[Blueprint for the specialty of special care].
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Biomedical subjects
Publications and source records attributed to A Elias.
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Thirty-four patients, most with a low-renin "essential" hypertension, and seven normal subjects were placed on diuretic therapy for 4 to 5 weeks. In the normal subjects, infusion of a highly specific, competitive angiotensin II analogue (1-sar-8-ala-angiotensin II, saralasin) did not significantly change recumbent blood pressure either before or after diuretic administration. In contrast, the hypertensive patients as a group had a low stimulated plasma renin activity before diuretic therapy and a rise in blood pressure during saralasin infusion. After therapy, the stimulated plasma renin activity was higher and saralasin produced a fall in blood pressure in some patients who were still hypertensive. The results suggest that short-term diuretic therapy, which is thought to act through its natriuretic effects, can convert some patients with essential hypertension, many with a low or a low-normal stimulated plasma renin activity, to individuals whose hypertension is supported by angiotensin II. The fall in blood pressure to saralsin infusion after diuretic therapy was directly proportional to the height to which diuretics elevated the stimulated plasma renin activity.
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A comparison of the seal provided by gutta-percha root canal filling, heat-sealed gutta-percha, retrograde amalgam filling, and retrograde Durelon filling was made by observation of dye penetration around the above filling materials in extracted teeth. A small but not significant difference between gutta-percha, heat-sealed gutta-percha, and retrograde amalgam was noted. Retrograde Durelon filling gave a poor seal in comparison to gutta-percha and retrograde amalgam filling, but the difference between it and the heat seal was not significant.
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