Search PubMed⌕ Search

Biomedical subjects

A Donath

Publications and source records attributed to A Donath.

At least 91 records · Page 5Linked to original sources
PubMed1977

[Decrease of intestinal absorption of 47-calcium in chronic alcoholism].

Intestinal 47-calcium absorption has been studied in 34 chronic alcoholics, 17 of whom were cirrhotics (group A) and 17 non-cirrhotics (group B). These patients were compared with 44 normal subjects (group C). In group C, the 47Ca 2 h plasma % of the dose showed a significant negative correlation to the total body weight (p less than 0.001) and a positive correlation with the serum albumin (p less than 0.05). The mean intestinal absorption of 47Ca expressed as 2 h plasma % of the dose multiplied by total body weight was 131 +/- SD 52 in group A and 136 +/- SD 71 in group B. These two means are significantly low (p less than 0.001 and p less than 0.002 respectively) in relation to that found in group C (168 +/- SD 32). These results suggest that intestinal calcium absorption is diminished in chronic alcoholism even in the absence of hepatic cirrhosis.

Alcoholism↗
PubMed1977

[25-hydroxy vitamin D deficiency with reduction of intestinal calcium absorption and bone density in chronic alcoholism].

Plasma levels of 25-hydroxycalciferol (25-OH-D), 47-calcium intestinal absorption, bone mineral content and the biologic parameters of phospho-calcium metabolism were studied in 30 chronic alcoholics, 15 with Laennec's cirrhosis (group A) and 15 without (group B). These patients were compared with 27 normal subjects. In group A, the mean 25-OH-D plasma level was 23.7 +/- SD 18.5 microgram/l and in group B 35.2 +/- SD 21.8 microgram/l. These mean levels were lower than those of the control group, which were 57.2 +/- SD 22.5 microgram/l (p less than 0.001). The mean value of the 47Ca intestinal absorption, measured as the percentage of the ingested dose per litre of plasma and multiplied by the body weight, was also significantly lower in group A, which was 140 +/- SD 47 (p less than 0.01), and in group B, which was 145 +/- SD 69 (p less than 0.05), compared with the normal subjects whose average was 182 +/- SD 45.6. Similarly, the total plasma calcium was low: 1.99 +/- SD 0.24 mmol/l in all the alcoholics, while that of the control group was 2.22 +/- SD 0.18 mmol/l (p less than 0.001). For the 30 chronic alcoholics there was a positive correlation between 25-OH-D and 47Ca intestinal absorption, (r = 0.484; p less than 0.004). This suggests that in chronic alcoholism the deficiency of 25-OH-D induces a diminution of the intestinal absorption of calcium which, in the long term, can result in bone demineralization evidenced in the patients studied by a bone mineral content lower than normal (p less than 0.001).

Adult↗
PubMed1977

[Effect of alcohol on iron absorption].

The authors have investigated the assumption that alcohol increases iron absorption. Using the whole body counter technique, they show that iron absorption is lowered significantly by addition to the test dose of either normal or dealcoholized whisky, but that there is no difference between these two latter groups. Wine has a similar effect. The use of ethanol added to a test meal demonstrates that it is organic iron, and not the inorganic form, whose absorption is diminished by alcohol.

Ethanol↗
PubMed1976

[Industrial fluorosis].

43 potroom workers (aluminium industry) with fluorosis have been compared with 18 foundry workers of the same age, but who had never been exposed to fluorides. Clinical examination revealed a higher incidence of articular pain and limitation of motion in the exposed group. The diagnosis of fluorosis is not only clinical but calls for other investigations such as urinary fluoride determination, bone radiology and, above all, bone biopsy for fluoride determination, histology and microradiography.

Aged↗
PubMed1975

The effect of calcium infusions on renal handling of amino acids in hypophosphatemic vitamin D resistant rickets.

Amino acid clearances were studied in four patients with hypophosphatemic vitamin D resistant rickets. T,e clearances of the single amino acids in the patients did not differ from that of control individuals for all amino acids tested. The reabsorption of amino acids and phosphate was further investigated with the use of calcium infusions. Under these conditions there was a significant decrease in the filtered fraction of phosphate and amino acid excreted in the vitamin D resistant group suggesting a depression of parathyroid hormone secretion. It seems likely, as demonstrated in the vitamin D resistant group, that in this disorder the renal tubule is particularly sensitive to changes in parathyroid hormone secretion in respect to amino acid reabsorption.

Adolescent↗