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Biomedical subjects

A Duprez

Publications and source records attributed to A Duprez.

At least 73 records · Page 4Linked to original sources

[Macroscopic and microscopic study of human corpse skin grafting on athymic mice nu/nu].

32 thin grafts (500 to 700 mu) of different human corpse skin set apart during the first 24 hrs after the death have retaken on athymic Mousse whatever the reason of death and the age of the donor. 20 thick grafts have retaken at 30%. These skins preserve the aspects and behaviour of normal human skin but after 1 month they have a heavy melanic hyperpigmentation. These skins preserve their normal histological aspect during the first 3 days, then, when revascularisation is setting in, superficial areas of epidermic mortification, opposite dermal hypovascularised zones, appear. Between the 15th and the 21st day the epidermic alterations disappear and a heavy melanic hyperpigmentation is set up. The revascularisation is certainly the result of the human dermal vessels repermeabilisation. Till the 76th day neither dystrophy, dysplasia nor important inflammatory process exist.

Adult↗

[Complex pneumoconiosis in dental laboratory technicians].

Five cases of complex pneumoconiosis are described in dental prosthesis makers. The histo-spectrographic analysis with Castaing's microprobe of the lung fragment obtained by surgical biopsy revealed a complex disease associating silicosis of cobalt pneumoconiosis.

Adult↗

[A rare tumour of the right hypochondrium in the child (author's transl)].

Pancreatic pathology in the child is rare and usually limited to necrotic or traumatic pseudo-cysts. The authors report a case of multicystic dysplasis localised in the pancreas in a one-year old infant. The preoperative diagnosis of a traumatic cyst was made in error as the result of the discovery of a fracture of the skull. At operation, the "tumour" was seen to be a multicystic mass within the duodenal loop but pediculated under the inferior surface of the pancreas. Histological examination confirmed its dysplasic nature. The presence, as a result of vascular compression, together with the post-operative resolution of hypertension lend further originality to this case.

Diagnosis, Differential↗

[Chronic tubulo-interstitial nephropathy and tapetal-retinal degeneration. Senior's syndrome?].

Following Contreras and Espinoza in 1960, Senior and Loken, in 1961, described a new familial entity in which were associated renal and eye involvement in addition to Alport and Lowe's syndromes. About 30 cases of this syndrome have been reported until now. We report here a new case discovered with very advanced renal failure. No metabolic or enzymatic abnormality of the lysosomes was discovered. The family history and an investigation of the parents and six other siblings, did not reveal any similar case. Frequency of the morbid association, interstitial nephritis and retinal degeneration, is definitely underestimated. It raises numerous problems concerning the hereditary causes and the metabolic nature of both conditions, together with its place in classification of tubulo-interstitial nephritis described under the term of nephronophtisis. In practice, recognition of this association should permit early detection of the various components and assessment of the prognosis and family risk.

Adolescent↗

[Regional chemotherapy of stomach cancers].

Fifty patients with a stomach cancer received regional chemotherapy by infusion. Two kinds of cancers were treated with this technique: cancers inaccessible with usual surgical treatment and some limited cancers. In most cases, the catheter was introduced by transcutaneous puncture of axillary artery. According to the site of the cancer, the extremity of the catheter was introduced into the left gastric artery, hepatic artery or coeliac trunk. Efficiency of the infusion was checked by arteriography and by gastric fibroscopic examination with intra-arterial injection of evans blue. The duration of the treatment was two weeks or three weeks. The chemotherapy was made on a sequential method, taking account of the tumoral cellular cycle. The results show an objective response in 80 per cent of the cases, 39 per cent of the non operable cancers were later accessible to surgery. This study shows that chemotherapy should be used in the treatment of any stomach's cancers before surgical treatment.

Adult↗