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Biomedical subjects

A Encke

Publications and source records attributed to A Encke.

At least 181 records · Page 10Linked to original sources
PubMed1982

[Zollinger-Ellison syndrome--changes in surgical therapy. Analysis of 27 patients].

In 10 out of 27 patients with a Zollinger-Ellison syndrome a gastrin-producing tumor was removed, in 5 localized with phlebography. In the remaining 12 patients the diagnosis of a gastrinoma was based on clinical data only. The 10 patients with surgically proven gastrinoma did not differ in their fasting blood-glucose levels, rise of gastrin serum levels after administration of secretin and calcium, in acid production patterns nor in survival time from those 12 patients in whom no gastric-producing tumor had been found. 5 of the 27 patients died, 4 just after surgery. One patient died from advanced malignant disease. In three of our patients localizing diagnostic procedures and consecutive tumor-removal were feasible with the protection of H2-receptor antagonists. The trend in the treatment of ZES goes away from elective total gastrectomy towards conservative treatment with H2-receptor antagonists in view of the low morbidity and the attempt of curative treatment by tumor-removal.

Adult↗
PubMed1981

[Splenectomy in Werlhof disease without thrombocyte substitution. Prospective study of 7 consecutive cases].

As a prophylaxis against the risk of postoperative bleeding platelet mass transfusions or transfusions of whole fresh blood are recommended for splenectomy in chronic idiopathic thrombocytopenic purpura. As the efficacy of this treatment is uncertain, seven consecutive patients with platelet counts of 4000/mm3 (2000-16000) were splenectomized without this prophylaxis. Platelet counts rose to 152500/mm3 (70000--305000) 18 h after operation, in every case the critical lower limit of 50000 was exceeded. Apart from one case of transient fever of undetected origin and one small pleural effusion there were no complications. Even in patients with extremely low platelet counts splenectomy can be performed without platelet mass transfusion.

Adolescent↗
PubMed1981

[The effect of normothermic and hypothermic gastric irrigation on blood flow of the canine stomach (author's transl)].

A gastric irrigation by an open naso-gastric tube with ice-solutions is a standard procedure in the management of upper gastrointestinal bleeding. In 6 dogs the effect of an increased intragastric pressure and of gastric cooling upon gastric blood flow was examined, using radioactive microspheres. Filling the stomach with saline solution of 38 degrees C to an intragastric pressure of 15 cm H2O reduces canine gastric blood flow from 21,3 +/- 4,4 ml X 100 g-1 X min-1 to 12,6 +/- 2,9 ml significantly. Probably as a consequence of compression only mucosal blood flow is lowered. Blood flow during local hypothermia (21 degrees C at the outer wall of the stomach) at the same intragastric pressure is 60% less than the control value at empty stomach and 33% less than the value at increased pressure without lowered temperature (p less than 0,01). Blood flow to the muscularis is now reduced too. This may be explained by vasoconstriction. However, local hypothermia causes the stomach wall bleeding time to increase three times (13), whereas irrigation by 38 degrees C fluid doesn't alter the coagulation of blood. An irrigation with high volumes of a fluid with body-temperature, which lowers gastric blood flow without changing coagulation and with an open system, which allows the cleaning of the stomach, seems to be more valuable than local hypothermia by a ballon system.

Animals↗
PubMed1980

[Cholelithiasis in a previously not described case of congenital erythropoietic porphyria (author's transl)].

The signs of congenital erythropoietic porphyria (Günther) had their onset at the age of two in a male patient born in 1934: there were blisters and scars after exposure to sunlight, red urine, marked cutaneous pigmentation, acral mutilation, lanugo and erythrodontia. Porphyrin levels in red blood cells and urine confirmed the diagnosis. Splenectomy was performed in 1966 for hypersplenism and haemolysis. No transfusion has been necessary since and the haemolysis has completely disappeared, but signs of ineffective erythropoiesis have continued. Cholecystectomy with choledochal revision was performed because of right upper abdominal colics, fever and biliary stasis in 1977: five partly pigmented, partly mixed gall-stones were removed. The latter had a black, friable centre with high porphyrin content and a cholesterol coating. Thus, as in other chronic haemolyses, pigmented gall-stones may also occur in congenital erythropoetic porphyria.

