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Biomedical subjects

A D Steinfeld

Publications and source records attributed to A D Steinfeld.

At least 37 records · Page 2Linked to original sources
PubMed1990

Epidemic and classic Kaposi's sarcoma of the feet. A comparative study.

The clinical behavior of Kaposi's sarcoma involving the feet is compared for patients with and without AIDS. Although AIDS-related Kaposi's sarcoma is less likely to be confined to the legs than is non-AIDS-related Kaposi's sarcoma, the legs are the most common site of disease in both forms. Kaposi's sarcoma occurring in the AIDS setting is as radiosensitive as that which occurs in the patient without AIDS. Palliative radiotherapy can offer substantial relief for affected patients.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Patient age as a factor in radiotherapy. Data from the patterns of care study.

We studied the effect of patient age on treatment decisions related to radiation therapy using data obtained through the Patterns of Care Study. Definitive treatment given for breast cancer (191 patients) and palliative therapy given for a variety of symptoms (784 patients) were investigated using data collected from 49 facilities selected on a random basis to reflect fairly the national practice of radiotherapy. Elderly (aged 70 or older) patients accounted for 28.6% of the palliatively treated patients and 19.5% of the definitively treated breast patients. No correlation was found between patient age and the dose or number of days used in palliative therapy. Older patients were more likely to have the "boost" dose of radiation to the tumor bed delivered through external rather than implant techniques. While statistically significant, this difference is not felt to be clinically important. We conclude that once a patient is selected for a course of radiation therapy, age per se, is not a basis for prejudicial treatment.

Adult↗
PubMed1989

The prognostic significance of residual pigmentation following radiotherapy of epidemic Kaposi's sarcoma.

The response to radiotherapy of epidemic Kaposi's sarcoma (EKS) is unusual in that irradiated regions are frequently left with a persistent purple stain, reminiscent of the color of the original tumor, but with no tumor mass. To date there are no published data to indicate whether the persistence of pigmentation can be predicted beforehand or if it has any prognostic import. We reviewed the response to treatment of 118 EKS lesions that were irradiated at New York University (NYU) Medical Center between 1981 and 1986. A total of 86 responded to treatment by complete clearance of the mass. Of these, 29 left residual purple pigmentation within the treatment portal, while 57 did not. Complete response (CR; without residual pigmentation) occurred more often in patients who had higher Karnofsky scores at the time of treatment. However, in terms of ultimate local control or survival, there were no differences between patients whose lesions cleared completely v those in whom pigmentation remained. We conclude that persistent pigmentation represents only a benign remnant of irradiated EKS and has no prognostic import.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Psychological preparation of the patient and family.

Psychological preparation is crucial, for it will contribute importantly to the patient's and family's ability to adapt to a diagnosis of urologic cancer and to manage the stresses of treatment. Psychological preparation is an intrinsic component of early doctor-patient interactions, whether or not the physician and patient perceive it as such. Guidelines for the pivotal discussion concerning diagnosis and treatment plan are provided. The results of a survey of psychosocial adaptation among 39 patients treated for seminomatous testicular cancer and 39 controls are presented. Patients were found to exhibit typical or average emotional status. They were significantly more satisfied than controls with spouse/partner relationships. Despite important sexual and reproductive limitations reported by others, patients treated for testicular cancer adapt well, and most attain average or better degrees of satisfaction with interpersonal and sexual relationships. Newly diagnosed patients, beginning their adjustment to what often appears to be an overwhelming set of problems and potential limitations, should benefit from the knowledge that psychosocial adaptation is an eventual reality. Physicians' management of early discussions, as well as their openness to ongoing communication, contribute importantly to the perspective that will guide patients and families through this process.

Adult↗
PubMed1987

Brain metastases from carcinoma of bladder.

Two cases of bladder carcinoma metastatic to the brain are presented. In both instances the lesions were solitary, occurred following treatment of high-stage primary tumors, and were associated with short survival. The course of these 2 patients, as well as similar cases found in the literature, suggests that palliative therapy should be given in as brief a time span as possible.

