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Biomedical subjects

A E Wright

Publications and source records attributed to A E Wright.

At least 55 records · Page 3Linked to original sources
PubMed1981

Isolation of Murray Valley encephalitis virus and other arboviruses in the Ord River Valley 1972-1976.

This paper summarizes the isolation of arboviruses from mosquitoes collected in the Ord Valley between 1972 and 1976. A total of one hundred and ninety five strains of at least fifteen antigenically distinct viruses have been isolated. Seven of these isolates appear to be "new' antigenic types, and several are undergoing further testing. These are three new rhabdoviruses (Kununurra [OR194], a virus provisionally named Kimberley [OR250] and OR189 [provisionally named Parry's Creek]), three ungrouped, non-haemagglutinating viruses (OR379, OR512, OR869) and a virus (OR540) which reacts to Poly Anopheles A world grouping fluid. The remaining viruses have been previously identified in Australia. These include Murray Valley encephalitis (MVE), Kunjin, Kokobera, Sindbis, Koongol, Wongal, Wongorr and a virus in the Corriparta serological group. The most important finding of these studies is that MVE displays as annually recurrent pattern of activity with a peak seasonal transmission rate at the end of the wet monsoon. This is the first definition of a probable endemic focus of MVE activity in Australia. The major vector for the majority of the viruses isolated was, by inference, Culex annulirostris. However, Aedeomyia catasticta was implicated as a major vector of the Corriparta group virus.

Animals↗
PubMed1981

A preliminary investigation of the ecology of arboviruses in the Derby area of the Kimberley region, Western Australia.

A survey of mosquito populations in the Derby area of the Kimberley region, Western Australia, in March/April of 1977 yielded a total of 3,318 adult female mosquitoes. Fifteen taxa were represented, seven being new locality records for this area. Culex annulirostris was the dominant species, comprising 85.41% of the total catch. All mosquitoes collected were processed for virus isolation and thirteen strains of four (and possibly five) distinct arboviruses were obtained, all from pools of Culex annulirostris. These viruses include Murray Valley encephalitis, Ross River, Wongal, an untyped non-haemagglutinating member of the Koongol group and a virus which reacts to polyvalent antisera against the Anopheles A and B groups. With the exception of Ross River, all these viruses had been previously isolated from the Ord River Valley, some 500 km to the north-east. Comparison of virus isolations in the Ord Valley and Derby supports the suggestion that both sites share a common viral flora. Both also display an exceedingly high overall isolation rate (approximately 20% for Cx. annulirostris pools). Such comparisons suggest that a number of arboviruses transmitted by Cx. annulirostris are active throughout the Kimberley region and have peak isolation rates at the end of the wet season. Further studies are needed to fully define these viral cycles.

Animals↗
PubMed1978

Outbreak of infantile enteritis caused by enterotoxigenic Escherichia coli O6.H16.

Ten out of 18 babies at risk developed enteritis in an outbreak in a special-care baby unit. Salmonella, Shigella, and Escherichia coli belonging to the traditional infantile enteropathogenic serogroups were not found in faeces from the babies and the staff, and no virus particles were found by electron microscopy. Detailed serotyping of E. coli showed that five of the 10 babies with diarrhoea and one of the eight without diarrhoea were excreting E. coli O6.H16. All six isolates of this serotype produced both heat-labile and heat-stable enterotoxin. Enterotoxigenic strains of E. coli O6.H16 have caused outbreaks of enteritis in adults in the USA and Japan.

Disease Outbreaks↗
PubMed1978

Stereotactic implantation of iridium192 into CNS neoplasms.

A new method of stereotactic implantation of Iridium192 into CNS neoplasms is presented along with a method for tumor localization by computerized axial tomography, stereotactic angiography and stereotactic serial biopsies. A case treated with this technique is presented with an encouraging short term result.

Basal Ganglia Diseases↗
PubMed1978

Effect of pulmonary function of split-course radiation therapy for carcinoma of the lung.

A group of patients treated with radiation therapy for bronchogenic carcinoma were evaluated with serial pulmonary function testing. The patients were treated with a split-course technique with 60-Cobalt. A total of 30 patients with unresectable carcinoma have been studied. Measurements of vital capacity (V.C.) and forced expiratory volume at one second (F.E.V.1) were made prior to therapy; at the beginning and end of the split; upon completion of therapy; and thereafter at 1, 2, and 6 months post therapy. The percentage changes in V.C. and F.E.V.1 from pretreatment values are plotted against time. A trend to improve throughout the treatment course is suggested by these results. Twelve patients have been studied at six-month follow-up: eight of the patients showed less than a 10% reduction from pretreatment V.C. and F.E.V.1 and had no respiratory impairment; of the other four patients, three had evidence of progression of disease in the thorax.

Carcinoma, Bronchogenic↗
PubMed1961

Coccidiosis in guinea-pigs.

The attention of laboratory workers is drawn to the possibility of coccidiosis as a cause of death in guinea-pigs. The purchase of a number of guinea-pigs infected with this protozoon was followed by 12 deaths when these animals were injected with material for diagnostic purposes. No deaths occurred in the laboratory stock herd, as these were kept separate from the newcomers and were not infected. The life history of the parasite is described, together with the post-mortem findings in our series of animals.

Journal Article↗