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Biomedical subjects

A Denis

Publications and source records attributed to A Denis.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Calcifications after intra-disk injection of triamcinolone hexacetonide in lumbar disk hernia. Evaluation of therapeutical results in 3 years].

The development of disk or epidural calcifications is a frequent possibility following intra-disk injection of triamcinolone hexacetonide. It was found 10 times in 26 follow-up CT scans obtained 2 to 3 years after the injection. These calcifications are often clinically silent, but they sometimes accompany a recurrence of the initial painful symptomatology. Furthermore, evaluation at 3 years of therapeutic results in a previously published series of patients who had received an intra-disk injection of triamcinolone hexacetonide showed a marked decrease in favourable results (30% vs 67% at 6 months). These two arguments: disappointing long term results and possibility of disk calcifications, are felt by the authors to justify abandoning the technique of triamcinolone hexacetonide by intra-disk injection in the treatment of lumbar disk prolapse.

Adult↗
PubMed1990

[Prognostic factors in delivery with breech presentation. Apropos of 357 single-fetus pregnancies at term].

For a better definition of the factors which could be at the origin of neonatal distress, 357 cases of mono-fetal term pregnancies with breech presentation were retrospectively studied between January 1st, 1984 and December 31st, 1989. The population is identical to that of all deliveries except for a higher percentage of first pregnancies. The risk of emergency caesarean section mostly concerns large primiparous women, underweight, with normal or large pelvis. Caesarean section is absolutely necessary if the biparietal diameter exceeds 100 mm, if the head is positioned in hyper-deflection and/or if the pelvis is defective. Without being mandatory, the procedure is preferable in case of chronic fetal distress or scarred uterus. On the contrary, neither the age of the mother nor the age of the pregnancy, nor the type of the breech, nor the number of pregnancies have any effect on the prognosis. The current rate of caesarean section is 47.9 per cent with almost complete disappearance of the large breech extraction (0.6 per cent) and the Mauriceau's maneuver (0.3 per cent). The corrected mortality rate is 0.28 per cent. In addition to the parameters considered in our coefficient of risk of breech delivery, it was noted that a pre-pregnancy weight exceeding 70 kg or a weight gain of more than 15 kg represent unfavorable factors. It is desirable to calculate prospectively the severity of the risk in small size cases, when the biparietal diameter ranges between 96 and 100 mm, or when one of the diameters of the bony pelvis is decreased.

Adolescent↗
PubMed1987

[Acute hydrocephalus drained in emergency. Consequence of cerebellar infarction in Haemophilus meningitis].

A 2 year-old child admitted for Haemophilus meningitis was immediately treated by adequate antibiotic treatment. Three days later multiple hypertonic strokes and periodic respiration occurred; a resuscitation was necessary. CAT scan showed an acute hydrocephalus with non visible 4th ventricle and low-density areas in both cerebellar hemispheres allowing the diagnosis of cerebellar infarction. External drainage of CSF was rapidly performed and maintained for 11 days with success. The child was secondarily discharged with temporary cortical blindness and persistent moderate static cerebellar signs. The etiology of the cerebellar infarction was likely to be an arterial thrombosis in the vertebro-basilar area, probably secondary to cerebral arteritis related to Haemophilus.

Acute Disease↗
PubMed1986

Comparison of two new tests for rapid diagnosis of respiratory syncytial virus infections by enzyme-linked immunosorbent assay and immunofluorescence techniques.

The sensitivity and the specificity of two new commercial reagent tests, an indirect fluorescent antibody test (FAT) with a mouse monoclonal antibody (MAb) against respiratory syncytial virus (RSV) and an enzyme-linked immunosorbent assay (ELISA) RSV antigen detection kit, were determined by a comparison of results from these tests with those of tissue culture isolation and an indirect FAT with bovine polyclonal antibody (BPA). Of 251 nasal aspirates from infants with suspected RSV infection, positive results were found for 99 (39%) by the FAT-MAb, 93 (37%) by the FAT-BPA, and 87 (35%) by the ELISA; 69 of 240 (29%) were positive by cultures. The FAT-MAb was a more sensitive technique than cultures, with 87% sensitivity for the FAT-MAb and 84% for the ELISA. It was also more sensitive than the FAT-BPA, with 97% sensitivity for the FAT-MAb and 85% for the ELISA. This could be caused only by the distinctive volume of suspended specimens used in these tests. Of 171 negative culture specimens, positive (but not false-positive) results were found for 18% by the FAT-MAb and for 12% by the ELISA. Inversely, 13% of 69 culture positive specimens were FAT-MAb negative and 16% were ELISA negative, emphasizing the importance of tissue cultures for the maximum recovery of RSV, as well as for detection of other respiratory viruses. The FAT-MAb and ELISA were easy to perform and interpret, thus facilitating wider use.

Antigens, Viral↗
PubMed1986

[Rhinovirus and acute respiratory infections in infants].