Adult↗
PubMed1979

[Open and closed chest trauma (author's transl)].

The observations made in 1,023 cases of chest trauma during 1947-1976 inclusive are analysed. According to the extent of the injuries they were classified as mild (group 1), moderate (group 2) and severe (group 3). The clinical picture was dominated by other than chest injuries in 45% of patients in group 1, in 66% in group 2 and in 51% in group 3. Injuries to the intrathoracic organs were seen in only 34 patients. Total mortality of all chest injuries was 12%; in group 3 it was 62%. Severe respiratory insufficiency was the direct cause of death in 25% of persons in group 3.

Bronchopneumonia↗
PubMed1979

[Traumatic rupture of the diaphragm (author's transl)].

Traumatic rupture of the diaphragm is diagnosed during the acute stage in only 50% of the cases. The reasons for this failure are that in many of these cases clinical symptoms of damage to abdominal organs or of injuries to the limbs predominate. Traumatic rupture of the diaphragm is usually the result of an indirect trauma. Clinical signs of extensive prolapse of viscera into the thoracic cavity are: dyspnoea, tachycardia, cyanosis or intestinal sounds heard over the thorax during auscultation. Once the diagnosis has been established surgical repair should follow. During the acute stage laparotomy is preferable; thoracotomy is indicated during the chronic stage. Post-operative symptoms are: dyspnoea during exercise, pain in the affected half of the chest and roentgeno-kymographically demonstrable restrictions of movement in the ruptured side of the diaphragm.

Cyanosis↗
PubMed1978

Inhibition of human colonic adenylate cyclase by RMI 12330 A.

RMI 12330 A, a compound of the lactamamide series, is a potent inhibitor of vasoactive intestinal polypeptide(VIP)- and prostaglandin (PG)-stimulated colonic secretion in the rat. This substance was tested on the adenylate cyclase system in human colonic mucosa. RMI 12330 A inhibited PGE2-, 16,16-dimethyl-PGE2- as well as VIP-sensitive adenylate cyclases in a dose-related manner. Half-maximal inhibition of hormone-stimulated enzyme activities occurred at a lactamimide concentration of about 0.15 mM. Lactamimide inhibition was non-competitive. Our results are compatible with the concept of RMI 12330 A acting as an inhibitor of colonic secretion via inhibition of hormone-sensitive adenylate cyclase. Since basal, NaF- and guanylyl-imidodiphosphate-stimulated enzyme activities were also affected by this compound, we may conclude that RMI 12330 A is a non-specific inhibitor of the human colonic adenylate cyclase system.

Adenylyl Cyclases↗
PubMed1978

[Local gastric fibrinolysis].

Local fibrinolytic activity was studied in normal and hemorrhagic gastric juice and in the gastric wall of men and pigs. This activity was definitely higher in hemorrhagic juice than in normal gastric juice, and its probably released from hemolyzed erythrocytes and mucosal lesions of the gastric wall.

Animals↗
PubMed1978

[The effect of vagus and sypathetic nerves on blood flow in the swine stomach].

Porcine gastric blood flow (radioactive microspheres) was studied (aortic blood pressure controlled) under five conditions: control (n = 8), electric stimulation of the splanchnic nerves (n = 8) and the vagus nerves (n = 8), truncal vagotomy (n = 8), and gastric sympathectomy (splanchnicotomy, n = 5). Highly significant increase in corpus mucosa flow after vagal stimulation or gastric sympathectomy is antagonistic to changes after splanchnic stimulation and truncal vagotomyand is often contrary to changes of the antrum mucosa. This might be an explanation fir ischemic gastric lesions (stress ulcer) after stress-induced high sympathetic tone (1, 2) and stress ulcer prophylaxis by gastric sympathectomy (3, 4).

Animals↗
PubMed1977

[Recurrent retroperitoneal giant lipoma (author's transl)].

A giant lipoma weighing 9.1 kg situated retroperitoneally which was removed by operation from a 74-year-old woman is reported. The diagnosis of tumors is discussed. The characteristics of this primary benign tumor such as the rapid growth, tendency to malignant degeneration and recurrence make radical surgical removal necessary.

Aged↗