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Biomedical subjects

A Elbadawi

Publications and source records attributed to A Elbadawi.

At least 73 records · Page 4Linked to original sources
PubMed1977

Unfocused ultrasound for localized tissue destruction in rabbit kidneys.

The rabbit kidney was subjected to exposure from an unfocused ultrasound source in an effort to create a relatively large volume of ultrasound-damaged tissue in the rabbit kidney. The results of this exposure were followed for 1 year. An insignificant change in blood pressure was noted up to 1 month after exposure to ultrasound and no persistent hypertension was noted thereafter. Marked gross, histologic, and vascular changes were found in the area of exposure culminating in marked absorption of renal substance (in excess of 25 per cent of total kidney weight). Calcific stones formed in the pelvis of the kidney in virtually all animals observed from 6 months to 1 year after ultrasound exposure. These stones appeared to be related to the calcification within the transitional epithelium of tubules at the junction of normal and ultrasound-damaged tissue. The marked ability of the absorptive processes to ablate large volumes of physically damaged tissue is demonstrated.

Animals↗
PubMed1976

Hexachrome modification of Movat's stain.

A less than three-hour hexachrome modification of Movat's pentachrome stain is described, its various steps discussed, and its principal uses in histopathology presented. The hexachrome procedure consistently yields good results, with excellent and colorful differentiation of muscle, various connective tissue components, mucinous secretions and intra-cytoplasmic structures in human and animal tissues obtained surgically or at autopsy. Alternative abbreviated procedures for muscle-connective tissue differential staining and for study of nuclear detail are also described.

Animals↗
PubMed1976

Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases.

Two adult male patients with acute leukemia developed a fatal Budd-Chiari-like illness while receiving 6-thioguanine. Both had previously received cytosine arabinoside. Antemortem and postmortem specimens of liver showed changes characteristic of toxic veno-occlusive disease. Similar findings have been described after ingestion of certain plant alkaloids and after treatment with arsphenamine, urethane, and ionizing radiation to the liver. We are unaware of any published reports of veno-occlusive disease of the liver after treatment with either 6-thioguanine or cytosine arabinoside. Although 6-thioguanine was most likely responsible for this syndrome, it is not possible to eliminate cytosine arabinoside as the causative agent. Since both drugs are occasionally used for benign conditions, physicians should be aware of this possible complication.

Acute Disease↗
PubMed1976

Histomorphologic features of ultrasonic renal injury.

Fifteen-second exposure of rabbit kidneys to 2 MHz focused ultrasound with approximately 900 w/sq cm acoustic power consistently produced localized parenchymal destruction. Evolution of the lesions was followed histologically over a one-year period. The lesions were sharply delineated from outlying renal tissue and had a concentric multizonal structure. Resorption of the damaged tissue with scarring was completed in 6 to 12 months following intermediate phases characterized by cellular infiltration. The lesions are compared to other models of renal injury, particularly with respect to cellular infiltration. A combination of mechanical, thermal, and ischemic factors seem to be responsible for development of ultrasonic lesions. The sharply circumscribed nature and ultimate complete scarring of the lesions suggest the feasibility of ultrasound in achieving selective complete destruction of renal parenchyma.

Animals↗