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Biomedical subjects

A Dobozy

Publications and source records attributed to A Dobozy.

At least 145 records · Page 8Linked to original sources
PubMed1978

[Porphyria cutanea tarda--a multifactorial hereditary disease? A working hypothesis].

The influence of genetic and hepatotoxic factors in the development of porphyria cutanea tarda was studied in 51 patients with this disease. According to their data and findings in literature, the following hypothesis was made: porphyria cutanea tarda is assumed to be a disease following the rules of the polygenetical heredity. The appearance of the disease seems to be influenced by genetic rules, and hepatotoxic factors are playing a role in the manifestation of the disease.

Alcoholism↗
PubMed1977

Autoimmune anti-T cell antibodies in the sera of patients with mycosis fungoides.

The serum of persons with mycosis fungoides contains IgG antibody believed to be specific for T cells, similar to the auto-antibodies reported in patients with systemic lupus erythematosus, Hodgkin's disease and sarcoidosis. The antibody is present during the active, and disappears during the inactive, phase of the disease.

Adult↗
PubMed1977

Proportions of mouse erythrocyte rosette-forming lymphocytes, immunoglobulin-bearing cells and E rosettes in patients with lymphoproliferative diseases.

The proportions of mouse erythrocyte rosette-forming (MERF) lymphocytes, immunoglobulin (Ig)-bearing cells and E rosettes were examined in the peripheral blood of patients with lymphoproliferative diseases. The proportion of MERF lymphocytes was considerably increased in chronic lymphocytic leukaemia. The correlation between the proportions of MERF and Ig-bearing cells, characteristic of healthy individuals, is not observed in the lymphoproliferative diseases. It is suggested that in a part of the patients with these diseases, the study of the proportion of MERF cells provides more accurate information on the proportion of lymphocytes of bursal origin than does counting of the Ig-bearing cells.

Erythrocytes↗
PubMed1977

B and T cell markers of bone marrow and peripheral blood lymphoid cells in patients with paraproteinaemia.

Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.

Animals↗
PubMed1977

[In-vitro-investigation of immuno lymphocytolysis by influence of streptolysin O (author's transl)].

The cytolytic effect of Streptolysin O to leucocytes, T and B lymphocytes and granulocytes has been examined using an in vitro immuno lymphocytolytic test at 62 patients with different dermatological diseases. This test was established to be only about the immuno-cytolytic reaction of the T lymphocytes, and this process was bound to the present of complement. It is suggested that this method is suitable to in vitro study of the cellular immunity of patients with chronic infectious diseases.

Adult↗
PubMed1976

[Investigations of the T and B cells and the hemopexin-carrying lymphocytes in cases of porphyria cutanea tarda (author's transl)].

The immunoglobulins and hemopexin carrying cells have been determined in 14 patients having Porphyria cutanea tarda and in 15 healthy volunteers. At the same time, the stimulating effect of phytohemaglutinine and the leucocytesmigration inhibition by purified tuberculine proteins, were measured. In the 14 cases of Porphyria cutanea tarda, the IgG content and the number of hemopexin carrying lymphocytes was significantly increased, while the amounts of the other immunoglobuline carrying cells, and of T lymphocytes, was unchanged. Phytohemaglutinine stimulation and inhibition of leukocytes migration by purified tuberculine proteins were found to be identical in both patients and control groups.

Aged↗
PubMed1976

Effect of hydrocortisone 17-butyrate on the percutaneous absorption of antibiotics.

Abrption of antibiotics from combined preparations containing oxytetracycline, chlortetracycline, doxycycline or gentamicin and hydrocortisone 17-butyrate into the skin of rats was examined. The penetration of antibiotics from the ointment into the skin was inhibited by 0.2% hydrocortisone 17-butyrate to a significant degree. It is suggested that this effect of hydrocortisone 17-butyrate is the consequence of its vasoconstrictor action.

Administration, Topical↗