Aged↗
PubMed1985

Relative role of abdominal pelvic CT and lymphangiography in staging of testicular seminoma.

Sixty patients with testicular seminoma were reviewed regarding the evaluation of the retroperitoneal lymph nodes. Thirty-four of these patients had both abdominal pelvic computerized tomography (APCT) scan and bipedal lymphangiography (LAG). In 21 patients, the results of the two studies were in agreement. However, 11 patients had positive LAG and negative APCT, while only 2 had a positive APCT and negative LAG. We recommend that patients with testicular seminoma have an APCT. If findings are negative, LAG should be done.

Dysgerminoma↗
PubMed1984

Postoperative adjuvant mediastinal radiation in lung cancer.

Postoperative adjuvant mediastinal radiation therapy was used in a group of 18 patients with advanced (nine Stage 2, nine Stage 3) non-small cell carcinoma of the lung who had undergone curative resection. All patients had metastases to hilar and/or mediastinal nodes. The disease-free survival at 2 1/2 years was 55% for Stage 2 patients, suggesting a survival advantage compared to historical controls. No benefit was found in Stage 3 patients. A prospective randomized study of adjuvant radiation in node-positive patients is indicated.

Adenocarcinoma↗
PubMed1984

Hodgkin's disease presenting in epitrochlear nodes.

Two cases of Hodgkin's Disease (HD) presenting in epitrochlear nodes are described, and compared to four similar cases gleaned from the literature. The nodular sclerosis type of HD was present in 5 of the 6 patients. Of the four patients staged with laparotomy, two had infradiaphragmatic disease. A treatment approach using radiation alone for patients with disease limited to the epitroclear region is presented, and anatomical considerations of the treatment technique are given.

Adult↗
PubMed1984

Seminoma of testicle metastatic to thyroid.

A twenty-four-year-old white man is described who presented with seminoma and initially was treated with standard inguinal orchiectomy and radiation therapy for retroperitoneal disease. The case is reported because of the unusual nature of his later recurrence of disease, which was in the right lobe of the thyroid gland. This is a rare site for isolated recurrence, and there is a paucity of reports of metastatic tumor of any type to the thyroid gland. The patient had a complete remission after combined chemotherapy with cyclophosphamide, vinblastine, bleomycin, and cisplatin.

Adult↗
PubMed1984

Recurrent and metastatic mesoblastic nephroma in infancy.

Local recurrence or metastasis of mesoblastic nephroma is extremely uncommon. The first report of a child with mesoblastic nephroma to have both of these problems is presented. The usual course of mesoblastic nephroma is benign, with nephrectomy being curative. Adjuvant treatment is not necessary and may be lethal. However, a review of the five patients who developed locally recurrent and/or metastatic tumor indicates that chemotherapy and radiotherapy are of benefit and can produce long-term disease-free survival.

Antineoplastic Agents↗
PubMed1980

Osteonecrosis in patients with Hodgkin disease following combination chemotherapy.

Three cases of osteonecrosis in patients receiving prednisone as part of multi-drug chemotherapy for lymphoma are presented. These patients are discussed in the context of previously reported series. The etiology of steroid-induced osteonecrosis and its radiologic manifestations are reviewed with regard to the need for biopsy to confirm the diagnosis. In light of this complication, the need for prednisone in lymphoma chemotherapy is considered.

Adult↗
PubMed1980

Radiation oncology.

Radiation may be used for the treatment of neoplastic lesions, either as a palliative measure or in an attempt at cure. Particulate or electromagnetic radiation can be obtained from a variety of machines and isotopes. Radiation therapy is the treatment of choice for certain malignancies and may be an acceptable alternative to surgery in others. Pre- or postoperative radiation is increasingly used to improve local control and survival. As with any therapeutic tool, acute and chronic complications may occur.

Female↗
PubMed1980

An ancient report of a dermoid cyst of the vagina.

There is a degree of imprecision in translating the Talmud from its original language into English. It is unlikely that we will ever know with certainty what a wart meant to the ancients. That this Talmudic reference represents the first description of a vaginal dermoid is a distinct possibility.

Bible↗