54 adult male patients suffering from acute uncomplicated gonococcal urethritis entered a dose-range trial with a new parenteral cephalosporin, ceftriaxone Ro 13-9904. In order to evaluate the lowest effective dose of a single intramuscular injection of Ro 13-9904, the patients received different doses in descending order: 500 mg for the first group of 10 patients, 250 mg for the second group of 13 patients, 125 mg for the third group of 11 patients and 50 mg for the fourth group of 20 patients. All 34 patients of the first three trial groups were cured clinically and bacteriologically. In the group receiving 50 mg of the cephalosporin, 1 patient was bacteriologically a failure and a second was considered to be a reinfection. 7 further patients of this trial group showed clinical symptoms of urethritis after therapy, but gonococci were eradicated. The systemic and local tolerance of the drug was satisfactory. On the basis of this trial, the lowest effective dose for the eradication of Neisseria gonorrhoeae in male patients with uncomplicated gonorrhoea seems to be a single injection of between 50 and 125 mg of Ro 13-9904.

Adult↗

PubMed1977

[Therapy of acute gonorrhea].

Since the appearance of totally resistant, penicillinase producing gonococci, penicillin should no longer be considered first choice in the treatment of acute gonorrhea. In order to limit further extension of resistant strains, thiamphenicol (Urfamycin 2,5 p.o. or 0,75 i.m.) or spectinomycin (Trobicin 2,0 i.m.) are suggested as replacements for penicillin.

Acute Disease↗

PubMed1977

[A surgical treatment of hyperhidrosis axillaris (author's transl)].

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Axilla↗

PubMed1977

[Therapy of recurrent herpes simplex].

The topical and systemic possibilities of treatment of herpes simplex recidivans are discussed in a brief report. The antigen therapy with Lupidon is mentioned in detail. A selection of important clinical reports on Lupidon is commented. These reports demonstrate a good to very good therapeutic effect of Lupidon in relapsing herpes simplex with more than 1500 controlled patients. A statistically confirmed result of the long-term antigen therapy with Lupidon was particularly demonstrated in controlled double blank tests. Up to now there were not observed any severe side effects with this great number of patients.

Antibodies, Viral↗

PubMed1977

[Operative therapy of hyperhidrosis axillaris (author's transl)].

Development and problems connected with the surgical treatment of hyperhidrosis are considered. 32 patients were operated according to the method of Préaux. The results are good, both cosmetically and with regard to the diminution of the excessive sweat production.

Axilla↗