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Biomedical subjects

A Dimitrov

Publications and source records attributed to A Dimitrov.

At least 127 records · Page 7Linked to original sources
PubMed1985

[Histogenesis of leukemic changes in cows].

A histopathologic study was carried out on lymph nodes and viscera of 98 cows and 28 heifers that responded positively in serologic examinations for leukosis. The animals did not exhibit clinical and paraclinical symptoms, neither were there found any morphologic changes characteristic of leukosis. There existed activation and proliferation of the reticuloendothelial tissue in the sinuses of the lymph nodes. The same response was shown by the endothelium of the capillaries in visceral organs. There was also metaplasia that concerned mainly the connective tissue cells of the lymph node trabeculas as well as the adventitial cells of the vascular walls. It was considered that the infection could be manifested morphologically as a reticuloendotheliosis. By its clinical course and morphologic manifestation bovine leukosis resembles some other virus diseases that have been systematized as "delayed virus infections'.

Animals↗
PubMed1985

[Histochemical changes in leukemia in cattle].

Histochemical investigations were carried out to demonstrate the activity of succinic dehydrogenase, diphosphopyridine-nucleotid-diaphorase, alkaline phosphatase, and acid phosphatase in the liver, kidneys, lymph nodes, and heart muscle of a total of 20 cows with positive serologic response for leukosis as well as in organs of 2 normal controls. It was found that the lymphoid cells of the leukotic proliferations and the activated endothelial and adventitial cells of the blood vessels had high alkaline phosphatase activity and negligibly expressed acid phosphatase activity. Dehydrogenase activity was low in the lymphoid-cell proliferations and in the activated cell of the vessels. The cell metabolism of the leukotic proliferations was like-wise disturbed. Histochemical methods of investigations could be used test-like in the diagnosis of bovine leukosis.

Animals↗
PubMed1982

[Bacteriological and morphological findings in aborted cattle fetuses].

Bacteriologic investigations were carried out on a total of 142 fetuses aborted by cows. C. pyogenes, V. fetus, Streptococcus pyogenes animalis (Sofia), M. bovigenitalium, A. laidlawii, E. coli, and B. subtilis were isolated from 34 fetuses (24 per cent). Besides, single of these species were found in 80 per cent of the positive cases, and a mixed infection--in 20 per cent. The morphologic changes in all 34 fetuses that were positive were seen chiefly in the lungs and liver. Such lesions, however, were not instrumental in differentiating the etiologic agent.

Abortion, Veterinary↗
PubMed1981

[Anti-inflammatory action of a group of plant extracts].

Use was made of Wistar albino rats in which an inflammation was induced via the simultaneous injection of caraginan and prostaglandin E1 in order to evaluate the antiinflammatory activity of 6 freeze dried plant extracts. It was found that with such model of inflammation the inflammatory effect of caraginan was strongly enhanced, which was accompanied by the rapid and prolific white blood cell extravasates. The freeze-dried extracts of St. John's-wort (Hypericum perforatum L.), potmarigold calendula (Calendula officinalis L.), camomile (Matricaria chamomilla L.) and plantain (Plantago lanceolata L. et Pl. major L.) were found to suppress both the inflammatory effect and the leukocyte infiltration. The extracts of symphytum (Symphytum officinale L.) and those of flax seed (Linum usitatissimum L.) did not inhibit the inflammation, however, they suppressed the leukocyte infiltration at the 3rd and 4th hour of the induced inflammation.

Alprostadil↗
PubMed1980

[Pathomorphological changes in Brucella ovis-infected sheep].

In spontaneously infected with Br. ovis rams, as well as in experimentally infected with the same infection sheep and rams, besides the morphological changes in the epididymis with some part of the animals, we also observed granulomas in the lungs with a specific morphological structure. The presence of Br. ovis was proved in a number of organs such as the epididymis, the seminal ampullae, the lungs, the kidneys, the liver and the myocardium. In spite of the presence of bacteria no morphological changes were observed in the kidneys, the liver and the myocardium. The find of bacteria in the lungs was more frequent rather than the presence of granulomas.

Animals↗