Human leucocytary interferon (IFN) in a concentration of 2,000 Ul/ml stops the development of 9 Rhinovirus (RV) strains. The use of serum IFN antibodies (SAIF) reverses this effect. Of 256 nasal aspirates culture negative for other respiratory viruses, 40 RV were isolated with SAIF as opposed to 19 without serum anti IFN. The frequency and some clinical aspects are emphasized in infants: 43% had bronchiolitis similar to respiratory syncytial virus (RSV) infections and atopy was frequent.

Acute Disease↗
PubMed1984

[Neonatal ovarian cysts. Apropos of 4 cases].

When the authors had seen four cases of ovarian cysts in the newborn during the course of a few months they decided to describe this pathology. All four cases were discovered in utero during the course of ultrasound examination at gestationaL ages between 28 and 36 weeks. Pictures were obtained of round abdominal liquid areas measuring between 45 and 75 mm in diameter, which were separate from the bladder and the kidneys in female fetuses. One of the cysts showed two different ultrasound zones, of which one seemed to be a deposit of blood which was taken to be evidence of torsion of the ovary in utero. The diagnosis was confirmed after birth by clinical examination, straight X-ray of the abdomen, intravenous urography and ultrasound examination of the newborn. The pathological cause of these cysts is still unknown, but suggests that there was probably an abnormal stimulation by the mother's H.C.G. or abnormal enzyme activity of the theca interna. In each case delivery was vaginal. Although in each of these cases the cysts were benign they were treated surgically because all authors agree that there are risks of complications due to torsion or rupture and because one cannot be certain that they are benign.

Female↗
PubMed1984

[Cesarean section preceding the 34th week of amenorrhea: maternal and fetal repercussions at the western university hospitals. Regional survey or 383 cesarean sections and 436 newborn infants out of 86,116 births in 5 years].

This statistical enquiry carried out in a region of France by the University Hospital Services in Obstetrics and voluntarily devoid of bibliographical references, deals with a group that are particularly pathological and thus probably explains the seriousness of the prognosis for the newborn and the frequency of maternal morbidity following these early operations. 15% of serious maternal complications with severe neonatal pathology which was often heavy and responsible for the death of the fetus in 22.4% of the cases and the late sequelae in the newborn in more than 10% of cases, mad it important to seek for the inevitable link between the pathology and the length of gestation at the time of the operation. Only one in three children were alive without any sequelae after Caesarean carried out between 28 and 31 weeks, but more than 80% were alive when the operation was performed at 34 weeks. In view of these findings the authors suggest that each case should be considered very carefully before early Caesarean section is carried out, both from the advantages and disadvantages of this means of delivery for the baby as well as for the mother. Caesarean section before 30 weeks of amenorrhoea on an infant with an estimated weight of less than 1 000 grams is seldom to be recommended in view of the poor results for the newborn and in the absence of severe maternal pathology which requires immediate evacuation of the uterus. In view of the poor statistical results that have been analysed, early Caesarean section for fetal pathology and particularly for fetal distress when there is no adequate sophisticated means of resuscitating the baby should be lowered to the minimum possible figure. The comparative study of the notes shows that pathological conditions apparently similar to one another lead to occasions for carrying out very early Caesarean section, and also show that the outlook is different from the point of view of the immediate prognosis and a late prognosis for the newborn infant in view of the delay that has occurred before extracting the baby and of the facilities available to resuscitate the baby.

Academic Medical Centers↗
PubMed1982

The use of flupenthixol ('Fluanxol') in the management of behavioural disorders in disturbed and psychotic children.

Twenty-four children treated wih flupenthixol for behavioural disorders were studied in the out-patient clinic. The drug was given in small doses (0.4 to 2.0 mg per day) for periods ranging from 6 months to 2 years as an alternative to psychotherapy in cases where the latter was not possible. All patients were diagnosed clinically and psychologically as suffering from progressive symptoms of aggression or psychosis. Both the clinical and the psychological assessments showed improvement, particularly in insomnia and aggression. There was also improvement in social contact and concentration leading to improvement in performance at school. Although the health of the children remained very delicate, the results achieved with flupenthixol appeared to be stable even after treatment was stopped.

Adolescent↗
PubMed1982

[The oncomiricidium of Diplozoon nipponicum Goto, 1891. A new type of larval haptor for the genus Diplozoon (Monogenea, Discocotylidae)].

Diplozoon nipponicum Goto 1891, a branchial parasite of Cyprinus carpio is mentioned for the first time in France and Western Europe. Carps, along with their Monogenea, were introduced from Hungary. After being obtained experimentally, the oncomiracidium is thoroughly studied (excretory system, ciliated cells, chaetotaxy, haptor). A new haptor for the genus Diplozoon is described: two pairs of larval lateral hooklets are present. The taxonomic and phylogenic implications of these observations are discussed for Diplozoon and Discocotylidae. Mainly as a result of the study of the haptor and the egg structure, it appears that two groups occur, the taxonomic and evolutive significance of which are to be discussed in Diplozoon.

Animals↗