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Biomedical subjects

A D Jorge

Publications and source records attributed to A D Jorge.

28 records · Page 2Linked to original sources
PubMed1977

[Early detection of colonic and rectal cancer; extensive study of occult blood].

Due to the high frequency and usually late diagnosis of cancer of colon and rectum the "haemoccult test" has been recommended as an easy, quick, and unexpensive method for stool determination of occult blood that will allow us to suspect the existence of these tumors in their early asymptomatic stages. The test was performed in 1437 patients attending the gastroenterology clinic which had no clinical evidence of bleeding, of these, 1150 returned the samples. In 52 (4,6%) the test was positive for occult blood. The studies performed revelated that 4 were upper gastrointestinal ilions, one ileal diverticulum and 40 (3,47%) patients had colonic disease of the latter 19 were diverticular disease, 1 crohnis disease of rectum, 2 adenomatous and 2 villous polips, 1 Hodkgin disease and 7 carcinomas. There were 6 false positive results. The high frequency of positive "haemoccult test" in colonic disease, specially benign and malignant tumors, make this test and appropiate method of this time in the detection for colo-rectal carcinoma.

Adenocarcinoma↗
PubMed1977

[Ultrastructural study of chronic gastritis].

A study of gastric biopsies with optical and electronical microscope from patients with gastritis in different stages of evolution was realized. The ultraestructural results consist in phenomenal alterations at the epitelium level, apparition of bodies of mielinic aspects in the inside of the Oxintcs cells, reduction of the number of this and the peptic cells and even the disappearance of the last. There is an increase of the mucous cells with mitotic changes, notable hyperplasia of the arget cells and intestinal metaplasia in the advanced cases. In the stroma is demonstrative the infiltration of plasmatic cells having a endoplasmatic reticule in different stages of activity, linphocytes and macrophagous full of primary and secondary lysosomas. A very important fact is the increase of the argentofilous cells and its probably relation with the appearing of the gastritis. The presence of the plasma cells and lynphocyts mark the role that takes the immunitary reaction in this process.

Biopsy↗
PubMed1976

Double pylorus and esophageal achalasia.

29 cases of double pylorus have been reported so far. It is thought that in 85% of the cases it has been due to a fistulous gastro-duodenal ulcer and the remaining 15% would be of a congenital origin. In the case we have reported the double pylorus is believed to be a congenital anomaly associated with a mega-esophagus of similar etiology.

Aged↗
PubMed1976

Serum levels of C3 and cholinesterase in various diseases of the liver.

The levels of C3, cholinesterase, albumin and prothrombin were determined in 46 patients (27 males and 19 females) - 26 with cirrhosis of the liver, 9 with acute hepatitis, 6 with chronic aggressive hepatitis, 1 with chronic persistent hepatitis and 4 with fatty liver. In all patients and, particularly in those with cirrhotic liver, it was shown that the normal or pathological level of serum C 3 is related both qualitatively and quantitatively to the normal or pathological levels of cholinesterase, albumin, and prothrombin. The percentage in which the levels of these four parameters were pathological was considerably higher in the cases with hepatic coma than in the cases without hepatic coma. The determination of the range of confidence for the 4 parameters showed that, in the patients with hepatic coma, cholinesterase reacted most sensitively to liver damage (0.5 - 0.94) followed by C3 and prothrombin (0.33 - 0.81). Also in the cases without hepatic coma, cholinesterase was the most sensitive indicator (0.05 - 0.29), followed by prothrombin (0.03 - 0.24), albumin and C3 (0.00-0.16).

Cholinesterases↗
PubMed1973

The effect of azathioprine on gastric mucosal histology and acid secretion in chronic gastritis.

Fourteen patients were selected with advanced superficial chronic gastritis (grade II), marked chronic gastritis with partial atrophy (grade III), or chronic gastritis with total atrophy in which intestinal metaplasia was observed (grade IV). Azathioprine was administrated to all of them for periods varying from two and a half to six months. There were no side effects except in one patient, in whom nausea and vomiting made it necessary to remove him from the trial. Acid output in these 14 patients showed an average change which was statistically significant.Statistical analysis of the sample as a whole shows that, with a 0.95 probability improvement could be expected in 37 to 85% of the patients given azathioprine.

Adult↗