes and with the finger-like cytoplasmic expansions were noticed. A few secretory granules were also present in these poorly differentiated-immature areas of epidermoid carcinomas of the lung.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Lung pathogenesis. V. The stereotype development of bronchial and lobular pathological reactions (a systemic approach).

Taking into account the present data upon the general stereotyping of different pathological processes of various nature challenged by the extremely numerous environmental actions, a structural analysis of the peculiarities presented by such reactions at the lung level, mainly on bronchial and lobular structures, was attempted. It was shown that the first damaged structures and their behaviour impose the peculiarities of the subsequently developed reactions which manifest a certain stereotyping, different when bronchi or lobules are the first lesioned. Relationships between bronchial and lobular lesions were also analysed and pointed out their role in the development of the whole complex process of the lung. This special aspect of lung complex pathogenesis was also emphasized.

Bronchi↗
PubMedDate not supplied

The epidermoid (squamous cell) carcinomas of the lung. A histopathological analysis of 2,150 diagnosed cases.

A histopathological analysis of 2,150 cases of lung epidermoid (squamous cell) carcinomas, diagnosed between March 1949 and December 1983, was performed. The ratio men/women was 14.9:1. The study included 851 lung surgical specimens (199 pulmonectomies, 456 lobectomies and 196 segmentectomies, atypical resections and lung biopsies). 1,103 bronchial biopsies of inoperable cases, 91 peripheral lymph node biopsies, 19 pleuroparietal biopsies, and 86 autopsies. Immature, unkeratinized forms were found in 471 cases, a low tendency to keratinization in 830 cases, and mature, well keratinized forms in 849 cases. Necrosis of neoplastic tissue occurred in 332 cases (15.5 per cent). The most frequent metastases were found in hilar and mediastinal lymph nodes: 71 surgical specimens and autopsies. In the ensemble of histodiagnosed cases of lung carcinomas (between 1949 and 1983), the epidermoid carcinomas of the lung, which presented an incidence of about 55 per cent 15 years ago, have decreased to 36 per cent in the last five years. Differentiating criteria between immature forms of epidermoid, cylindrocubic and macrocellular carcinomas of the lung were established. The importance of epidermoid metaplasia of bronchial epithelium and of intraepithelial proliferations in the histogenesis of epidermoid carcinomas of the lung is discussed in the light of experimental data.

Biopsy↗
PubMedDate not supplied

[Pulmonary biopsy].

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Biopsy↗
PubMedDate not supplied

Arguments for a histogenetic classification of lung carcinomas.

Taking into consideration the common origin of lung carcinomas from the basal-intermediate cells of covering epithelia of bronchi and bronchioles (which have preserved their ability to divide and differentiate under different stimuli), and the development of tumors in at least two phases, the main histogenetic characteristics of lung carcinomas are discussed. There are pointed out the various and multiple promoting factors acting at the level of proliferating cell foci resulted from the initiating action of chemical carcinogens and the varied deepness of the cellular changes induced. Under these conditions, the malignantly transformed cells may remain poorly differentiated, like during the histogenesis of macrocellular carcinomas (which might be influenced in the course of proliferation, within some limits, by active factors), they may preserve the stereotype of cylindrocubic development, like during the formation of cylindrocubic carcinomas (bronchiolo-alveolar cell carcinomas included), or may suffer metaplastic changes and form subsequently epidermoid carcinomas; the inclusion of Kultschitzky-APUD cells within proliferating foci may lead to bronchial carcinoids or to microcellular carcinomas. The particular forms of lung carcinomas (giant celled, adenocystic, mucoepidermoid) histogenetically reflect the mixed or concomitant stereotypical evolutions of basal cells while preserving some secretory possibilities.

Adenocarcinoma↗
PubMedDate not supplied

Mechanisms of lung tissue restructuration. A structural analysis of experimental and human materials.

Lung tissue restructuration is one of the most important components of chronic pneumopathies. Comparison of experimental and human data regarding the dynamic evolution of variously induced chronic lung processes pointed out as main mechanisms the bronchial and bronchiolar obstructions, the viral and fungal pneumonitic processes, the parenchymatous suppurative processes, the granulomatous organization of cellular reactions, the interlobular cell accumulations, the hypersensitivity reactions, and the lesions of small vessels. Mostly acting in association, these dynamic conditions determine the fibroplastic transformation of lesions, the exclusion of unventilated areas, the destruction of respiratory surfaces, the clear predominance of connective tissue structures, sometimes with ossifications; some microcavities persist within restructuring areas, sometimes delimited by alveolar or bronchiolar epithelia. The honeycomb lung is one of the evolutive possibilities of this restructuration of damaged tissues during chronic lung diseases.

Animals↗
PubMedDate not supplied

Bronchiolar pathology. I. Histopathology of small bronchi and bronchioli in some chronic lung diseases.

Different types of lesions in small bronchi and bronchioli in a hundred lungs or lobes resected for chronic lung diseases (suppurations, chronic pneumonitides, tumours) were evidenced and interpreted in the light of experimental results and in relation to the lung processes in their entirety. Inflammatory, exudative and proliferative lesions, primary and secondary changes, as well as evolutive modifications were discerned. Their structural analysis demonstrated the influence of persisting aerogenic agents of the infections, antigenic or common types, some correlations with the surrounding parenchyma primarily or secondarily involved, and possible mechanisms determining the lesions of small bronchi and bronchioli. Inflammatory changes of the lung tissue following those of bronchi are evident within chronic suppurations with or without bronchiolectasias, with a varied restructuration of the lung tissue. The role of the immunopathogenic component was emphasized not only in chronic pneumonitides, but also in other cases. Proliferative changes of respiratory bronchioli were only rarely found in distal zones of lungs resected for tumours. Relationships between bronchiolar lesions and parenchymatous changes of the centrolobular emphysema type were never evidenced in the analysed cases.

Bronchi↗
PubMedDate not supplied

Eosinophilic granulomas of the lung. Histopathology of three cases.

Three cases of eosinophilic granuloma of the lung were histopathologically analyzed on surgical materials (two resections and lung biopsy). The analysis insisted upon the cell components of pulmonary lesions, histiocytic and eosinocytic accumulations involving lobular air spaces, alveolar walls and interlobular areas, and forming bullae by histiocytic enzymic activity and lipid dysmetabolism; the fibrotic evolution of the lesions varied from case to case. The lesional histogenesis is discussed in the light of recent electronmicroscropic, histochemical and immunopathological data, stress being laid upon the local influence on the development of the process.

Adult↗
PubMedDate not supplied

Ultrastructure of a bronchial mucoepidermoid tumour of a seven-year-old boy.

A bronchial mucoepidermoid tumour of a 7-year-old boy was histopathologically and electronmicroscopically studied. The light microscopy revealed an epidermoid structure in whose cells an intracellular and extracellular accumulation of acid mucopolysaccharides occurred. The origin of this transformation seems to be located within the cells of a glandular duct. Electron microscopy pointed out the main characteristics of epidermoid cells (tonofibrils, cellular junctions of desmosomal type) and the secretory transformation by the large development of polyribosomes, of the rough endoplasmic reticulum and of dilated cisternae filled with the secretory product. The prolonged evolution with repeated obstructive pneumonitides, the proliferation after partial endoscopic resection, the absence of mitoses and invasion, as well as the late evolution of the case, suggested the semi-malignancy of this tumour and the impossibility of its consideration as a mucoepidermoid carcinoma. The hypothesis of a unique class of tumours with different secretory possibility including carcinoids, cylindromas (adenocystic tumours) and mucoepidermoid tumours is sustainable.

Bronchial Neoplasms↗